6PTO

Structure of Ctf4 trimer in complex with three CMG helicases

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0000166	molecular_function	nucleotide binding
2	0000727	biological_process	double-strand break repair via break-induced replication
2	0003677	molecular_function	DNA binding
2	0003678	molecular_function	DNA helicase activity
2	0003682	molecular_function	chromatin binding
2	0003688	molecular_function	DNA replication origin binding
2	0003697	molecular_function	single-stranded DNA binding
2	0004386	molecular_function	helicase activity
2	0005515	molecular_function	protein binding
2	0005524	molecular_function	ATP binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005656	cellular_component	nuclear pre-replicative complex
2	0005737	cellular_component	cytoplasm
2	0006260	biological_process	DNA replication
2	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
2	0006270	biological_process	DNA replication initiation
2	0006271	biological_process	DNA strand elongation involved in DNA replication
2	0006279	biological_process	premeiotic DNA replication
2	0006974	biological_process	DNA damage response
2	0008270	molecular_function	zinc ion binding
2	0016787	molecular_function	hydrolase activity
2	0016887	molecular_function	ATP hydrolysis activity
2	0017116	molecular_function	single-stranded DNA helicase activity
2	0031261	cellular_component	DNA replication preinitiation complex
2	0042555	cellular_component	MCM complex
2	0043138	molecular_function	3'-5' DNA helicase activity
2	0043596	cellular_component	nuclear replication fork
2	0046872	molecular_function	metal ion binding
2	0071162	cellular_component	CMG complex
2	1902975	biological_process	mitotic DNA replication initiation
3	0000166	molecular_function	nucleotide binding
3	0000727	biological_process	double-strand break repair via break-induced replication
3	0000781	cellular_component	chromosome, telomeric region
3	0003677	molecular_function	DNA binding
3	0003678	molecular_function	DNA helicase activity
3	0003682	molecular_function	chromatin binding
3	0003688	molecular_function	DNA replication origin binding
3	0003697	molecular_function	single-stranded DNA binding
3	0004386	molecular_function	helicase activity
3	0005515	molecular_function	protein binding
3	0005524	molecular_function	ATP binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005656	cellular_component	nuclear pre-replicative complex
3	0005737	cellular_component	cytoplasm
3	0006260	biological_process	DNA replication
3	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
3	0006270	biological_process	DNA replication initiation
3	0006271	biological_process	DNA strand elongation involved in DNA replication
3	0006279	biological_process	premeiotic DNA replication
3	0016787	molecular_function	hydrolase activity
3	0016887	molecular_function	ATP hydrolysis activity
3	0017116	molecular_function	single-stranded DNA helicase activity
3	0030466	biological_process	silent mating-type cassette heterochromatin formation
3	0031261	cellular_component	DNA replication preinitiation complex
3	0031509	biological_process	subtelomeric heterochromatin formation
3	0042555	cellular_component	MCM complex
3	0043596	cellular_component	nuclear replication fork
3	0071162	cellular_component	CMG complex
3	1902975	biological_process	mitotic DNA replication initiation
3	1904931	molecular_function	MCM complex binding
4	0000166	molecular_function	nucleotide binding
4	0000727	biological_process	double-strand break repair via break-induced replication
4	0003677	molecular_function	DNA binding
4	0003678	molecular_function	DNA helicase activity
4	0003688	molecular_function	DNA replication origin binding
4	0003697	molecular_function	single-stranded DNA binding
4	0004386	molecular_function	helicase activity
4	0005515	molecular_function	protein binding
4	0005524	molecular_function	ATP binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005656	cellular_component	nuclear pre-replicative complex
4	0005737	cellular_component	cytoplasm
4	0006260	biological_process	DNA replication
4	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
4	0006270	biological_process	DNA replication initiation
4	0006271	biological_process	DNA strand elongation involved in DNA replication
4	0006279	biological_process	premeiotic DNA replication
4	0008270	molecular_function	zinc ion binding
4	0009378	molecular_function	four-way junction helicase activity
4	0016787	molecular_function	hydrolase activity
4	0016887	molecular_function	ATP hydrolysis activity
4	0017116	molecular_function	single-stranded DNA helicase activity
4	0031261	cellular_component	DNA replication preinitiation complex
4	0033260	biological_process	nuclear DNA replication
4	0042555	cellular_component	MCM complex
4	0043138	molecular_function	3'-5' DNA helicase activity
4	0043596	cellular_component	nuclear replication fork
4	0071162	cellular_component	CMG complex
4	0097373	cellular_component	MCM core complex
4	1902975	biological_process	mitotic DNA replication initiation
5	0000166	molecular_function	nucleotide binding
5	0000727	biological_process	double-strand break repair via break-induced replication
5	0000781	cellular_component	chromosome, telomeric region
5	0003677	molecular_function	DNA binding
5	0003678	molecular_function	DNA helicase activity
5	0003682	molecular_function	chromatin binding
5	0003688	molecular_function	DNA replication origin binding
5	0003697	molecular_function	single-stranded DNA binding
5	0004386	molecular_function	helicase activity
5	0005515	molecular_function	protein binding
5	0005524	molecular_function	ATP binding
5	0005634	cellular_component	nucleus
5	0005654	cellular_component	nucleoplasm
5	0005656	cellular_component	nuclear pre-replicative complex
5	0005737	cellular_component	cytoplasm
5	0006260	biological_process	DNA replication
