6Q1R
A hypothetical aminotransferase from Mycobacterium tuberculosis, PLP-bound form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0008696 | molecular_function | 4-amino-4-deoxychorismate lyase activity |
| A | 0009252 | biological_process | peptidoglycan biosynthetic process |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0046394 | biological_process | carboxylic acid biosynthetic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
| A | 0047810 | molecular_function | D-alanine:2-oxoglutarate transaminase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0008696 | molecular_function | 4-amino-4-deoxychorismate lyase activity |
| B | 0009252 | biological_process | peptidoglycan biosynthetic process |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0046394 | biological_process | carboxylic acid biosynthetic process |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046656 | biological_process | folic acid biosynthetic process |
| B | 0047810 | molecular_function | D-alanine:2-oxoglutarate transaminase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0008696 | molecular_function | 4-amino-4-deoxychorismate lyase activity |
| C | 0009252 | biological_process | peptidoglycan biosynthetic process |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0046394 | biological_process | carboxylic acid biosynthetic process |
| C | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| C | 0046656 | biological_process | folic acid biosynthetic process |
| C | 0047810 | molecular_function | D-alanine:2-oxoglutarate transaminase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0008696 | molecular_function | 4-amino-4-deoxychorismate lyase activity |
| D | 0009252 | biological_process | peptidoglycan biosynthetic process |
| D | 0030170 | molecular_function | pyridoxal phosphate binding |
| D | 0046394 | biological_process | carboxylic acid biosynthetic process |
| D | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| D | 0046656 | biological_process | folic acid biosynthetic process |
| D | 0047810 | molecular_function | D-alanine:2-oxoglutarate transaminase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue PLP A 301 |
| Chain | Residue |
| A | HIS47 |
| A | LEU213 |
| A | GLY215 |
| A | THR216 |
| A | THR217 |
| A | SER253 |
| A | HOH420 |
| A | ARG50 |
| A | LYS149 |
| A | TYR153 |
| A | GLU182 |
| A | GLY183 |
| A | PRO184 |
| A | SER186 |
| A | THR187 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue CIT A 302 |
| Chain | Residue |
| A | LEU65 |
| A | ARG69 |
| A | ARG238 |
| C | ARG121 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 303 |
| Chain | Residue |
| A | TYR179 |
| A | TYR210 |
| A | HOH417 |
| C | HIS261 |
| C | ARG267 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue CIT C 302 |
| Chain | Residue |
| A | ARG121 |
| C | LEU65 |
| C | PRO66 |
| C | ARG69 |
| C | ARG238 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide PLP B 301 and LYS B 149 |
| Chain | Residue |
| B | VAL30 |
| B | PHE31 |
| B | ARG50 |
| B | SER54 |
| B | ALA148 |
| B | THR150 |
| B | TYR153 |
| B | GLU182 |
| B | GLY183 |
| B | PRO184 |
| B | SER186 |
| B | LEU213 |
| B | THR216 |
| B | THR217 |
| B | SER252 |
| B | SER253 |
| site_id | AC6 |
| Number of Residues | 18 |
| Details | binding site for Di-peptide PLP C 301 and LYS C 149 |
| Chain | Residue |
| C | VAL30 |
| C | PHE31 |
| C | HIS47 |
| C | ARG50 |
| C | SER54 |
| C | ALA148 |
| C | THR150 |
| C | TYR153 |
| C | GLU182 |
| C | GLY183 |
| C | PRO184 |
| C | SER186 |
| C | THR187 |
| C | LEU213 |
| C | THR216 |
| C | THR217 |
| C | SER252 |
| C | SER253 |
| site_id | AC7 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide PLP D 301 and LYS D 149 |
| Chain | Residue |
| D | VAL30 |
| D | PHE31 |
| D | ARG50 |
| D | SER54 |
| D | ALA148 |
| D | THR150 |
| D | TYR153 |
| D | GLU182 |
| D | GLY183 |
| D | PRO184 |
| D | ARG185 |
| D | SER186 |
| D | THR187 |
| D | LEU213 |
| D | GLY215 |
| D | THR216 |
| D | THR217 |
| D | SER252 |
| D | SER253 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"33950161","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6Q1R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q1S","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"33950161","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6Q1S","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Important for dual ACDL/DAAT activities","evidences":[{"source":"PubMed","id":"33950161","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"PubMed","id":"33950161","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6Q1R","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
