6PW5

Cryo-EM Structure of Thermo-Sensitive TRP Channel TRP1 from the Alga Chlamydomonas reinhardtii in Nanodiscs

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005262	molecular_function	calcium channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0015279	molecular_function	store-operated calcium channel activity
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034703	cellular_component	cation channel complex
A	0051480	biological_process	regulation of cytosolic calcium ion concentration
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0070679	molecular_function	inositol 1,4,5 trisphosphate binding
B	0005216	molecular_function	monoatomic ion channel activity
B	0005262	molecular_function	calcium channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0015279	molecular_function	store-operated calcium channel activity
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034703	cellular_component	cation channel complex
B	0051480	biological_process	regulation of cytosolic calcium ion concentration
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
B	0070679	molecular_function	inositol 1,4,5 trisphosphate binding
C	0005216	molecular_function	monoatomic ion channel activity
C	0005262	molecular_function	calcium channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0015279	molecular_function	store-operated calcium channel activity
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034703	cellular_component	cation channel complex
C	0051480	biological_process	regulation of cytosolic calcium ion concentration
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0070679	molecular_function	inositol 1,4,5 trisphosphate binding
D	0005216	molecular_function	monoatomic ion channel activity
D	0005262	molecular_function	calcium channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0015279	molecular_function	store-operated calcium channel activity
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0034703	cellular_component	cation channel complex
D	0051480	biological_process	regulation of cytosolic calcium ion concentration
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport
D	0070679	molecular_function	inositol 1,4,5 trisphosphate binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue PIO A 1001

Chain	Residue
A	VAL437
A	MET755
A	LYS762
D	ARG366
A	THR438
A	TYR440
A	THR441
A	LYS442
A	LEU503
A	LEU623
A	SER624
A	SER625

---

site_id	AC2
Number of Residues	13
Details	binding site for residue PCW A 1002

Chain	Residue
A	TYR440
A	TRP449
A	GLY450
A	ALA457
A	TRP461
A	ASP490
A	SER491
A	TYR500
A	PHE774
D	TYR87
D	TYR95
D	TRP125
D	VAL126

---

site_id	AC3
Number of Residues	9
Details	binding site for residue PIK A 1003

Chain	Residue
A	MET564
A	SER565
A	SER566
A	GLY567
A	TRP568
A	MET612
A	LYS635
A	ILE639
A	ARG761

---

site_id	AC4
Number of Residues	6
Details	binding site for residue PIO B 1001

Chain	Residue
A	ARG366
B	THR438
B	THR441
B	LYS442
B	LEU623
B	SER624

---

site_id	AC5
Number of Residues	13
Details	binding site for residue PCW B 1002

Chain	Residue
A	TYR85
A	TYR87
A	TYR95
A	TRP125
A	VAL126
A	TYR136
B	TYR440
B	TRP461
B	SER491
B	PRO494
B	TRP495
B	TYR500
B	LEU504

---

site_id	AC6
Number of Residues	12
Details	binding site for residue PIO C 1001

Chain	Residue
B	ARG366
C	VAL437
C	THR438
C	TYR440
C	THR441
C	LYS442
C	LEU503
C	LEU623
C	SER624
C	SER625
C	MET755
C	LYS762

---

site_id	AC7
Number of Residues	7
Details	binding site for residue PIK C 1003

Chain	Residue
C	MET564
C	SER565
C	SER566
C	GLY567
C	MET612
C	LYS635
C	ILE639

---

site_id	AC8
Number of Residues	6
Details	binding site for residue PIO D 1001

Chain	Residue
C	ARG366
D	THR438
D	THR441
D	LYS442
D	LEU623
D	SER624

---

site_id	AC9
Number of Residues	12
Details	binding site for residue PCW D 1002

Chain	Residue
C	TYR87
C	TYR95
C	TRP125
C	VAL126
C	TYR136
D	TYR440
D	TRP461
D	SER491
D	PRO494
D	TRP495
D	TYR500
D	LEU504

---

site_id	AD1
Number of Residues	18
Details	binding site for residue PIK B 1003

Chain	Residue
B	ASN603
B	LEU605
B	LEU606
B	ALA607
B	ALA608
B	MET612
B	PHE615
B	LYS635
B	ILE639
A	PHE727
B	MET564
B	SER565
B	GLY567
B	VAL570
B	MET571
B	LEU600
B	VAL601
B	VAL602

---

site_id	AD2
Number of Residues	16
Details	binding site for residue PCW C 1002

Chain	Residue
B	TYR87
B	TYR95
B	TRP125
B	VAL126
C	MET435
C	TYR440
C	TRP449
C	GLY450
C	ALA457
C	TRP461
C	ASP490
C	ARG492
C	PHE493
C	PRO494
C	TYR500
C	PHE774

---

site_id	AD3
Number of Residues	18
Details	binding site for residue PIK D 1003

Chain	Residue
C	PHE727
D	MET564
D	SER565
D	GLY567
D	VAL570
D	MET571
D	LEU600
D	VAL601
D	VAL602
D	ASN603
D	LEU605
D	LEU606
D	ALA607
D	ALA608
D	MET612
D	PHE615
D	LYS635
D	ILE639

---