Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6PS6

XFEL beta2 AR structure by ligand exchange from Timolol to Timolol.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0003824	molecular_function	catalytic activity
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004941	molecular_function	beta2-adrenergic receptor activity
A	0006940	biological_process	regulation of smooth muscle contraction
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
A	0009253	biological_process	peptidoglycan catabolic process
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0030430	cellular_component	host cell cytoplasm
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0044659	biological_process	viral release from host cell by cytolysis
A	0097746	biological_process	blood vessel diameter maintenance

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue TIM A 1201

Chain	Residue
A	ASP113
A	PHE289
A	PHE290
A	ASN293
A	TYR308
A	ASN312
A	VAL114
A	VAL117
A	THR118
A	TYR199
A	SER203
A	SER204
A	SER207
A	TRP286

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 A 1202

Chain	Residue
A	THR66
A	VAL67
A	THR68
A	ARG131
A	TYR141
A	SER143

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 1203

Chain	Residue
A	LYS270
A	LYS273
A	ARG328

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 A 1204

Chain	Residue
A	PHE1114
A	ASN1116
A	SER1117
A	ASN1132

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 A 1205

Chain	Residue
A	THR1142
A	ASN1144
A	ARG1145

site_id	AC6
Number of Residues	5
Details	binding site for residue CLR A 1206

Chain	Residue
A	TYR70
A	SER74
A	CYS77
A	ILE154
A	TRP158

site_id	AC7
Number of Residues	2
Details	binding site for residue OLC A 1207

Chain	Residue
A	TRP122
A	VAL160

site_id	AC8
Number of Residues	4
Details	binding site for residue OLC A 1208

Chain	Residue
A	ASP130
A	PHE133
A	LEU144
A	LEU145

site_id	AC9
Number of Residues	3
Details	binding site for residue OLC A 1209

Chain	Residue
A	ILE55
A	GLN65
A	THR73

site_id	AD1
Number of Residues	6
Details	binding site for residue OLC A 1210

Chain	Residue
A	PHE49
A	VAL52
A	GLN197
A	VAL297
A	LEU339
A	OLA1214

site_id	AD2
Number of Residues	2
Details	binding site for residue OLC A 1211

Chain	Residue
A	ALA59
A	OLA1214

site_id	AD3
Number of Residues	3
Details	binding site for residue OLC A 1212

Chain	Residue
A	TRP173
A	ASN196
A	LEU340

site_id	AD4
Number of Residues	2
Details	binding site for residue OLC A 1213

Chain	Residue
A	PHE223
A	LYS273

site_id	AD5
Number of Residues	3
Details	binding site for residue OLA A 1214

Chain	Residue
A	THR56
A	OLC1210
A	OLC1211

site_id	AD6
Number of Residues	4
Details	binding site for residue OLA A 1215

Chain	Residue
A	MET96
A	THR100
A	PHE101
A	PHE217

site_id	AD7
Number of Residues	1
Details	binding site for residue OLA A 1216

Chain	Residue
A	TRP313

site_id	AD8
Number of Residues	1
Details	binding site for residue OLA A 1217

Chain	Residue
A	THR283

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIwTLCVIAVDRYFaI

Chain	Residue	Details
A	ALA119-ILE135

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"24056936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LDE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	32
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"24056936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LDE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	36
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"24056936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LDE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"24056936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LDE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"24056936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LDE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"24056936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LDE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"24056936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LDE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18547522","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3D4S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17952055","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17962520","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2RH1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"8521811","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"27481942","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	1
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"17962520","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18547522","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2540197","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27481942","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)