6PZC
Cryo-EM structure of the pancreatic beta-cell SUR1 bound to carbamazepine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| H | 0000166 | molecular_function | nucleotide binding |
| H | 0005267 | molecular_function | potassium channel activity |
| H | 0005524 | molecular_function | ATP binding |
| H | 0005886 | cellular_component | plasma membrane |
| H | 0006813 | biological_process | potassium ion transport |
| H | 0008281 | molecular_function | sulfonylurea receptor activity |
| H | 0009410 | biological_process | response to xenobiotic stimulus |
| H | 0016020 | cellular_component | membrane |
| H | 0016887 | molecular_function | ATP hydrolysis activity |
| H | 0022857 | molecular_function | transmembrane transporter activity |
| H | 0032991 | cellular_component | protein-containing complex |
| H | 0033198 | biological_process | response to ATP |
| H | 0042383 | cellular_component | sarcolemma |
| H | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0055085 | biological_process | transmembrane transport |
| H | 0071805 | biological_process | potassium ion transmembrane transport |
| H | 0140359 | molecular_function | ABC-type transporter activity |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQRISVARAL |
| Chain | Residue | Details |
| H | LEU830-LEU844 | |
| H | PHE1482-PHE1496 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 15 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 15 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 263 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 15 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 24 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 15 |
| Details | Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 15 |
| Details | Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 16 |
| Details | Transmembrane: {"description":"Helical; Name=13","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=14","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 12 |
| Details | Transmembrane: {"description":"Helical; Name=15","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 15 |
| Details | Transmembrane: {"description":"Helical; Name=16","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 15 |
| Details | Transmembrane: {"description":"Helical; Name=17","evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q09428","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
