6PZ9
Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and repaglinide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0005267 | molecular_function | potassium channel activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006813 | biological_process | potassium ion transport |
| C | 0008281 | molecular_function | sulfonylurea receptor activity |
| C | 0016020 | cellular_component | membrane |
| C | 0016887 | molecular_function | ATP hydrolysis activity |
| C | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0071805 | biological_process | potassium ion transmembrane transport |
| C | 0140359 | molecular_function | ABC-type transporter activity |
| D | 0001508 | biological_process | action potential |
| D | 0001666 | biological_process | response to hypoxia |
| D | 0001669 | cellular_component | acrosomal vesicle |
| D | 0002931 | biological_process | response to ischemia |
| D | 0003229 | biological_process | ventricular cardiac muscle tissue development |
| D | 0005242 | molecular_function | inward rectifier potassium channel activity |
| D | 0005249 | molecular_function | voltage-gated potassium channel activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005635 | cellular_component | nuclear envelope |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005768 | cellular_component | endosome |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006006 | biological_process | glucose metabolic process |
| D | 0006813 | biological_process | potassium ion transport |
| D | 0006915 | biological_process | apoptotic process |
| D | 0006950 | biological_process | response to stress |
| D | 0008282 | cellular_component | inward rectifying potassium channel |
| D | 0008340 | biological_process | determination of adult lifespan |
| D | 0009410 | biological_process | response to xenobiotic stimulus |
| D | 0014704 | cellular_component | intercalated disc |
| D | 0015272 | molecular_function | ATP-activated inward rectifier potassium channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0019829 | molecular_function | ATPase-coupled monoatomic cation transmembrane transporter activity |
| D | 0030315 | cellular_component | T-tubule |
| D | 0030506 | molecular_function | ankyrin binding |
| D | 0030673 | cellular_component | axolemma |
| D | 0031072 | molecular_function | heat shock protein binding |
| D | 0031669 | biological_process | cellular response to nutrient levels |
| D | 0032355 | biological_process | response to estradiol |
| D | 0033198 | biological_process | response to ATP |
| D | 0033574 | biological_process | response to testosterone |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0034702 | cellular_component | monoatomic ion channel complex |
| D | 0034765 | biological_process | regulation of monoatomic ion transmembrane transport |
| D | 0042383 | cellular_component | sarcolemma |
| D | 0042391 | biological_process | regulation of membrane potential |
| D | 0042734 | cellular_component | presynaptic membrane |
| D | 0043025 | cellular_component | neuronal cell body |
| D | 0044325 | molecular_function | transmembrane transporter binding |
| D | 0046676 | biological_process | negative regulation of insulin secretion |
| D | 0050796 | biological_process | regulation of insulin secretion |
| D | 0050877 | biological_process | nervous system process |
| D | 0061762 | biological_process | CAMKK-AMPK signaling cascade |
| D | 0070852 | cellular_component | cell body fiber |
| D | 0071316 | biological_process | cellular response to nicotine |
| D | 0071333 | biological_process | cellular response to glucose stimulus |
| D | 0071356 | biological_process | cellular response to tumor necrosis factor |
| D | 0071805 | biological_process | potassium ion transmembrane transport |
| D | 0098662 | biological_process | inorganic cation transmembrane transport |
| D | 0098978 | cellular_component | glutamatergic synapse |
| D | 0099505 | biological_process | regulation of presynaptic membrane potential |
| D | 0099508 | molecular_function | voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential |
| D | 1903078 | biological_process | positive regulation of protein localization to plasma membrane |
| D | 1904638 | biological_process | response to resveratrol |
| D | 1990573 | biological_process | potassium ion import across plasma membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue ATP C 1602 |
| Chain | Residue |
| C | THR404 |
| C | SER720 |
| C | SER721 |
| C | GLN775 |
| C | SER405 |
| C | ASN406 |
| C | TRP688 |
| C | VAL715 |
| C | GLY716 |
| C | CYS717 |
| C | GLY718 |
| C | LYS719 |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQRISVARAL |
| Chain | Residue | Details |
| C | LEU830-LEU844 | |
| C | PHE1482-PHE1496 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 290 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250 |
| Chain | Residue | Details |
| D | MET1-TRP68 | |
| D | ILE167-SER390 | |
| C | VAL155-LEU167 | |
| C | LEU1027-SER1073 | |
| C | ARG1274-SER1277 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=M1 => ECO:0000250 |
| Chain | Residue | Details |
| D | PRO69-ILE93 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 30 |
| Details | TOPO_DOM: Extracellular => ECO:0000250 |
| Chain | Residue | Details |
| D | ALA94-SER116 | |
| D | ARG136-LEU144 | |
| C | TYR195-LEU311 | |
| C | SER606-LEU1005 | |
| C | VAL1299-LYS1582 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 11 |
| Details | INTRAMEM: Helical; Pore-forming; Name=H5 => ECO:0000250 |
| Chain | Residue | Details |
| D | PHE117-GLN128 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | INTRAMEM: Pore-forming => ECO:0000250 |
| Chain | Residue | Details |
| D | VAL129-GLY135 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=M2 => ECO:0000250 |
| Chain | Residue | Details |
| D | ALA145-CYS166 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | SITE: Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium => ECO:0000250 |
| Chain | Residue | Details |
| D | ASN160 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by MAPK1 => ECO:0000250|UniProtKB:Q14654 |
| Chain | Residue | Details |
| D | THR341 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by MAPK1 => ECO:0000250|UniProtKB:Q14654 |
| Chain | Residue | Details |
| D | SER385 | |
| C | LEU456-VAL458 | |
| C | VAL563-HIS584 | |
| C | VAL1160 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| C | TYR356-SER376 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 231 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250 |
| Chain | Residue | Details |
| C | TYR377-LEU434 | |
| C | LYS480-SER541 | |
| C | LYS1095-SER1138 | |
| C | PHE1182-MET1252 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| C | CYS435-ILE455 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| C | SER459-THR479 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| C | ILE542-HIS562 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| C | ILE585-VAL605 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=12 |
| Chain | Residue | Details |
| C | SER1006-VAL1026 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=13 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| C | LEU1074-ALA1094 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=14 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| C | THR1139-TYR1159 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=15 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| C | THR1161-TYR1181 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=16 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| C | GLU1253-HIS1273 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=17 |
| Chain | Residue | Details |
| C | ALA1278-MET1298 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 |
| Chain | Residue | Details |
| C | GLY713 | |
| C | GLY1379 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10506167, ECO:0000269|PubMed:8942641 |
| Chain | Residue | Details |
| C | ASN10 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine |
| Chain | Residue | Details |
| C | ASN1050 |
