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6PXN

Human Casein Kinase 1 delta Tau mutant (R178C)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001934biological_processpositive regulation of protein phosphorylation
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005794cellular_componentGolgi apparatus
A0005813cellular_componentcentrosome
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005876cellular_componentspindle microtubule
A0005886cellular_componentplasma membrane
A0006338biological_processchromatin remodeling
A0006468biological_processprotein phosphorylation
A0006897biological_processendocytosis
A0007020biological_processmicrotubule nucleation
A0007030biological_processGolgi organization
A0007165biological_processsignal transduction
A0016055biological_processWnt signaling pathway
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
A0032922biological_processcircadian regulation of gene expression
A0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
A0034067biological_processprotein localization to Golgi apparatus
A0036064cellular_componentciliary basal body
A0042752biological_processregulation of circadian rhythm
A0044024molecular_functionhistone H2AS1 kinase activity
A0045296molecular_functioncadherin binding
A0048208biological_processCOPII vesicle coating
A0048471cellular_componentperinuclear region of cytoplasm
A0048511biological_processrhythmic process
A0050321molecular_functiontau-protein kinase activity
A0051225biological_processspindle assembly
A0061512biological_processprotein localization to cilium
A0071539biological_processprotein localization to centrosome
A0090263biological_processpositive regulation of canonical Wnt signaling pathway
A0106310molecular_functionprotein serine kinase activity
A1904948biological_processmidbrain dopaminergic neuron differentiation
A1905515biological_processnon-motile cilium assembly
A1990090biological_processcellular response to nerve growth factor stimulus
A2000052biological_processpositive regulation of non-canonical Wnt signaling pathway
B0001934biological_processpositive regulation of protein phosphorylation
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005794cellular_componentGolgi apparatus
B0005813cellular_componentcentrosome
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005876cellular_componentspindle microtubule
B0005886cellular_componentplasma membrane
B0006338biological_processchromatin remodeling
B0006468biological_processprotein phosphorylation
B0006897biological_processendocytosis
B0007020biological_processmicrotubule nucleation
B0007030biological_processGolgi organization
B0007165biological_processsignal transduction
B0016055biological_processWnt signaling pathway
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0032922biological_processcircadian regulation of gene expression
B0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
B0034067biological_processprotein localization to Golgi apparatus
B0036064cellular_componentciliary basal body
B0042752biological_processregulation of circadian rhythm
B0044024molecular_functionhistone H2AS1 kinase activity
B0045296molecular_functioncadherin binding
B0048208biological_processCOPII vesicle coating
B0048471cellular_componentperinuclear region of cytoplasm
B0048511biological_processrhythmic process
B0050321molecular_functiontau-protein kinase activity
B0051225biological_processspindle assembly
B0061512biological_processprotein localization to cilium
B0071539biological_processprotein localization to centrosome
B0090263biological_processpositive regulation of canonical Wnt signaling pathway
B0106310molecular_functionprotein serine kinase activity
B1904948biological_processmidbrain dopaminergic neuron differentiation
B1905515biological_processnon-motile cilium assembly
B1990090biological_processcellular response to nerve growth factor stimulus
B2000052biological_processpositive regulation of non-canonical Wnt signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue SO4 A 501
ChainResidue
AARG157
AARG192
AHOH632
AHOH643

site_idAC2
Number of Residues4
Detailsbinding site for residue SO4 A 502
ChainResidue
ASER267
AARG270
AGLN271
AARG274

site_idAC3
Number of Residues3
Detailsbinding site for residue SO4 B 501
ChainResidue
BLYS154
BLYS171
BARG127

site_idAC4
Number of Residues3
Detailsbinding site for residue SO4 B 502
ChainResidue
BSER267
BARG270
BARG274

site_idAC5
Number of Residues3
Detailsbinding site for residue SO4 B 503
ChainResidue
BARG157
BARG192
BLYS263

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGDIYlGtdiaagee..........VAIK
ChainResidueDetails
AILE15-LYS38

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. FiHrDVKpdNFLM
ChainResidueDetails
APHE124-MET136

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP128
BASP128

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AILE15
ALYS38
BILE15
BLYS38

site_idSWS_FT_FI3
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER328
ASER382
ASER407
BSER328
BSER382
BSER407

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER331
ASER384
BSER331
BSER384

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q06486
ChainResidueDetails
ASER370
BSER370

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q9DC28
ChainResidueDetails
AARG375
BARG375

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332
ChainResidueDetails
ASER383
BSER383

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195
ChainResidueDetails
ASER411
BSER411

225158

PDB entries from 2024-09-18

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