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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6Q0T

Structure of a MAPK pathway complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000165biological_processMAPK cascade
A0000166molecular_functionnucleotide binding
A0003824molecular_functioncatalytic activity
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004708molecular_functionMAP kinase kinase activity
A0004709molecular_functionMAP kinase kinase kinase activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006468biological_processprotein phosphorylation
A0007165biological_processsignal transduction
A0007173biological_processepidermal growth factor receptor signaling pathway
A0008270molecular_functionzinc ion binding
A0009887biological_processanimal organ morphogenesis
A0010628biological_processpositive regulation of gene expression
A0010828biological_processpositive regulation of D-glucose transmembrane transport
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0031267molecular_functionsmall GTPase binding
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0042802molecular_functionidentical protein binding
A0043005cellular_componentneuron projection
A0043066biological_processnegative regulation of apoptotic process
A0044297cellular_componentcell body
A0046872molecular_functionmetal ion binding
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0071277biological_processcellular response to calcium ion
A0090150biological_processestablishment of protein localization to membrane
A0097110molecular_functionscaffold protein binding
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099170biological_processpostsynaptic modulation of chemical synaptic transmission
A0106310molecular_functionprotein serine kinase activity
B0000165biological_processMAPK cascade
B0000166molecular_functionnucleotide binding
B0003824molecular_functioncatalytic activity
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004708molecular_functionMAP kinase kinase activity
B0004709molecular_functionMAP kinase kinase kinase activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006468biological_processprotein phosphorylation
B0007165biological_processsignal transduction
B0007173biological_processepidermal growth factor receptor signaling pathway
B0008270molecular_functionzinc ion binding
B0009887biological_processanimal organ morphogenesis
B0010628biological_processpositive regulation of gene expression
B0010828biological_processpositive regulation of D-glucose transmembrane transport
B0016301molecular_functionkinase activity
B0016740molecular_functiontransferase activity
B0031267molecular_functionsmall GTPase binding
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0042802molecular_functionidentical protein binding
B0043005cellular_componentneuron projection
B0043066biological_processnegative regulation of apoptotic process
B0044297cellular_componentcell body
B0046872molecular_functionmetal ion binding
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0071277biological_processcellular response to calcium ion
B0090150biological_processestablishment of protein localization to membrane
B0097110molecular_functionscaffold protein binding
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099170biological_processpostsynaptic modulation of chemical synaptic transmission
B0106310molecular_functionprotein serine kinase activity
C0000165biological_processMAPK cascade
C0000166molecular_functionnucleotide binding
C0000187biological_processobsolete activation of MAPK activity
C0003056biological_processregulation of vascular associated smooth muscle contraction
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004708molecular_functionMAP kinase kinase activity
C0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
C0004713molecular_functionprotein tyrosine kinase activity
C0005078molecular_functionMAP-kinase scaffold activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005769cellular_componentearly endosome
C0005770cellular_componentlate endosome
C0005783cellular_componentendoplasmic reticulum
C0005794cellular_componentGolgi apparatus
C0005813cellular_componentcentrosome
C0005829cellular_componentcytosol
C0005874cellular_componentmicrotubule
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0005938cellular_componentcell cortex
C0006468biological_processprotein phosphorylation
C0006935biological_processchemotaxis
C0006979biological_processresponse to oxidative stress
C0007165biological_processsignal transduction
C0007528biological_processneuromuscular junction development
C0008285biological_processnegative regulation of cell population proliferation
C0010508biological_processpositive regulation of autophagy
C0010628biological_processpositive regulation of gene expression
C0010629biological_processnegative regulation of gene expression
C0014044biological_processSchwann cell development
C0014069cellular_componentpostsynaptic density
C0016020cellular_componentmembrane
C0016301molecular_functionkinase activity
C0016740molecular_functiontransferase activity
C0019901molecular_functionprotein kinase binding
C0030182biological_processneuron differentiation
C0030295molecular_functionprotein kinase activator activity
C0030335biological_processpositive regulation of cell migration
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0031267molecular_functionsmall GTPase binding
C0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
C0032402biological_processmelanosome transport
C0032839cellular_componentdendrite cytoplasm
C0032872biological_processregulation of stress-activated MAPK cascade
C0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
C0034111biological_processnegative regulation of homotypic cell-cell adhesion
C0036064cellular_componentciliary basal body
C0038127biological_processERBB signaling pathway
C0038133biological_processERBB2-ERBB3 signaling pathway
C0042552biological_processmyelination
C0043204cellular_componentperikaryon
C0043410biological_processpositive regulation of MAPK cascade
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0044877molecular_functionprotein-containing complex binding
C0045893biological_processpositive regulation of DNA-templated transcription
C0045933biological_processpositive regulation of muscle contraction
C0047496biological_processvesicle transport along microtubule
C0048009biological_processinsulin-like growth factor receptor signaling pathway
C0048313biological_processGolgi inheritance
C0048471cellular_componentperinuclear region of cytoplasm
C0048678biological_processresponse to axon injury
C0048812biological_processneuron projection morphogenesis
C0051384biological_processresponse to glucocorticoid
C0070328biological_processtriglyceride homeostasis
C0070371biological_processERK1 and ERK2 cascade
C0070372biological_processregulation of ERK1 and ERK2 cascade
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0090170biological_processregulation of Golgi inheritance
C0090398biological_processcellular senescence
C0097110molecular_functionscaffold protein binding
C0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
C0098978cellular_componentglutamatergic synapse
C0106310molecular_functionprotein serine kinase activity
C1903298biological_processnegative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
C2000641biological_processregulation of early endosome to late endosome transport
C2001171biological_processpositive regulation of ATP biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues2
Detailsbinding site for residue MG C 401
ChainResidue
CLCJ402
CAGS403
site_idAC2
Number of Residues9
Detailsbinding site for residue LCJ C 402
ChainResidue
CMG401
CAGS403
CGLY80
CILE141
CASP208
CPHE209
CGLY210
CVAL211
CSER212
site_idAC3
Number of Residues10
Detailsbinding site for residue AGS C 403
ChainResidue
CGLY77
CASN78
CVAL82
CALA95
CGLU144
CMET146
CSER150
CSER194
CMG401
CLCJ402
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues21
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGTVYkGkwhgd.............VAVK
ChainResidueDetails
AILE463-LYS483
CLEU74-LYS97
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKsnNIFL
ChainResidueDetails
AILE572-LEU584
CILE186-VAL198
site_idPS00479
Number of Residues46
DetailsZF_DAG_PE_1 Zinc finger phorbol-ester/DAG-type signature. HnFvrktfftlaf.CdfCrklLfqgfr.....CqtCgykfHqrCstevplm..C
ChainResidueDetails
AHIS235-CYS280
site_idPS00796
Number of Residues11
Details1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
ChainResidueDetails
XARG41-VAL51
site_idPS00797
Number of Residues20
Details1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS
ChainResidueDetails
XTYR211-SER230
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"Omega-N-methylarginine; by PRMT5","evidences":[{"source":"PubMed","id":"21917714","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Boldt K.","von Kriegsheim A.F.","Zebisch A.","Kolch W."]}},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23907581","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues18
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15543157","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17880056","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18951019","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19019675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19706763","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21310613","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19161339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3EQH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19161339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3EQF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by BRAF and RAF1","evidences":[{"source":"PubMed","id":"10409742","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20956560","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29433126","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8131746","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by BRAF and RAF1","evidences":[{"source":"PubMed","id":"20956560","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29433126","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8131746","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

248335

PDB entries from 2026-01-28

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