6PPG

Crystal structure of IL17FF bound to Fab fragments of MCAF5352A

Functional Information from GO Data

Chain	GOid	namespace	contents
F	0001819	biological_process	positive regulation of cytokine production
F	0002225	biological_process	positive regulation of antimicrobial peptide production
F	0002250	biological_process	adaptive immune response
F	0005125	molecular_function	cytokine activity
F	0005126	molecular_function	cytokine receptor binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0006954	biological_process	inflammatory response
F	0016525	biological_process	negative regulation of angiogenesis
F	0017015	biological_process	regulation of transforming growth factor beta receptor signaling pathway
F	0019955	molecular_function	cytokine binding
F	0032645	biological_process	regulation of granulocyte macrophage colony-stimulating factor production
F	0032663	biological_process	regulation of interleukin-2 production
F	0032675	biological_process	regulation of interleukin-6 production
F	0032677	biological_process	regulation of interleukin-8 production
F	0032755	biological_process	positive regulation of interleukin-6 production
F	0032761	biological_process	positive regulation of lymphotoxin A production
F	0042803	molecular_function	protein homodimerization activity
F	0045087	biological_process	innate immune response
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0046982	molecular_function	protein heterodimerization activity
F	0050829	biological_process	defense response to Gram-negative bacterium
F	0050830	biological_process	defense response to Gram-positive bacterium
F	0051216	biological_process	cartilage development
F	0097400	biological_process	interleukin-17-mediated signaling pathway
F	1900017	biological_process	positive regulation of cytokine production involved in inflammatory response
F	2000340	biological_process	positive regulation of chemokine (C-X-C motif) ligand 1 production
G	0001819	biological_process	positive regulation of cytokine production
G	0002225	biological_process	positive regulation of antimicrobial peptide production
G	0002250	biological_process	adaptive immune response
G	0005125	molecular_function	cytokine activity
G	0005126	molecular_function	cytokine receptor binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0006954	biological_process	inflammatory response
G	0016525	biological_process	negative regulation of angiogenesis
G	0017015	biological_process	regulation of transforming growth factor beta receptor signaling pathway
G	0019955	molecular_function	cytokine binding
G	0032645	biological_process	regulation of granulocyte macrophage colony-stimulating factor production
G	0032663	biological_process	regulation of interleukin-2 production
G	0032675	biological_process	regulation of interleukin-6 production
G	0032677	biological_process	regulation of interleukin-8 production
G	0032755	biological_process	positive regulation of interleukin-6 production
G	0032761	biological_process	positive regulation of lymphotoxin A production
G	0042803	molecular_function	protein homodimerization activity
G	0045087	biological_process	innate immune response
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0046982	molecular_function	protein heterodimerization activity
G	0050829	biological_process	defense response to Gram-negative bacterium
G	0050830	biological_process	defense response to Gram-positive bacterium
G	0051216	biological_process	cartilage development
G	0097400	biological_process	interleukin-17-mediated signaling pathway
G	1900017	biological_process	positive regulation of cytokine production involved in inflammatory response
G	2000340	biological_process	positive regulation of chemokine (C-X-C motif) ligand 1 production

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
B	TYR204-HIS210
A	TYR193-HIS199

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19838198

Chain	Residue	Details
F	ASN53
G	ASN53

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