6PW4
Cryo-EM Structure of Thermo-Sensitive TRP Channel TRP1 from the Alga Chlamydomonas reinhardtii in Detergent
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0015279 | molecular_function | store-operated calcium channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0034703 | cellular_component | cation channel complex |
| A | 0051480 | biological_process | regulation of cytosolic calcium ion concentration |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0070679 | molecular_function | inositol 1,4,5 trisphosphate binding |
| B | 0005262 | molecular_function | calcium channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0015279 | molecular_function | store-operated calcium channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0034703 | cellular_component | cation channel complex |
| B | 0051480 | biological_process | regulation of cytosolic calcium ion concentration |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0070679 | molecular_function | inositol 1,4,5 trisphosphate binding |
| C | 0005262 | molecular_function | calcium channel activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0015279 | molecular_function | store-operated calcium channel activity |
| C | 0016020 | cellular_component | membrane |
| C | 0034703 | cellular_component | cation channel complex |
| C | 0051480 | biological_process | regulation of cytosolic calcium ion concentration |
| C | 0070588 | biological_process | calcium ion transmembrane transport |
| C | 0070679 | molecular_function | inositol 1,4,5 trisphosphate binding |
| D | 0005262 | molecular_function | calcium channel activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0015279 | molecular_function | store-operated calcium channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0034703 | cellular_component | cation channel complex |
| D | 0051480 | biological_process | regulation of cytosolic calcium ion concentration |
| D | 0070588 | biological_process | calcium ion transmembrane transport |
| D | 0070679 | molecular_function | inositol 1,4,5 trisphosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue PIO A 1001 |
| Chain | Residue |
| A | VAL437 |
| A | THR438 |
| A | THR441 |
| A | LYS442 |
| A | SER624 |
| A | PHE758 |
| A | LYS762 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue PCW A 1002 |
| Chain | Residue |
| A | GLY450 |
| A | PHE481 |
| A | ASP490 |
| A | SER491 |
| A | ARG492 |
| A | TRP495 |
| A | TYR500 |
| D | TYR85 |
| D | TYR87 |
| D | TYR95 |
| D | TRP125 |
| D | TYR136 |
| A | TYR440 |
| A | TRP449 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue CPL A 1003 |
| Chain | Residue |
| A | TYR85 |
| A | TYR87 |
| A | TYR95 |
| A | TRP125 |
| A | TYR136 |
| B | TYR440 |
| B | TYR500 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue PIK B 1001 |
| Chain | Residue |
| B | THR438 |
| B | THR441 |
| B | LYS442 |
| B | PHE621 |
| B | SER624 |
| B | SER625 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue PIK D 1001 |
| Chain | Residue |
| D | THR438 |
| D | THR441 |
| D | LYS442 |
| D | PHE621 |
| D | SER624 |
| D | SER625 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | binding site for residue PIK B 1002 |
| Chain | Residue |
| A | PHE727 |
| B | SER565 |
| B | GLY567 |
| B | TRP568 |
| B | VAL570 |
| B | MET571 |
| B | ASP604 |
| B | ALA608 |
| B | ALA610 |
| B | LEU611 |
| B | ALA613 |
| B | TRP614 |
| B | ARG616 |
| B | LYS635 |
| B | LEU638 |
| B | ILE639 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | binding site for residue PIO C 1001 |
| Chain | Residue |
| C | VAL437 |
| C | THR438 |
| C | THR441 |
| C | LYS442 |
| C | TRP502 |
| C | SER624 |
| C | PHE758 |
| C | ARG759 |
| C | TYR760 |
| C | ARG761 |
| C | ALA763 |
| C | LYS764 |
| C | LEU765 |
| C | MET766 |
| site_id | AC8 |
| Number of Residues | 19 |
| Details | binding site for residue PCW C 1002 |
| Chain | Residue |
| B | TYR85 |
| B | TYR87 |
| B | TYR95 |
| B | TRP125 |
| B | TYR136 |
| C | TYR440 |
| C | TRP449 |
| C | GLY450 |
| C | PHE481 |
| C | ASP490 |
| C | SER491 |
| C | ARG492 |
| C | PHE493 |
| C | PRO494 |
| C | HIS496 |
| C | VAL497 |
| C | TYR500 |
| C | ARG501 |
| C | PHE774 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | binding site for residue CPL C 1003 |
| Chain | Residue |
| C | TYR136 |
| D | TYR440 |
| D | TYR500 |
| C | THR80 |
| C | ASP82 |
| C | TYR85 |
| C | HIS86 |
| C | SER88 |
| C | LEU91 |
| C | TYR92 |
| C | TYR95 |
| C | CYS124 |
| C | TRP125 |
| site_id | AD1 |
| Number of Residues | 16 |
| Details | binding site for residue PIK D 1002 |
| Chain | Residue |
| C | PHE727 |
| D | SER565 |
| D | GLY567 |
| D | TRP568 |
| D | VAL570 |
| D | MET571 |
| D | ASP604 |
| D | ALA608 |
| D | ALA610 |
| D | LEU611 |
| D | ALA613 |
| D | TRP614 |
| D | ARG616 |
| D | LYS635 |
| D | LEU638 |
| D | ILE639 |