5	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
5	0006270	biological_process	DNA replication initiation
5	0006279	biological_process	premeiotic DNA replication
5	0006368	biological_process	transcription elongation by RNA polymerase II
5	0008270	molecular_function	zinc ion binding
5	0016787	molecular_function	hydrolase activity
5	0016887	molecular_function	ATP hydrolysis activity
5	0017116	molecular_function	single-stranded DNA helicase activity
5	0030174	biological_process	regulation of DNA-templated DNA replication initiation
5	0031261	cellular_component	DNA replication preinitiation complex
5	0031507	biological_process	heterochromatin formation
5	0031509	biological_process	subtelomeric heterochromatin formation
5	0033260	biological_process	nuclear DNA replication
5	0042555	cellular_component	MCM complex
5	0043138	molecular_function	3'-5' DNA helicase activity
5	0043596	cellular_component	nuclear replication fork
5	0071162	cellular_component	CMG complex
6	0000166	molecular_function	nucleotide binding
6	0000727	biological_process	double-strand break repair via break-induced replication
6	0003677	molecular_function	DNA binding
6	0003678	molecular_function	DNA helicase activity
6	0003688	molecular_function	DNA replication origin binding
6	0003697	molecular_function	single-stranded DNA binding
6	0004386	molecular_function	helicase activity
6	0005515	molecular_function	protein binding
6	0005524	molecular_function	ATP binding
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0005656	cellular_component	nuclear pre-replicative complex
6	0005737	cellular_component	cytoplasm
6	0005777	cellular_component	peroxisome
6	0006260	biological_process	DNA replication
6	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
6	0006270	biological_process	DNA replication initiation
6	0006271	biological_process	DNA strand elongation involved in DNA replication
6	0006279	biological_process	premeiotic DNA replication
6	0008270	molecular_function	zinc ion binding
6	0009378	molecular_function	four-way junction helicase activity
6	0016787	molecular_function	hydrolase activity
6	0016887	molecular_function	ATP hydrolysis activity
6	0017116	molecular_function	single-stranded DNA helicase activity
6	0031261	cellular_component	DNA replication preinitiation complex
6	0042555	cellular_component	MCM complex
6	0043138	molecular_function	3'-5' DNA helicase activity
6	0043596	cellular_component	nuclear replication fork
6	0071162	cellular_component	CMG complex
6	0097373	cellular_component	MCM core complex
6	1902969	biological_process	mitotic DNA replication
6	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
7	0000166	molecular_function	nucleotide binding
7	0000727	biological_process	double-strand break repair via break-induced replication
7	0000781	cellular_component	chromosome, telomeric region
7	0003677	molecular_function	DNA binding
7	0003678	molecular_function	DNA helicase activity
7	0003682	molecular_function	chromatin binding
7	0003688	molecular_function	DNA replication origin binding
7	0003697	molecular_function	single-stranded DNA binding
7	0004386	molecular_function	helicase activity
7	0005515	molecular_function	protein binding
7	0005524	molecular_function	ATP binding
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005656	cellular_component	nuclear pre-replicative complex
7	0005737	cellular_component	cytoplasm
7	0006260	biological_process	DNA replication
7	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
7	0006270	biological_process	DNA replication initiation
7	0006271	biological_process	DNA strand elongation involved in DNA replication
7	0006279	biological_process	premeiotic DNA replication
7	0008270	molecular_function	zinc ion binding
7	0009378	molecular_function	four-way junction helicase activity
7	0016787	molecular_function	hydrolase activity
7	0016887	molecular_function	ATP hydrolysis activity
7	0017116	molecular_function	single-stranded DNA helicase activity
7	0030466	biological_process	silent mating-type cassette heterochromatin formation
7	0031261	cellular_component	DNA replication preinitiation complex
7	0031509	biological_process	subtelomeric heterochromatin formation
7	0033260	biological_process	nuclear DNA replication
7	0042555	cellular_component	MCM complex
7	0043138	molecular_function	3'-5' DNA helicase activity
7	0043596	cellular_component	nuclear replication fork
7	0071162	cellular_component	CMG complex
7	0097373	cellular_component	MCM core complex
7	1904931	molecular_function	MCM complex binding
A	0000727	biological_process	double-strand break repair via break-induced replication
A	0000811	cellular_component	GINS complex
A	0003674	molecular_function	molecular_function
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0031261	cellular_component	DNA replication preinitiation complex
A	0043596	cellular_component	nuclear replication fork
A	0071162	cellular_component	CMG complex
A	1902983	biological_process	DNA strand elongation involved in mitotic DNA replication
B	0000228	cellular_component	nuclear chromosome
B	0000727	biological_process	double-strand break repair via break-induced replication
B	0000811	cellular_component	GINS complex
B	0003674	molecular_function	molecular_function
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0006260	biological_process	DNA replication
B	0006261	biological_process	DNA-templated DNA replication
B	0031261	cellular_component	DNA replication preinitiation complex
B	0043596	cellular_component	nuclear replication fork
B	0071162	cellular_component	CMG complex
C	0000727	biological_process	double-strand break repair via break-induced replication
C	0000811	cellular_component	GINS complex
C	0003674	molecular_function	molecular_function
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0006260	biological_process	DNA replication
C	0006261	biological_process	DNA-templated DNA replication
