6Q1S

A hypothetical aminotransferase from Mycobacterium tuberculosis, alpha-ketoglutarate and PMP bound form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0008360	biological_process	regulation of cell shape
A	0008483	molecular_function	transaminase activity
A	0008696	molecular_function	4-amino-4-deoxychorismate lyase activity
A	0009252	biological_process	peptidoglycan biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016829	molecular_function	lyase activity
A	0019752	biological_process	carboxylic acid metabolic process
A	0030170	molecular_function	pyridoxal phosphate binding
A	0046394	biological_process	carboxylic acid biosynthetic process
A	0046654	biological_process	tetrahydrofolate biosynthetic process
A	0046656	biological_process	folic acid biosynthetic process
A	0047810	molecular_function	D-alanine-2-oxoglutarate aminotransferase activity
B	0003824	molecular_function	catalytic activity
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0008360	biological_process	regulation of cell shape
B	0008483	molecular_function	transaminase activity
B	0008696	molecular_function	4-amino-4-deoxychorismate lyase activity
B	0009252	biological_process	peptidoglycan biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016829	molecular_function	lyase activity
B	0019752	biological_process	carboxylic acid metabolic process
B	0030170	molecular_function	pyridoxal phosphate binding
B	0046394	biological_process	carboxylic acid biosynthetic process
B	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0046656	biological_process	folic acid biosynthetic process
B	0047810	molecular_function	D-alanine-2-oxoglutarate aminotransferase activity
C	0003824	molecular_function	catalytic activity
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0008360	biological_process	regulation of cell shape
C	0008483	molecular_function	transaminase activity
C	0008696	molecular_function	4-amino-4-deoxychorismate lyase activity
C	0009252	biological_process	peptidoglycan biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016829	molecular_function	lyase activity
C	0019752	biological_process	carboxylic acid metabolic process
C	0030170	molecular_function	pyridoxal phosphate binding
C	0046394	biological_process	carboxylic acid biosynthetic process
C	0046654	biological_process	tetrahydrofolate biosynthetic process
C	0046656	biological_process	folic acid biosynthetic process
C	0047810	molecular_function	D-alanine-2-oxoglutarate aminotransferase activity
D	0003824	molecular_function	catalytic activity
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0008360	biological_process	regulation of cell shape
D	0008483	molecular_function	transaminase activity
D	0008696	molecular_function	4-amino-4-deoxychorismate lyase activity
D	0009252	biological_process	peptidoglycan biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016829	molecular_function	lyase activity
D	0019752	biological_process	carboxylic acid metabolic process
D	0030170	molecular_function	pyridoxal phosphate binding
D	0046394	biological_process	carboxylic acid biosynthetic process
D	0046654	biological_process	tetrahydrofolate biosynthetic process
D	0046656	biological_process	folic acid biosynthetic process
D	0047810	molecular_function	D-alanine-2-oxoglutarate aminotransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue PMP A 301

Chain	Residue
A	ARG50
A	GLY215
A	THR216
A	THR217
A	SER252
A	SER253
A	AKG302
A	HOH404
A	HOH411
A	HOH419
A	HOH435
A	TYR153
A	GLU182
A	GLY183
A	PRO184
A	ARG185
A	SER186
A	THR187
A	LEU213

---

site_id	AC2
Number of Residues	11
Details	binding site for residue AKG A 302

Chain	Residue
A	PHE31
A	THR33
A	ARG115
A	LYS149
A	SER252
A	SER253
A	MET254
A	THR255
A	PMP301
A	HOH411
B	ARG26

---

site_id	AC3
Number of Residues	16
Details	binding site for residue PMP B 301

Chain	Residue
B	ARG50
B	LYS149
B	TYR153
B	GLU182
B	GLY183
B	ARG185
B	SER186
B	THR187
B	LEU213
B	THR216
B	THR217
B	VAL251
B	SER252
B	SER253
B	AKG302
B	HOH442

---

site_id	AC4
Number of Residues	8
Details	binding site for residue AKG B 302

Chain	Residue
A	ARG26
B	ARG115
B	MET157
B	ARG185
B	MET254
B	THR255
B	PMP301
B	HOH402

---

site_id	AC5
Number of Residues	17
Details	binding site for residue PMP C 301

Chain	Residue
C	ARG50
C	LYS149
C	TYR153
C	GLU182
C	PRO184
C	ARG185
C	SER186
C	THR187
C	LEU213
C	GLY215
C	THR216
C	THR217
C	SER252
C	SER253
C	AKG302
C	HOH452
C	HOH466

---

site_id	AC6
Number of Residues	6
Details	binding site for residue AKG C 302

Chain	Residue
C	ARG115
C	SER252
C	MET254
C	THR255
C	PMP301
C	HOH452

---

site_id	AC7
Number of Residues	5
Details	binding site for residue CIT C 303

Chain	Residue
A	LEU65
A	PRO66
A	ARG69
A	ARG238
C	ARG121

---

site_id	AC8
Number of Residues	4
Details	binding site for residue CIT C 304

Chain	Residue
A	ARG121
C	LEU65
C	ARG69
C	ARG238

---

site_id	AC9
Number of Residues	16
Details	binding site for residue PMP D 301

Chain	Residue
D	AKG302
D	HOH403
D	HOH417
D	ARG50
D	TYR153
D	GLU182
D	PRO184
D	ARG185
D	SER186
D	THR187
D	LEU213
D	GLY215
D	THR216
D	THR217
D	SER252
D	SER253

---

site_id	AD1
Number of Residues	8
Details	binding site for residue AKG D 302

Chain	Residue
C	ARG26
D	THR33
D	ARG115
D	SER252
D	MET254
D	THR255
D	PMP301
D	HOH417

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33950161","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6Q1R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q1S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33950161","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6Q1S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Important for dual ACDL/DAAT activities","evidences":[{"source":"PubMed","id":"33950161","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"PubMed","id":"33950161","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6Q1R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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