6PUX
Homoserine transacetylase MetX from Mycobacterium tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004414 | molecular_function | homoserine O-acetyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0009092 | biological_process | homoserine metabolic process |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004414 | molecular_function | homoserine O-acetyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0009092 | biological_process | homoserine metabolic process |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 401 |
| Chain | Residue |
| A | GLY297 |
| A | ARG298 |
| A | GLY299 |
| A | GLY300 |
| A | HOH502 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | ARG227 |
| A | GLN269 |
| A | LYS272 |
| A | ARG276 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 403 |
| Chain | Residue |
| A | LYS202 |
| A | TRP207 |
| A | HOH591 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 404 |
| Chain | Residue |
| A | ASP293 |
| A | HOH502 |
| A | HOH575 |
| A | HOH705 |
| A | HOH708 |
| A | HOH742 |
| B | HOH658 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 405 |
| Chain | Residue |
| A | ALA332 |
| A | ASP333 |
| A | LEU335 |
| A | CYS338 |
| A | HOH723 |
| A | HOH725 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 406 |
| Chain | Residue |
| A | SER130 |
| A | ILE131 |
| A | ALA288 |
| A | SER291 |
| A | HIS292 |
| A | HOH662 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 407 |
| Chain | Residue |
| A | VAL301 |
| A | SER302 |
| A | HOH609 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 408 |
| Chain | Residue |
| A | THR61 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 401 |
| Chain | Residue |
| A | ASP241 |
| B | ARG185 |
| B | ARG326 |
| B | LEU327 |
| B | GLU330 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 402 |
| Chain | Residue |
| A | ARG50 |
| B | GLN329 |
| B | GLY340 |
| B | LEU341 |
| B | HOH514 |
| B | HOH517 |
| B | HOH627 |
| B | HOH636 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 403 |
| Chain | Residue |
| B | ARG117 |
| B | GLY297 |
| B | HOH518 |
| B | HOH537 |
| B | HOH540 |
| B | HOH649 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 404 |
| Chain | Residue |
| A | HOH560 |
| B | ARG185 |
| B | GLY300 |
| B | VAL301 |
| B | HOH513 |
| B | HOH565 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 405 |
| Chain | Residue |
| B | LYS202 |
| B | TRP207 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 406 |
| Chain | Residue |
| B | ARG227 |
| B | LYS272 |
| B | ARG276 |
| B | HOH644 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 407 |
| Chain | Residue |
| B | ARG42 |
| B | LYS45 |
| B | LEU46 |
| B | HOH532 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 408 |
| Chain | Residue |
| B | SER130 |
| B | ILE131 |
| B | ALA288 |
| B | SER291 |
| B | HIS292 |
| B | HOH690 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 409 |
| Chain | Residue |
| B | ALA332 |
| B | ASP333 |
| B | LEU335 |
| B | CYS338 |
| B | HOH714 |
| B | HOH734 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 410 |
| Chain | Residue |
| A | HOH560 |
| B | ASP293 |
| B | HOH540 |
| B | HOH565 |
| B | HOH746 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 411 |
| Chain | Residue |
| B | ALA31 |
| B | VAL32 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_00296 |
| Chain | Residue | Details |
| A | SER157 | |
| B | SER157 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00296 |
| Chain | Residue | Details |
| A | ASP320 | |
| A | HIS350 | |
| B | ASP320 | |
| B | HIS350 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00296 |
| Chain | Residue | Details |
| A | ARG227 | |
| A | ASP351 | |
| B | ARG227 | |
| B | ASP351 |