C	0006270	biological_process	DNA replication initiation
C	0031261	cellular_component	DNA replication preinitiation complex
C	0043596	cellular_component	nuclear replication fork
C	0071162	cellular_component	CMG complex
D	0000727	biological_process	double-strand break repair via break-induced replication
D	0000811	cellular_component	GINS complex
D	0003674	molecular_function	molecular_function
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0006260	biological_process	DNA replication
D	0006261	biological_process	DNA-templated DNA replication
D	0031261	cellular_component	DNA replication preinitiation complex
D	0043596	cellular_component	nuclear replication fork
D	0071162	cellular_component	CMG complex
E	0000727	biological_process	double-strand break repair via break-induced replication
E	0003682	molecular_function	chromatin binding
E	0003688	molecular_function	DNA replication origin binding
E	0003697	molecular_function	single-stranded DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0006260	biological_process	DNA replication
E	0006270	biological_process	DNA replication initiation
E	0031261	cellular_component	DNA replication preinitiation complex
E	0043596	cellular_component	nuclear replication fork
E	0071162	cellular_component	CMG complex
E	1902977	biological_process	mitotic DNA replication preinitiation complex assembly
F	0000166	molecular_function	nucleotide binding
F	0000727	biological_process	double-strand break repair via break-induced replication
F	0003677	molecular_function	DNA binding
F	0003678	molecular_function	DNA helicase activity
F	0003682	molecular_function	chromatin binding
F	0003688	molecular_function	DNA replication origin binding
F	0003697	molecular_function	single-stranded DNA binding
F	0004386	molecular_function	helicase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005656	cellular_component	nuclear pre-replicative complex
F	0005737	cellular_component	cytoplasm
F	0006260	biological_process	DNA replication
F	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
F	0006270	biological_process	DNA replication initiation
F	0006271	biological_process	DNA strand elongation involved in DNA replication
F	0006279	biological_process	premeiotic DNA replication
F	0006974	biological_process	DNA damage response
F	0008270	molecular_function	zinc ion binding
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0017116	molecular_function	single-stranded DNA helicase activity
F	0031261	cellular_component	DNA replication preinitiation complex
F	0042555	cellular_component	MCM complex
F	0043138	molecular_function	3'-5' DNA helicase activity
F	0043596	cellular_component	nuclear replication fork
F	0046872	molecular_function	metal ion binding
F	0071162	cellular_component	CMG complex
F	1902975	biological_process	mitotic DNA replication initiation
G	0000166	molecular_function	nucleotide binding
G	0000727	biological_process	double-strand break repair via break-induced replication
G	0000781	cellular_component	chromosome, telomeric region
G	0003677	molecular_function	DNA binding
G	0003678	molecular_function	DNA helicase activity
G	0003682	molecular_function	chromatin binding
G	0003688	molecular_function	DNA replication origin binding
G	0003697	molecular_function	single-stranded DNA binding
G	0004386	molecular_function	helicase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005656	cellular_component	nuclear pre-replicative complex
G	0005737	cellular_component	cytoplasm
G	0006260	biological_process	DNA replication
G	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
G	0006270	biological_process	DNA replication initiation
G	0006271	biological_process	DNA strand elongation involved in DNA replication
G	0006279	biological_process	premeiotic DNA replication
G	0016787	molecular_function	hydrolase activity
G	0016887	molecular_function	ATP hydrolysis activity
G	0017116	molecular_function	single-stranded DNA helicase activity
G	0030466	biological_process	silent mating-type cassette heterochromatin formation
G	0031261	cellular_component	DNA replication preinitiation complex
G	0031509	biological_process	subtelomeric heterochromatin formation
G	0042555	cellular_component	MCM complex
G	0043596	cellular_component	nuclear replication fork
G	0071162	cellular_component	CMG complex
G	1902975	biological_process	mitotic DNA replication initiation
G	1904931	molecular_function	MCM complex binding
H	0000166	molecular_function	nucleotide binding
H	0000727	biological_process	double-strand break repair via break-induced replication
H	0003677	molecular_function	DNA binding
H	0003678	molecular_function	DNA helicase activity
H	0003688	molecular_function	DNA replication origin binding
H	0003697	molecular_function	single-stranded DNA binding
H	0004386	molecular_function	helicase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005656	cellular_component	nuclear pre-replicative complex
H	0005737	cellular_component	cytoplasm
H	0006260	biological_process	DNA replication
H	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
H	0006270	biological_process	DNA replication initiation
H	0006271	biological_process	DNA strand elongation involved in DNA replication
H	0006279	biological_process	premeiotic DNA replication
H	0008270	molecular_function	zinc ion binding
H	0009378	molecular_function	four-way junction helicase activity
H	0016787	molecular_function	hydrolase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0017116	molecular_function	single-stranded DNA helicase activity
H	0031261	cellular_component	DNA replication preinitiation complex
H	0033260	biological_process	nuclear DNA replication
H	0042555	cellular_component	MCM complex
H	0043138	molecular_function	3'-5' DNA helicase activity
H	0043596	cellular_component	nuclear replication fork
H	0071162	cellular_component	CMG complex
H	0097373	cellular_component	MCM core complex
