6PZI

Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP only

Functional Information from GO Data

Chain	GOid	namespace	contents
G	0005267	molecular_function	potassium channel activity
G	0005524	molecular_function	ATP binding
G	0005886	cellular_component	plasma membrane
G	0006813	biological_process	potassium ion transport
G	0008281	molecular_function	sulfonylurea receptor activity
G	0016020	cellular_component	membrane
G	0016887	molecular_function	ATP hydrolysis activity
G	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
G	0055085	biological_process	transmembrane transport
G	0071805	biological_process	potassium ion transmembrane transport
G	0140359	molecular_function	ABC-type transporter activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue ATP G 1601

Chain	Residue
G	SER405
G	TRP688
G	GLY716
G	CYS717
G	GLY718
G	LYS719
G	SER720
G	GLN775

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Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQRISVARAL

Chain	Residue	Details
G	LEU830-LEU844
G	PHE1482-PHE1496

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	98
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:10506167

Chain	Residue	Details
G	MET1-VAL34
G	GLY97-SER101
G	VAL155-LEU167
G	LEU1027-SER1073
G	ARG1274-SER1277

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
G	PRO35-SER55

---

site_id	SWS_FT_FI3
Number of Residues	828
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:10506167

Chain	Residue	Details
G	SER56-TRP75
G	TYR123-LYS134
G	TYR195-LEU311
G	SER606-LEU1005
G	VAL1299-LYS1582

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
G	ILE76-ASP96

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
G	ARG102-VAL122

---

site_id	SWS_FT_FI6
Number of Residues	19
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
G	LEU135-PHE154

---

site_id	SWS_FT_FI7
Number of Residues	26
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
G	ARG168-ARG194

---

site_id	SWS_FT_FI8
Number of Residues	19
Details	TRANSMEM: Helical; Name=6 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
G	LEU312-ASN331

---

site_id	SWS_FT_FI9
Number of Residues	47
Details	TOPO_DOM: Extracellular => ECO:0000250

Chain	Residue	Details
G	HIS332-ALA355
G	LEU456-VAL458
G	VAL563-HIS584
G	VAL1160

---

site_id	SWS_FT_FI10
Number of Residues	20
Details	TRANSMEM: Helical; Name=7 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
G	TYR356-SER376

---

site_id	SWS_FT_FI11
Number of Residues	231
Details	TOPO_DOM: Cytoplasmic => ECO:0000250

Chain	Residue	Details
G	TYR377-LEU434
G	LYS480-SER541
G	LYS1095-SER1138
G	PHE1182-MET1252

---

site_id	SWS_FT_FI12
Number of Residues	20
Details	TRANSMEM: Helical; Name=8 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
G	CYS435-ILE455

---

site_id	SWS_FT_FI13
Number of Residues	20
Details	TRANSMEM: Helical; Name=9 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
G	SER459-THR479

---

site_id	SWS_FT_FI14
Number of Residues	20
Details	TRANSMEM: Helical; Name=10 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
G	ILE542-HIS562

---

site_id	SWS_FT_FI15
Number of Residues	20
Details	TRANSMEM: Helical; Name=11 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
G	ILE585-VAL605

---

site_id	SWS_FT_FI16
Number of Residues	20
Details	TRANSMEM: Helical; Name=12

Chain	Residue	Details
G	SER1006-VAL1026

---

site_id	SWS_FT_FI17
Number of Residues	20
Details	TRANSMEM: Helical; Name=13 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
G	LEU1074-ALA1094

---

site_id	SWS_FT_FI18
Number of Residues	20
Details	TRANSMEM: Helical; Name=14 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
G	THR1139-TYR1159

---

site_id	SWS_FT_FI19
Number of Residues	20
Details	TRANSMEM: Helical; Name=15 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
G	THR1161-TYR1181

---

site_id	SWS_FT_FI20
Number of Residues	20
Details	TRANSMEM: Helical; Name=16 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
G	GLU1253-HIS1273

---

site_id	SWS_FT_FI21
Number of Residues	20
Details	TRANSMEM: Helical; Name=17

Chain	Residue	Details
G	ALA1278-MET1298

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434

Chain	Residue	Details
G	GLY713
G	GLY1379

---

site_id	SWS_FT_FI23
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10506167, ECO:0000269|PubMed:8942641

Chain	Residue	Details
G	ASN10

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine

Chain	Residue	Details
G	ASN1050

---