6PT2
Crystal structure of the active delta opioid receptor in complex with the peptide agonist KGCHM07
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0022900 | biological_process | electron transport chain |
| A | 0038046 | molecular_function | G protein-coupled enkephalin receptor activity |
| A | 0042597 | cellular_component | periplasmic space |
| B | 0004930 | molecular_function | G protein-coupled receptor activity |
| B | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016020 | cellular_component | membrane |
| B | 0020037 | molecular_function | heme binding |
| B | 0022900 | biological_process | electron transport chain |
| B | 0038046 | molecular_function | G protein-coupled enkephalin receptor activity |
| B | 0042597 | cellular_component | periplasmic space |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue CLR A 1201 |
| Chain | Residue |
| A | PRO276 |
| A | ILE279 |
| A | VAL283 |
| A | ILE289 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue OLA A 1202 |
| Chain | Residue |
| A | SER106 |
| A | ALA107 |
| A | LEU110 |
| A | MET111 |
| B | PHE325 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue OLA A 1203 |
| Chain | Residue |
| A | TRP173 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue OLA B 1201 |
| Chain | Residue |
| B | TYR318 |
| B | ASP322 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue OLA B 1203 |
| Chain | Residue |
| B | TRP173 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue OLA B 1204 |
| Chain | Residue |
| A | SER204 |
| B | THR285 |
| B | LEU286 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue OLA B 1205 |
| Chain | Residue |
| B | LYS122 |
| B | MET184 |
| B | VAL185 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue OLC B 1206 |
| Chain | Residue |
| B | ILE289 |
| B | VAL296 |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSIfTLTMMCVDRYIaV |
| Chain | Residue | Details |
| A | THR134-VAL150 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 76 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 88 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 62 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