H	1902975	biological_process	mitotic DNA replication initiation
I	0000166	molecular_function	nucleotide binding
I	0000727	biological_process	double-strand break repair via break-induced replication
I	0000781	cellular_component	chromosome, telomeric region
I	0003677	molecular_function	DNA binding
I	0003678	molecular_function	DNA helicase activity
I	0003682	molecular_function	chromatin binding
I	0003688	molecular_function	DNA replication origin binding
I	0003697	molecular_function	single-stranded DNA binding
I	0004386	molecular_function	helicase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005656	cellular_component	nuclear pre-replicative complex
I	0005737	cellular_component	cytoplasm
I	0006260	biological_process	DNA replication
I	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
I	0006270	biological_process	DNA replication initiation
I	0006279	biological_process	premeiotic DNA replication
I	0006368	biological_process	transcription elongation by RNA polymerase II
I	0008270	molecular_function	zinc ion binding
I	0016787	molecular_function	hydrolase activity
I	0016887	molecular_function	ATP hydrolysis activity
I	0017116	molecular_function	single-stranded DNA helicase activity
I	0030174	biological_process	regulation of DNA-templated DNA replication initiation
I	0031261	cellular_component	DNA replication preinitiation complex
I	0031507	biological_process	heterochromatin formation
I	0031509	biological_process	subtelomeric heterochromatin formation
I	0033260	biological_process	nuclear DNA replication
I	0042555	cellular_component	MCM complex
I	0043138	molecular_function	3'-5' DNA helicase activity
I	0043596	cellular_component	nuclear replication fork
I	0071162	cellular_component	CMG complex
J	0000166	molecular_function	nucleotide binding
J	0000727	biological_process	double-strand break repair via break-induced replication
J	0003677	molecular_function	DNA binding
J	0003678	molecular_function	DNA helicase activity
J	0003688	molecular_function	DNA replication origin binding
J	0003697	molecular_function	single-stranded DNA binding
J	0004386	molecular_function	helicase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005656	cellular_component	nuclear pre-replicative complex
J	0005737	cellular_component	cytoplasm
J	0005777	cellular_component	peroxisome
J	0006260	biological_process	DNA replication
J	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
J	0006270	biological_process	DNA replication initiation
J	0006271	biological_process	DNA strand elongation involved in DNA replication
J	0006279	biological_process	premeiotic DNA replication
J	0008270	molecular_function	zinc ion binding
J	0009378	molecular_function	four-way junction helicase activity
J	0016787	molecular_function	hydrolase activity
J	0016887	molecular_function	ATP hydrolysis activity
J	0017116	molecular_function	single-stranded DNA helicase activity
J	0031261	cellular_component	DNA replication preinitiation complex
J	0042555	cellular_component	MCM complex
J	0043138	molecular_function	3'-5' DNA helicase activity
J	0043596	cellular_component	nuclear replication fork
J	0071162	cellular_component	CMG complex
J	0097373	cellular_component	MCM core complex
J	1902969	biological_process	mitotic DNA replication
J	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
K	0000166	molecular_function	nucleotide binding
K	0000727	biological_process	double-strand break repair via break-induced replication
K	0000781	cellular_component	chromosome, telomeric region
K	0003677	molecular_function	DNA binding
K	0003678	molecular_function	DNA helicase activity
K	0003682	molecular_function	chromatin binding
K	0003688	molecular_function	DNA replication origin binding
K	0003697	molecular_function	single-stranded DNA binding
K	0004386	molecular_function	helicase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005656	cellular_component	nuclear pre-replicative complex
K	0005737	cellular_component	cytoplasm
K	0006260	biological_process	DNA replication
K	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
K	0006270	biological_process	DNA replication initiation
K	0006271	biological_process	DNA strand elongation involved in DNA replication
K	0006279	biological_process	premeiotic DNA replication
K	0008270	molecular_function	zinc ion binding
K	0009378	molecular_function	four-way junction helicase activity
K	0016787	molecular_function	hydrolase activity
K	0016887	molecular_function	ATP hydrolysis activity
K	0017116	molecular_function	single-stranded DNA helicase activity
K	0030466	biological_process	silent mating-type cassette heterochromatin formation
K	0031261	cellular_component	DNA replication preinitiation complex
K	0031509	biological_process	subtelomeric heterochromatin formation
K	0033260	biological_process	nuclear DNA replication
K	0042555	cellular_component	MCM complex
K	0043138	molecular_function	3'-5' DNA helicase activity
K	0043596	cellular_component	nuclear replication fork
K	0071162	cellular_component	CMG complex
K	0097373	cellular_component	MCM core complex
K	1904931	molecular_function	MCM complex binding
X	0000228	cellular_component	nuclear chromosome
X	0000278	biological_process	mitotic cell cycle
X	0000727	biological_process	double-strand break repair via break-induced replication
X	0003682	molecular_function	chromatin binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0006260	biological_process	DNA replication
X	0006261	biological_process	DNA-templated DNA replication
X	0006270	biological_process	DNA replication initiation
X	0006281	biological_process	DNA repair
X	0006334	biological_process	nucleosome assembly
X	0007064	biological_process	mitotic sister chromatid cohesion
X	0034085	biological_process	establishment of sister chromatid cohesion
X	0042802	molecular_function	identical protein binding
X	0043596	cellular_component	nuclear replication fork
