Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6PX2

Acropora millepora GAPDH

Replaces: 6DFZ

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A	0005829	cellular_component	cytosol
A	0006006	biological_process	glucose metabolic process
A	0006096	biological_process	glycolytic process
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
B	0000166	molecular_function	nucleotide binding
B	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B	0005829	cellular_component	cytosol
B	0006006	biological_process	glucose metabolic process
B	0006096	biological_process	glycolytic process
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0050661	molecular_function	NADP binding
B	0051287	molecular_function	NAD binding
C	0000166	molecular_function	nucleotide binding
C	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C	0005829	cellular_component	cytosol
C	0006006	biological_process	glucose metabolic process
C	0006096	biological_process	glycolytic process
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0050661	molecular_function	NADP binding
C	0051287	molecular_function	NAD binding
D	0000166	molecular_function	nucleotide binding
D	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D	0005829	cellular_component	cytosol
D	0006006	biological_process	glucose metabolic process
D	0006096	biological_process	glycolytic process
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0050661	molecular_function	NADP binding
D	0051287	molecular_function	NAD binding
E	0000166	molecular_function	nucleotide binding
E	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E	0005829	cellular_component	cytosol
E	0006006	biological_process	glucose metabolic process
E	0006096	biological_process	glycolytic process
E	0016491	molecular_function	oxidoreductase activity
E	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E	0050661	molecular_function	NADP binding
E	0051287	molecular_function	NAD binding
F	0000166	molecular_function	nucleotide binding
F	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F	0005829	cellular_component	cytosol
F	0006006	biological_process	glucose metabolic process
F	0006096	biological_process	glycolytic process
F	0016491	molecular_function	oxidoreductase activity
F	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F	0050661	molecular_function	NADP binding
F	0051287	molecular_function	NAD binding
G	0000166	molecular_function	nucleotide binding
G	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G	0005829	cellular_component	cytosol
G	0006006	biological_process	glucose metabolic process
G	0006096	biological_process	glycolytic process
G	0016491	molecular_function	oxidoreductase activity
G	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
G	0050661	molecular_function	NADP binding
G	0051287	molecular_function	NAD binding
H	0000166	molecular_function	nucleotide binding
H	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H	0005829	cellular_component	cytosol
H	0006006	biological_process	glucose metabolic process
H	0006096	biological_process	glycolytic process
H	0016491	molecular_function	oxidoreductase activity
H	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
H	0050661	molecular_function	NADP binding
H	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	binding site for residue NAD A 401

Chain	Residue
A	ASN7
A	PHE35
A	LYS78
A	SER96
A	THR97
A	GLY98
A	PHE100
A	SER120
A	ALA121
A	CYS151
A	ALA182
A	GLY8
A	ASN315
A	HOH501
A	HOH510
A	HOH512
A	PHE9
A	GLY10
A	ARG11
A	ILE12
A	ASN32
A	ASP33
A	PRO34

site_id	AC2
Number of Residues	6
Details	binding site for residue PO4 A 402

Chain	Residue
A	SER150
A	CYS151
A	THR152
A	HIS178
A	THR210
A	GLY211

site_id	AC3
Number of Residues	15
Details	binding site for residue NAD B 401

Chain	Residue
B	ASN7
B	GLY10
B	ARG11
B	ILE12
B	ASP33
B	PRO34
B	PHE35
B	SER96
B	THR97
B	GLY98
B	SER120
B	ALA121
B	CYS151
B	ASN315
B	HOH504

site_id	AC4
Number of Residues	6
Details	binding site for residue PO4 B 402

Chain	Residue
B	SER150
B	CYS151
B	THR152
B	HIS178
B	THR210
B	GLY211

site_id	AC5
Number of Residues	22
Details	binding site for residue NAD C 401

Chain	Residue
C	ASN7
C	GLY8
C	PHE9
C	GLY10
C	ARG11
C	ILE12
C	ASP33
C	PRO34
C	PHE35
C	ILE36
C	LYS78
C	SER96
C	THR97
C	GLY98
C	SER120
C	ALA121
C	CYS151
C	ALA182
C	ASN315
C	TYR319
C	HOH505
C	HOH519

