6PW4

Cryo-EM Structure of Thermo-Sensitive TRP Channel TRP1 from the Alga Chlamydomonas reinhardtii in Detergent

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005262	molecular_function	calcium channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0015279	molecular_function	store-operated calcium channel activity
A	0016020	cellular_component	membrane
A	0034703	cellular_component	cation channel complex
A	0051480	biological_process	regulation of cytosolic calcium ion concentration
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0070679	molecular_function	inositol 1,4,5 trisphosphate binding
B	0005216	molecular_function	monoatomic ion channel activity
B	0005262	molecular_function	calcium channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0015279	molecular_function	store-operated calcium channel activity
B	0016020	cellular_component	membrane
B	0034703	cellular_component	cation channel complex
B	0051480	biological_process	regulation of cytosolic calcium ion concentration
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
B	0070679	molecular_function	inositol 1,4,5 trisphosphate binding
C	0005216	molecular_function	monoatomic ion channel activity
C	0005262	molecular_function	calcium channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0015279	molecular_function	store-operated calcium channel activity
C	0016020	cellular_component	membrane
C	0034703	cellular_component	cation channel complex
C	0051480	biological_process	regulation of cytosolic calcium ion concentration
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0070679	molecular_function	inositol 1,4,5 trisphosphate binding
D	0005216	molecular_function	monoatomic ion channel activity
D	0005262	molecular_function	calcium channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0015279	molecular_function	store-operated calcium channel activity
D	0016020	cellular_component	membrane
D	0034703	cellular_component	cation channel complex
D	0051480	biological_process	regulation of cytosolic calcium ion concentration
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport
D	0070679	molecular_function	inositol 1,4,5 trisphosphate binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue PIO A 1001

Chain	Residue
A	VAL437
A	THR438
A	THR441
A	LYS442
A	SER624
A	PHE758
A	LYS762

---

site_id	AC2
Number of Residues	14
Details	binding site for residue PCW A 1002

Chain	Residue
A	GLY450
A	PHE481
A	ASP490
A	SER491
A	ARG492
A	TRP495
A	TYR500
D	TYR85
D	TYR87
D	TYR95
D	TRP125
D	TYR136
A	TYR440
A	TRP449

---

site_id	AC3
Number of Residues	7
Details	binding site for residue CPL A 1003

Chain	Residue
A	TYR85
A	TYR87
A	TYR95
A	TRP125
A	TYR136
B	TYR440
B	TYR500

---

site_id	AC4
Number of Residues	6
Details	binding site for residue PIK B 1001

Chain	Residue
B	THR438
B	THR441
B	LYS442
B	PHE621
B	SER624
B	SER625

---

site_id	AC5
Number of Residues	6
Details	binding site for residue PIK D 1001

Chain	Residue
D	THR438
D	THR441
D	LYS442
D	PHE621
D	SER624
D	SER625

---

site_id	AC6
Number of Residues	16
Details	binding site for residue PIK B 1002

Chain	Residue
A	PHE727
B	SER565
B	GLY567
B	TRP568
B	VAL570
B	MET571
B	ASP604
B	ALA608
B	ALA610
B	LEU611
B	ALA613
B	TRP614
B	ARG616
B	LYS635
B	LEU638
B	ILE639

---

site_id	AC7
Number of Residues	14
Details	binding site for residue PIO C 1001

Chain	Residue
C	VAL437
C	THR438
C	THR441
C	LYS442
C	TRP502
C	SER624
C	PHE758
C	ARG759
C	TYR760
C	ARG761
C	ALA763
C	LYS764
C	LEU765
C	MET766

---

site_id	AC8
Number of Residues	19
Details	binding site for residue PCW C 1002

Chain	Residue
B	TYR85
B	TYR87
B	TYR95
B	TRP125
B	TYR136
C	TYR440
C	TRP449
C	GLY450
C	PHE481
C	ASP490
C	SER491
C	ARG492
C	PHE493
C	PRO494
C	HIS496
C	VAL497
C	TYR500
C	ARG501
C	PHE774

---

site_id	AC9
Number of Residues	13
Details	binding site for residue CPL C 1003

Chain	Residue
C	TYR136
D	TYR440
D	TYR500
C	THR80
C	ASP82
C	TYR85
C	HIS86
C	SER88
C	LEU91
C	TYR92
C	TYR95
C	CYS124
C	TRP125

---

site_id	AD1
Number of Residues	16
Details	binding site for residue PIK D 1002

Chain	Residue
C	PHE727
D	SER565
D	GLY567
D	TRP568
D	VAL570
D	MET571
D	ASP604
D	ALA608
D	ALA610
D	LEU611
D	ALA613
D	TRP614
D	ARG616
D	LYS635
D	LEU638
D	ILE639

---