Y	0000228	cellular_component	nuclear chromosome
Y	0000278	biological_process	mitotic cell cycle
Y	0000727	biological_process	double-strand break repair via break-induced replication
Y	0003682	molecular_function	chromatin binding
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0006260	biological_process	DNA replication
Y	0006261	biological_process	DNA-templated DNA replication
Y	0006270	biological_process	DNA replication initiation
Y	0006281	biological_process	DNA repair
Y	0006334	biological_process	nucleosome assembly
Y	0007064	biological_process	mitotic sister chromatid cohesion
Y	0034085	biological_process	establishment of sister chromatid cohesion
Y	0042802	molecular_function	identical protein binding
Y	0043596	cellular_component	nuclear replication fork
Z	0000228	cellular_component	nuclear chromosome
Z	0000278	biological_process	mitotic cell cycle
Z	0000727	biological_process	double-strand break repair via break-induced replication
Z	0003682	molecular_function	chromatin binding
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0006260	biological_process	DNA replication
Z	0006261	biological_process	DNA-templated DNA replication
Z	0006270	biological_process	DNA replication initiation
Z	0006281	biological_process	DNA repair
Z	0006334	biological_process	nucleosome assembly
Z	0007064	biological_process	mitotic sister chromatid cohesion
Z	0034085	biological_process	establishment of sister chromatid cohesion
Z	0042802	molecular_function	identical protein binding
Z	0043596	cellular_component	nuclear replication fork
a	0000727	biological_process	double-strand break repair via break-induced replication
a	0000811	cellular_component	GINS complex
a	0003674	molecular_function	molecular_function
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0006260	biological_process	DNA replication
a	0006261	biological_process	DNA-templated DNA replication
a	0031261	cellular_component	DNA replication preinitiation complex
a	0043596	cellular_component	nuclear replication fork
a	0071162	cellular_component	CMG complex
a	1902983	biological_process	DNA strand elongation involved in mitotic DNA replication
b	0000228	cellular_component	nuclear chromosome
b	0000727	biological_process	double-strand break repair via break-induced replication
b	0000811	cellular_component	GINS complex
b	0003674	molecular_function	molecular_function
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0006260	biological_process	DNA replication
b	0006261	biological_process	DNA-templated DNA replication
b	0031261	cellular_component	DNA replication preinitiation complex
b	0043596	cellular_component	nuclear replication fork
b	0071162	cellular_component	CMG complex
c	0000727	biological_process	double-strand break repair via break-induced replication
c	0000811	cellular_component	GINS complex
c	0003674	molecular_function	molecular_function
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0006260	biological_process	DNA replication
c	0006261	biological_process	DNA-templated DNA replication
c	0006270	biological_process	DNA replication initiation
c	0031261	cellular_component	DNA replication preinitiation complex
c	0043596	cellular_component	nuclear replication fork
c	0071162	cellular_component	CMG complex
d	0000727	biological_process	double-strand break repair via break-induced replication
d	0000811	cellular_component	GINS complex
d	0003674	molecular_function	molecular_function
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0006260	biological_process	DNA replication
d	0006261	biological_process	DNA-templated DNA replication
d	0031261	cellular_component	DNA replication preinitiation complex
d	0043596	cellular_component	nuclear replication fork
d	0071162	cellular_component	CMG complex
e	0000727	biological_process	double-strand break repair via break-induced replication
e	0003682	molecular_function	chromatin binding
e	0003688	molecular_function	DNA replication origin binding
e	0003697	molecular_function	single-stranded DNA binding
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0006260	biological_process	DNA replication
e	0006270	biological_process	DNA replication initiation
e	0031261	cellular_component	DNA replication preinitiation complex
e	0043596	cellular_component	nuclear replication fork
e	0071162	cellular_component	CMG complex
e	1902977	biological_process	mitotic DNA replication preinitiation complex assembly
h	0000166	molecular_function	nucleotide binding
h	0000727	biological_process	double-strand break repair via break-induced replication
h	0003677	molecular_function	DNA binding
h	0003678	molecular_function	DNA helicase activity
h	0003682	molecular_function	chromatin binding
h	0003688	molecular_function	DNA replication origin binding
h	0003697	molecular_function	single-stranded DNA binding
h	0004386	molecular_function	helicase activity
h	0005515	molecular_function	protein binding
h	0005524	molecular_function	ATP binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005656	cellular_component	nuclear pre-replicative complex
h	0005737	cellular_component	cytoplasm
h	0006260	biological_process	DNA replication
h	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
h	0006270	biological_process	DNA replication initiation
h	0006271	biological_process	DNA strand elongation involved in DNA replication
h	0006279	biological_process	premeiotic DNA replication
h	0006974	biological_process	DNA damage response
h	0008270	molecular_function	zinc ion binding
h	0016787	molecular_function	hydrolase activity
h	0016887	molecular_function	ATP hydrolysis activity
h	0017116	molecular_function	single-stranded DNA helicase activity
h	0031261	cellular_component	DNA replication preinitiation complex
h	0042555	cellular_component	MCM complex
h	0043138	molecular_function	3'-5' DNA helicase activity
h	0043596	cellular_component	nuclear replication fork
