6PZI

Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP only

Functional Information from GO Data

Chain	GOid	namespace	contents
G	0000166	molecular_function	nucleotide binding
G	0005267	molecular_function	potassium channel activity
G	0005524	molecular_function	ATP binding
G	0005886	cellular_component	plasma membrane
G	0006813	biological_process	potassium ion transport
G	0008281	molecular_function	sulfonylurea receptor activity
G	0009410	biological_process	response to xenobiotic stimulus
G	0016020	cellular_component	membrane
G	0016887	molecular_function	ATP hydrolysis activity
G	0022857	molecular_function	transmembrane transporter activity
G	0032991	cellular_component	protein-containing complex
G	0033198	biological_process	response to ATP
G	0042383	cellular_component	sarcolemma
G	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
G	0046872	molecular_function	metal ion binding
G	0055085	biological_process	transmembrane transport
G	0071805	biological_process	potassium ion transmembrane transport
G	0140359	molecular_function	ABC-type transporter activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue ATP G 1601

Chain	Residue
G	SER405
G	TRP688
G	GLY716
G	CYS717
G	GLY718
G	LYS719
G	SER720
G	GLN775

---

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQRISVARAL

Chain	Residue	Details
G	LEU830-LEU844
G	PHE1482-PHE1496

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	75
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"10506167","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	128
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"10506167","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	15
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	60
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	15
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	263
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	15
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	12
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	15
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	15
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=13","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=14","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	12
Details	Transmembrane: {"description":"Helical; Name=15","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	15
Details	Transmembrane: {"description":"Helical; Name=16","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	15
Details	Transmembrane: {"description":"Helical; Name=17","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	303
Details	Domain: {"description":"ABC transmembrane type-1 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10506167","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8942641","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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