Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6Q3C

CDK2 in complex with FragLite1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000082	biological_process	G1/S transition of mitotic cell cycle
A	0000086	biological_process	G2/M transition of mitotic cell cycle
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
A	0000781	cellular_component	chromosome, telomeric region
A	0000793	cellular_component	condensed chromosome
A	0000805	cellular_component	X chromosome
A	0000806	cellular_component	Y chromosome
A	0001673	cellular_component	male germ cell nucleus
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005654	cellular_component	nucleoplasm
A	0005667	cellular_component	transcription regulator complex
A	0005737	cellular_component	cytoplasm
A	0005768	cellular_component	endosome
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0006338	biological_process	chromatin remodeling
A	0006351	biological_process	DNA-templated transcription
A	0006468	biological_process	protein phosphorylation
A	0006813	biological_process	potassium ion transport
A	0006974	biological_process	DNA damage response
A	0007099	biological_process	centriole replication
A	0007165	biological_process	signal transduction
A	0007265	biological_process	Ras protein signal transduction
A	0007346	biological_process	regulation of mitotic cell cycle
A	0008284	biological_process	positive regulation of cell population proliferation
A	0010389	biological_process	regulation of G2/M transition of mitotic cell cycle
A	0010468	biological_process	regulation of gene expression
A	0015030	cellular_component	Cajal body
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0018105	biological_process	peptidyl-serine phosphorylation
A	0019904	molecular_function	protein domain specific binding
A	0030332	molecular_function	cyclin binding
A	0031453	biological_process	positive regulation of heterochromatin formation
A	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
A	0032298	biological_process	positive regulation of DNA-templated DNA replication initiation
A	0035173	molecular_function	histone kinase activity
A	0043247	biological_process	telomere maintenance in response to DNA damage
A	0043687	biological_process	post-translational protein modification
A	0045740	biological_process	positive regulation of DNA replication
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0046872	molecular_function	metal ion binding
A	0051298	biological_process	centrosome duplication
A	0051301	biological_process	cell division
A	0051321	biological_process	meiotic cell cycle
A	0071732	biological_process	cellular response to nitric oxide
A	0090398	biological_process	cellular senescence
A	0097123	cellular_component	cyclin A1-CDK2 complex
A	0097124	cellular_component	cyclin A2-CDK2 complex
A	0097134	cellular_component	cyclin E1-CDK2 complex
A	0097135	cellular_component	cyclin E2-CDK2 complex
A	0097472	molecular_function	cyclin-dependent protein kinase activity
A	0106310	molecular_function	protein serine kinase activity
A	0120186	biological_process	negative regulation of protein localization to chromatin
A	0120261	biological_process	regulation of heterochromatin organization
A	1905784	biological_process	regulation of anaphase-promoting complex-dependent catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue BYZ A 301

Chain	Residue
A	ALA31
A	GLU81
A	PHE82
A	LEU83
A	LEU134
A	BYZ302

site_id	AC2
Number of Residues	8
Details	binding site for residue BYZ A 302

Chain	Residue
A	PHE82
A	LEU83
A	LEU134
A	BYZ301
A	HOH521
A	ALA31
A	LYS33
A	GLU81

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGTYGVVYkArnkltgev..........VALK

Chain	Residue	Details
A	ILE10-LYS33

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpqNLLI

Chain	Residue	Details
A	VAL123-ILE135

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17095507","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21565702","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21565702","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	3
Details	Site: {"description":"CDK7 binding","evidences":[{"source":"PubMed","id":"17373709","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"1396589","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17095507","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by WEE1","evidences":[{"source":"PubMed","id":"1396589","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17095507","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by CAK and CCRK","evidences":[{"source":"PubMed","id":"1396589","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14597612","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16325401","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17095507","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17570665","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20147522","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360007","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21565702","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28666995","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)