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6PPL

Cryo-EM structure of human NatE complex (NatA/Naa50)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004596molecular_functionpeptide alpha-N-acetyltransferase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006338biological_processchromatin remodeling
A0006474biological_processN-terminal protein amino acid acetylation
A0007064biological_processmitotic sister chromatid cohesion
A0010485molecular_functionhistone H4 acetyltransferase activity
A0016746molecular_functionacyltransferase activity
A0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
A0031415cellular_componentNatA complex
A0034087biological_processestablishment of mitotic sister chromatid cohesion
A0052858molecular_functionpeptidyl-lysine acetyltransferase activity
A0070062cellular_componentextracellular exosome
A0071962biological_processmitotic sister chromatid cohesion, centromeric
B0001525biological_processangiogenesis
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005667cellular_componenttranscription regulator complex
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006474biological_processN-terminal protein amino acid acetylation
B0016020cellular_componentmembrane
B0016407molecular_functionacetyltransferase activity
B0016604cellular_componentnuclear body
B0030154biological_processcell differentiation
B0031415cellular_componentNatA complex
B0043022molecular_functionribosome binding
B0043066biological_processnegative regulation of apoptotic process
B0043231cellular_componentintracellular membrane-bounded organelle
B0045893biological_processpositive regulation of DNA-templated transcription
B0050821biological_processprotein stabilization
C0004596molecular_functionpeptide alpha-N-acetyltransferase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006473biological_processprotein acetylation
C0006474biological_processN-terminal protein amino acid acetylation
C0006475biological_processinternal protein amino acid acetylation
C0008080molecular_functionN-acetyltransferase activity
C0016020cellular_componentmembrane
C0016407molecular_functionacetyltransferase activity
C0016746molecular_functionacyltransferase activity
C0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
C0031415cellular_componentNatA complex
C0043022molecular_functionribosome binding
C0051276biological_processchromosome organization
C1990189molecular_functionpeptide-serine-alpha-N-acetyltransferase activity
C1990190molecular_functionpeptide-glutamate-alpha-N-acetyltransferase activity
C2000719biological_processnegative regulation of maintenance of mitotic sister chromatid cohesion, centromeric
Functional Information from PDB Data
site_idAC1
Number of Residues18
Detailsbinding site for residue ACO A 201
ChainResidue
AILE26
AGLY89
ATHR90
AHIS112
AVAL113
AGLN114
AASN117
ASER119
APHE123
ALYS126
ALEU77
AGLY78
ACYS79
AARG84
AARG85
ALEU86
AGLY87
AILE88

site_idAC2
Number of Residues11
Detailsbinding site for residue IHP B 901
ChainResidue
BLYS416
BLYS419
BHIS420
BLYS447
BLYS450
BTYR451
BLYS556
CHIS16
CLYS51
CLYS78
CSER80

site_idAC3
Number of Residues16
Detailsbinding site for residue ACO C 901
ChainResidue
AASP53
CLEU22
CLEU75
CALA76
CVAL77
CARG82
CARG83
CGLY85
CLEU86
CALA87
CGLN88
CALA117
CHIS120
CLEU121
CTYR122
CTHR125

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330
ChainResidueDetails
CMET1
BLYS735
BLYS756

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:27708256
ChainResidueDetails
CLYS136
BSER537
BSER855

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER182
AASN117

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
CSER186

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER205
ALYS37

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine; by IKKB => ECO:0000269|PubMed:19716809
ChainResidueDetails
CSER209

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
CSER213
CSER216

222926

PDB entries from 2024-07-24

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