site_id	AC6
Number of Residues	7
Details	binding site for residue PO4 C 402

Chain	Residue
C	SER150
C	CYS151
C	THR152
C	HIS178
C	THR210
C	GLY211
C	HOH509

site_id	AC7
Number of Residues	21
Details	binding site for residue NAD D 401

Chain	Residue
D	HOH503
D	ASN7
D	GLY8
D	PHE9
D	GLY10
D	ARG11
D	ILE12
D	ASN32
D	ASP33
D	PRO34
D	ILE36
D	LYS78
D	SER96
D	THR97
D	GLY98
D	PHE100
D	SER120
D	ALA121
D	CYS151
D	ALA182
D	ASN315

site_id	AC8
Number of Residues	6
Details	binding site for residue PO4 D 402

Chain	Residue
D	SER150
D	CYS151
D	THR152
D	HIS178
D	THR210
D	GLY211

site_id	AC9
Number of Residues	25
Details	binding site for residue NAD E 401

Chain	Residue
E	ASN7
E	GLY8
E	PHE9
E	GLY10
E	ARG11
E	ILE12
E	ASN32
E	ASP33
E	PRO34
E	PHE35
E	ILE36
E	LYS78
E	SER96
E	THR97
E	GLY98
E	PHE100
E	SER120
E	ALA121
E	CYS151
E	ALA182
E	ASN315
E	HOH503
E	HOH521
E	HOH527
E	HOH528

site_id	AD1
Number of Residues	7
Details	binding site for residue PO4 E 402

Chain	Residue
E	SER150
E	CYS151
E	THR152
E	HIS178
E	THR210
E	GLY211
E	HOH519

site_id	AD2
Number of Residues	16
Details	binding site for residue NAD F 401

Chain	Residue
F	GLY10
F	ARG11
F	ILE12
F	ASP33
F	PRO34
F	THR97
F	GLY98
F	VAL99
F	PHE100
F	SER120
F	ALA121
F	CYS151
F	ASN315
F	HOH504
F	HOH512
G	PRO190

site_id	AD3
Number of Residues	8
Details	binding site for residue PO4 F 402

Chain	Residue
F	SER150
F	CYS151
F	THR152
F	HIS178
F	THR210
F	GLY211
F	HOH505
F	HOH511

site_id	AD4
Number of Residues	21
Details	binding site for residue NAD G 401

Chain	Residue
G	ASN7
G	GLY8
G	GLY10
G	ARG11
G	ILE12
G	ASP33
G	PRO34
G	PHE35
G	ILE36
G	LYS78
G	SER96
G	THR97
G	GLY98
G	PHE100
G	SER120
G	ALA121
G	CYS151
G	ALA182
G	ASN315
G	TYR319
G	HOH516

site_id	AD5
Number of Residues	7
Details	binding site for residue PO4 G 402

Chain	Residue
G	SER150
G	CYS151
G	THR152
G	HIS178
G	THR210
G	GLY211
G	HOH509

site_id	AD6
Number of Residues	20
Details	binding site for residue NAD H 401

Chain	Residue
H	ASN7
H	GLY8
H	PHE9
H	GLY10
H	ARG11
H	ILE12
H	ASP33
H	PRO34
H	LYS78
H	SER96
H	THR97
H	GLY98
H	PHE100
H	SER120
H	ALA121
H	CYS151
H	ALA182
H	ASN315
H	TYR319
H	HOH520

site_id	AD7
Number of Residues	7
Details	binding site for residue PO4 H 402

Chain	Residue
H	SER150
H	CYS151
H	THR152
H	HIS178
H	THR210
H	GLY211
H	HOH511

Functional Information from PROSITE/UniProt

site_id	PS00071
Number of Residues	8
Details	GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL

Chain	Residue	Details
A	ALA149-LEU156

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)