h	0046872	molecular_function	metal ion binding
h	0071162	cellular_component	CMG complex
h	1902975	biological_process	mitotic DNA replication initiation
i	0000166	molecular_function	nucleotide binding
i	0000727	biological_process	double-strand break repair via break-induced replication
i	0000781	cellular_component	chromosome, telomeric region
i	0003677	molecular_function	DNA binding
i	0003678	molecular_function	DNA helicase activity
i	0003682	molecular_function	chromatin binding
i	0003688	molecular_function	DNA replication origin binding
i	0003697	molecular_function	single-stranded DNA binding
i	0004386	molecular_function	helicase activity
i	0005515	molecular_function	protein binding
i	0005524	molecular_function	ATP binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005656	cellular_component	nuclear pre-replicative complex
i	0005737	cellular_component	cytoplasm
i	0006260	biological_process	DNA replication
i	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
i	0006270	biological_process	DNA replication initiation
i	0006271	biological_process	DNA strand elongation involved in DNA replication
i	0006279	biological_process	premeiotic DNA replication
i	0016787	molecular_function	hydrolase activity
i	0016887	molecular_function	ATP hydrolysis activity
i	0017116	molecular_function	single-stranded DNA helicase activity
i	0030466	biological_process	silent mating-type cassette heterochromatin formation
i	0031261	cellular_component	DNA replication preinitiation complex
i	0031509	biological_process	subtelomeric heterochromatin formation
i	0042555	cellular_component	MCM complex
i	0043596	cellular_component	nuclear replication fork
i	0071162	cellular_component	CMG complex
i	1902975	biological_process	mitotic DNA replication initiation
i	1904931	molecular_function	MCM complex binding
j	0000166	molecular_function	nucleotide binding
j	0000727	biological_process	double-strand break repair via break-induced replication
j	0003677	molecular_function	DNA binding
j	0003678	molecular_function	DNA helicase activity
j	0003688	molecular_function	DNA replication origin binding
j	0003697	molecular_function	single-stranded DNA binding
j	0004386	molecular_function	helicase activity
j	0005515	molecular_function	protein binding
j	0005524	molecular_function	ATP binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005656	cellular_component	nuclear pre-replicative complex
j	0005737	cellular_component	cytoplasm
j	0006260	biological_process	DNA replication
j	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
j	0006270	biological_process	DNA replication initiation
j	0006271	biological_process	DNA strand elongation involved in DNA replication
j	0006279	biological_process	premeiotic DNA replication
j	0008270	molecular_function	zinc ion binding
j	0009378	molecular_function	four-way junction helicase activity
j	0016787	molecular_function	hydrolase activity
j	0016887	molecular_function	ATP hydrolysis activity
j	0017116	molecular_function	single-stranded DNA helicase activity
j	0031261	cellular_component	DNA replication preinitiation complex
j	0033260	biological_process	nuclear DNA replication
j	0042555	cellular_component	MCM complex
j	0043138	molecular_function	3'-5' DNA helicase activity
j	0043596	cellular_component	nuclear replication fork
j	0071162	cellular_component	CMG complex
j	0097373	cellular_component	MCM core complex
j	1902975	biological_process	mitotic DNA replication initiation
k	0000166	molecular_function	nucleotide binding
k	0000727	biological_process	double-strand break repair via break-induced replication
k	0000781	cellular_component	chromosome, telomeric region
k	0003677	molecular_function	DNA binding
k	0003678	molecular_function	DNA helicase activity
k	0003682	molecular_function	chromatin binding
k	0003688	molecular_function	DNA replication origin binding
k	0003697	molecular_function	single-stranded DNA binding
k	0004386	molecular_function	helicase activity
k	0005515	molecular_function	protein binding
k	0005524	molecular_function	ATP binding
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0005656	cellular_component	nuclear pre-replicative complex
k	0005737	cellular_component	cytoplasm
k	0006260	biological_process	DNA replication
k	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
k	0006270	biological_process	DNA replication initiation
k	0006279	biological_process	premeiotic DNA replication
k	0006368	biological_process	transcription elongation by RNA polymerase II
k	0008270	molecular_function	zinc ion binding
k	0016787	molecular_function	hydrolase activity
k	0016887	molecular_function	ATP hydrolysis activity
k	0017116	molecular_function	single-stranded DNA helicase activity
k	0030174	biological_process	regulation of DNA-templated DNA replication initiation
k	0031261	cellular_component	DNA replication preinitiation complex
k	0031507	biological_process	heterochromatin formation
k	0031509	biological_process	subtelomeric heterochromatin formation
k	0033260	biological_process	nuclear DNA replication
k	0042555	cellular_component	MCM complex
k	0043138	molecular_function	3'-5' DNA helicase activity
k	0043596	cellular_component	nuclear replication fork
k	0071162	cellular_component	CMG complex
l	0000166	molecular_function	nucleotide binding
l	0000727	biological_process	double-strand break repair via break-induced replication
l	0003677	molecular_function	DNA binding
l	0003678	molecular_function	DNA helicase activity
l	0003688	molecular_function	DNA replication origin binding
l	0003697	molecular_function	single-stranded DNA binding
l	0004386	molecular_function	helicase activity
l	0005515	molecular_function	protein binding
l	0005524	molecular_function	ATP binding
l	0005634	cellular_component	nucleus
l	0005654	cellular_component	nucleoplasm
l	0005656	cellular_component	nuclear pre-replicative complex
