6PRZ
XFEL beta2 AR structure by ligand exchange from Alprenolol to Alprenolol.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003796 | molecular_function | lysozyme activity |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004941 | molecular_function | beta2-adrenergic receptor activity |
| A | 0006940 | biological_process | regulation of smooth muscle contraction |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| A | 0009253 | biological_process | peptidoglycan catabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0016998 | biological_process | cell wall macromolecule catabolic process |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0044659 | biological_process | viral release from host cell by cytolysis |
| A | 0097746 | biological_process | blood vessel diameter maintenance |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue JTZ A 1201 |
| Chain | Residue |
| A | ASP113 |
| A | ASN312 |
| A | VAL114 |
| A | PHE193 |
| A | SER203 |
| A | SER207 |
| A | TRP286 |
| A | PHE289 |
| A | PHE290 |
| A | ASN293 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CLR A 1202 |
| Chain | Residue |
| A | TYR70 |
| A | CYS77 |
| A | ARG151 |
| A | TRP158 |
| A | OLC1203 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue OLC A 1203 |
| Chain | Residue |
| A | ILE55 |
| A | GLN65 |
| A | THR73 |
| A | CLR1202 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue OLC A 1204 |
| Chain | Residue |
| A | VAL129 |
| A | ASP130 |
| A | LEU144 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue OLC A 1205 |
| Chain | Residue |
| A | PHE223 |
| A | LYS273 |
| A | GLY276 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue OLA A 1206 |
| Chain | Residue |
| A | THR56 |
| A | ILE298 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue OLA A 1207 |
| Chain | Residue |
| A | THR100 |
| A | PHE101 |
| A | TYR132 |
| A | PHE217 |
| A | VAL218 |
| A | ARG221 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 1208 |
| Chain | Residue |
| A | VAL67 |
| A | THR68 |
| A | ARG131 |
| A | TYR141 |
| A | GLN142 |
| A | SER143 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 1209 |
| Chain | Residue |
| A | LYS270 |
| A | LYS273 |
| A | ARG328 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 1210 |
| Chain | Residue |
| A | PHE1114 |
| A | ASN1116 |
| A | SER1117 |
| A | ASN1132 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 1211 |
| Chain | Residue |
| A | THR1142 |
| A | PRO1143 |
| A | ASN1144 |
| A | ARG1145 |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIwTLCVIAVDRYFaI |
| Chain | Residue | Details |
| A | ALA119-ILE135 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Topological domain: {"description":"Cytoplasmic"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 37 |
| Details | Topological domain: {"description":"Extracellular"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18547522","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3D4S","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17952055","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17962520","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2RH1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"8521811","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"27481942","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"17962520","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18547522","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2540197","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27481942","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
