Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6PWN

MscS Nanodisc with N-terminal His-Tag

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
A	0009992	biological_process	intracellular water homeostasis
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0051260	biological_process	protein homooligomerization
A	0055085	biological_process	transmembrane transport
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
B	0009992	biological_process	intracellular water homeostasis
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0051260	biological_process	protein homooligomerization
B	0055085	biological_process	transmembrane transport
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
C	0009992	biological_process	intracellular water homeostasis
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0051260	biological_process	protein homooligomerization
C	0055085	biological_process	transmembrane transport
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
D	0009992	biological_process	intracellular water homeostasis
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0051260	biological_process	protein homooligomerization
D	0055085	biological_process	transmembrane transport
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
E	0009992	biological_process	intracellular water homeostasis
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0042802	molecular_function	identical protein binding
E	0051260	biological_process	protein homooligomerization
E	0055085	biological_process	transmembrane transport
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
F	0009992	biological_process	intracellular water homeostasis
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0042802	molecular_function	identical protein binding
F	0051260	biological_process	protein homooligomerization
F	0055085	biological_process	transmembrane transport
G	0005886	cellular_component	plasma membrane
G	0006811	biological_process	monoatomic ion transport
G	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
G	0009992	biological_process	intracellular water homeostasis
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0042802	molecular_function	identical protein binding
G	0051260	biological_process	protein homooligomerization
G	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue POV A 301

Chain	Residue
A	TYR27
A	ILE31
A	GLY87
A	ARG88
A	VAL89
A	GLY90
B	ARG88

site_id	AC2
Number of Residues	2
Details	binding site for residue R16 A 302

Chain	Residue
B	R16302
F	R16302

site_id	AC3
Number of Residues	7
Details	binding site for residue POV B 301

Chain	Residue
B	TYR27
B	ILE31
B	GLY87
B	ARG88
B	VAL89
B	GLY90
C	ARG88

site_id	AC4
Number of Residues	2
Details	binding site for residue R16 B 302

Chain	Residue
A	R16302
C	R16303

site_id	AC5
Number of Residues	5
Details	binding site for residue POV C 301

Chain	Residue
C	TYR27
C	LEU86
C	VAL89
C	GLY90
D	ARG88

site_id	AC6
Number of Residues	4
Details	binding site for residue R16 C 302

Chain	Residue
C	GLN92
C	R16303
D	ILE97
E	R16302

site_id	AC7
Number of Residues	2
Details	binding site for residue R16 C 303

Chain	Residue
B	R16302
C	R16302

site_id	AC8
Number of Residues	7
Details	binding site for residue POV D 301

Chain	Residue
D	TYR27
D	GLY87
D	ARG88
D	VAL89
D	GLY90
E	ALA33
E	ARG88

site_id	AC9
Number of Residues	7
Details	binding site for residue POV E 301

Chain	Residue
E	TYR27
E	GLY87
E	ARG88
E	VAL89
E	GLY90
F	ILE37
F	ARG88

site_id	AD1
Number of Residues	3
Details	binding site for residue R16 E 302

Chain	Residue
C	R16302
D	GLN92
F	R16303

site_id	AD2
Number of Residues	7
Details	binding site for residue POV F 301

Chain	Residue
F	TYR27
F	ASN30
F	GLY87
F	ARG88
F	VAL89
F	GLY90
G	ARG88

site_id	AD3
Number of Residues	3
Details	binding site for residue R16 F 302

Chain	Residue
A	R16302
F	GLN92
G	ILE97

site_id	AD4
Number of Residues	1
Details	binding site for residue R16 F 303

Chain	Residue
E	R16302

site_id	AD5
Number of Residues	8
Details	binding site for residue POV G 301

Chain	Residue
A	ALA33
A	ARG88
G	TYR27
G	ASN30
G	GLY87
G	ARG88
G	VAL89
G	GLY90

Functional Information from PROSITE/UniProt

site_id	PS01246
Number of Residues	35
Details	UPF0003 Uncharacterized protein family UPF0003 signature. GTVlsVqifsttMrtaDgkiIvIPNgkIIagniiN

Chain	Residue	Details
A	GLY143-ASN177

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	210
Details	Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	427
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"12446901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26551077","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	98
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)