l	0005737	cellular_component	cytoplasm
l	0005777	cellular_component	peroxisome
l	0006260	biological_process	DNA replication
l	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
l	0006270	biological_process	DNA replication initiation
l	0006271	biological_process	DNA strand elongation involved in DNA replication
l	0006279	biological_process	premeiotic DNA replication
l	0008270	molecular_function	zinc ion binding
l	0009378	molecular_function	four-way junction helicase activity
l	0016787	molecular_function	hydrolase activity
l	0016887	molecular_function	ATP hydrolysis activity
l	0017116	molecular_function	single-stranded DNA helicase activity
l	0031261	cellular_component	DNA replication preinitiation complex
l	0042555	cellular_component	MCM complex
l	0043138	molecular_function	3'-5' DNA helicase activity
l	0043596	cellular_component	nuclear replication fork
l	0071162	cellular_component	CMG complex
l	0097373	cellular_component	MCM core complex
l	1902969	biological_process	mitotic DNA replication
l	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
m	0000166	molecular_function	nucleotide binding
m	0000727	biological_process	double-strand break repair via break-induced replication
m	0000781	cellular_component	chromosome, telomeric region
m	0003677	molecular_function	DNA binding
m	0003678	molecular_function	DNA helicase activity
m	0003682	molecular_function	chromatin binding
m	0003688	molecular_function	DNA replication origin binding
m	0003697	molecular_function	single-stranded DNA binding
m	0004386	molecular_function	helicase activity
m	0005515	molecular_function	protein binding
m	0005524	molecular_function	ATP binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005656	cellular_component	nuclear pre-replicative complex
m	0005737	cellular_component	cytoplasm
m	0006260	biological_process	DNA replication
m	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
m	0006270	biological_process	DNA replication initiation
m	0006271	biological_process	DNA strand elongation involved in DNA replication
m	0006279	biological_process	premeiotic DNA replication
m	0008270	molecular_function	zinc ion binding
m	0009378	molecular_function	four-way junction helicase activity
m	0016787	molecular_function	hydrolase activity
m	0016887	molecular_function	ATP hydrolysis activity
m	0017116	molecular_function	single-stranded DNA helicase activity
m	0030466	biological_process	silent mating-type cassette heterochromatin formation
m	0031261	cellular_component	DNA replication preinitiation complex
m	0031509	biological_process	subtelomeric heterochromatin formation
m	0033260	biological_process	nuclear DNA replication
m	0042555	cellular_component	MCM complex
m	0043138	molecular_function	3'-5' DNA helicase activity
m	0043596	cellular_component	nuclear replication fork
m	0071162	cellular_component	CMG complex
m	0097373	cellular_component	MCM core complex
m	1904931	molecular_function	MCM complex binding
n	0000727	biological_process	double-strand break repair via break-induced replication
n	0000811	cellular_component	GINS complex
n	0003674	molecular_function	molecular_function
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0006260	biological_process	DNA replication
n	0006261	biological_process	DNA-templated DNA replication
n	0031261	cellular_component	DNA replication preinitiation complex
n	0043596	cellular_component	nuclear replication fork
n	0071162	cellular_component	CMG complex
n	1902983	biological_process	DNA strand elongation involved in mitotic DNA replication
o	0000228	cellular_component	nuclear chromosome
o	0000727	biological_process	double-strand break repair via break-induced replication
o	0000811	cellular_component	GINS complex
o	0003674	molecular_function	molecular_function
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0006260	biological_process	DNA replication
o	0006261	biological_process	DNA-templated DNA replication
o	0031261	cellular_component	DNA replication preinitiation complex
o	0043596	cellular_component	nuclear replication fork
o	0071162	cellular_component	CMG complex
p	0000727	biological_process	double-strand break repair via break-induced replication
p	0000811	cellular_component	GINS complex
p	0003674	molecular_function	molecular_function
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0006260	biological_process	DNA replication
p	0006261	biological_process	DNA-templated DNA replication
p	0006270	biological_process	DNA replication initiation
p	0031261	cellular_component	DNA replication preinitiation complex
p	0043596	cellular_component	nuclear replication fork
p	0071162	cellular_component	CMG complex
q	0000727	biological_process	double-strand break repair via break-induced replication
q	0000811	cellular_component	GINS complex
q	0003674	molecular_function	molecular_function
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0006260	biological_process	DNA replication
q	0006261	biological_process	DNA-templated DNA replication
q	0031261	cellular_component	DNA replication preinitiation complex
q	0043596	cellular_component	nuclear replication fork
q	0071162	cellular_component	CMG complex
r	0000727	biological_process	double-strand break repair via break-induced replication
r	0003682	molecular_function	chromatin binding
r	0003688	molecular_function	DNA replication origin binding
r	0003697	molecular_function	single-stranded DNA binding
r	0005515	molecular_function	protein binding
r	0005634	cellular_component	nucleus
r	0006260	biological_process	DNA replication
r	0006270	biological_process	DNA replication initiation
r	0031261	cellular_component	DNA replication preinitiation complex
r	0043596	cellular_component	nuclear replication fork
r	0071162	cellular_component	CMG complex
r	1902977	biological_process	mitotic DNA replication preinitiation complex assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue ATP h 901

Chain	Residue
h	PRO545
l	VAL797
l	GLU801
h	GLY546
h	THR547
h	ALA548
h	LYS549
h	SER550
h	LEU695
l	GLU657
l	ARG708

---

site_id	AC2
Number of Residues	12
Details	binding site for residue ATP i 1001

Chain	Residue
i	ILE371
i	PRO411
i	SER412
i	THR413
i	ALA414
i	LYS415
i	SER416
i	GLN417
k	LEU406
k	ARG549
k	ILE650
k	ARG651

---

site_id	AC3
Number of Residues	16
Details	binding site for residue ATP k 801

Chain	Residue
h	HIS531
h	GLU625
h	ARG676
h	VAL807
h	ARG808
k	SER377
k	ILE378
k	PHE379
k	ASP417
k	PRO418
k	GLY419
k	THR420
k	ALA421
k	LYS422
k	SER423
k	GLN424

---

site_id	AC4
Number of Residues	11
Details	binding site for residue ATP 2 901

Chain	Residue
2	PRO545
2	GLY546
2	THR547
2	ALA548
2	LYS549
2	SER550
2	LEU695
6	GLU657
6	ARG708
6	VAL797
6	GLU801

---

site_id	AC5
Number of Residues	12
Details	binding site for residue ATP 3 1001

Chain	Residue
3	ILE371
3	PRO411
3	SER412
3	THR413
3	ALA414
3	LYS415
3	SER416
3	GLN417
5	LEU406
5	ARG549
5	ILE650
5	ARG651

---

site_id	AC6
Number of Residues	16
Details	binding site for residue ATP 5 801

Chain	Residue
2	HIS531
2	GLU625
2	ARG676
2	VAL807
2	ARG808
5	SER377
5	ILE378
5	PHE379
5	ASP417
5	PRO418
5	GLY419
5	THR420
5	ALA421
5	LYS422
5	SER423
5	GLN424

---

Functional Information from PROSITE/UniProt

site_id	PS00847
Number of Residues	9
Details	MCM_1 MCM family signature. GVCLIDEFD

Chain	Residue	Details
F	GLY602-ASP610
H	GLY627-ASP635
I	GLY475-ASP483
J	GLY634-ASP642
G	GLY468-ASP476
K	GLY519-ASP527

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	120
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3726
Details	Domain: {"description":"MCM"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	78
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	54
Details	Motif: {"description":"Arginine finger"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	105
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P33993","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---