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6PPE

ClpP and ClpX IGF loop in ClpX-ClpP complex with D7 symmetry

Functional Information from GO Data
ChainGOidnamespacecontents
10005524molecular_functionATP binding
10006457biological_processprotein folding
10016887molecular_functionATP hydrolysis activity
10051082molecular_functionunfolded protein binding
10140662molecular_functionATP-dependent protein folding chaperone
20005524molecular_functionATP binding
20006457biological_processprotein folding
20016887molecular_functionATP hydrolysis activity
20051082molecular_functionunfolded protein binding
20140662molecular_functionATP-dependent protein folding chaperone
30005524molecular_functionATP binding
30006457biological_processprotein folding
30016887molecular_functionATP hydrolysis activity
30051082molecular_functionunfolded protein binding
30140662molecular_functionATP-dependent protein folding chaperone
A0004176molecular_functionATP-dependent peptidase activity
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006508biological_processproteolysis
A0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0009266biological_processresponse to temperature stimulus
A0009314biological_processresponse to radiation
A0009368cellular_componentendopeptidase Clp complex
A0009376cellular_componentHslUV protease complex
A0009408biological_processresponse to heat
A0010498biological_processproteasomal protein catabolic process
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0042802molecular_functionidentical protein binding
A0043068biological_processpositive regulation of programmed cell death
A0051117molecular_functionATPase binding
B0004176molecular_functionATP-dependent peptidase activity
B0004252molecular_functionserine-type endopeptidase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006508biological_processproteolysis
B0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
B0008233molecular_functionpeptidase activity
B0008236molecular_functionserine-type peptidase activity
B0009266biological_processresponse to temperature stimulus
B0009314biological_processresponse to radiation
B0009368cellular_componentendopeptidase Clp complex
B0009376cellular_componentHslUV protease complex
B0009408biological_processresponse to heat
B0010498biological_processproteasomal protein catabolic process
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0042802molecular_functionidentical protein binding
B0043068biological_processpositive regulation of programmed cell death
B0051117molecular_functionATPase binding
C0004176molecular_functionATP-dependent peptidase activity
C0004252molecular_functionserine-type endopeptidase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006508biological_processproteolysis
C0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
C0008233molecular_functionpeptidase activity
C0008236molecular_functionserine-type peptidase activity
C0009266biological_processresponse to temperature stimulus
C0009314biological_processresponse to radiation
C0009368cellular_componentendopeptidase Clp complex
C0009376cellular_componentHslUV protease complex
C0009408biological_processresponse to heat
C0010498biological_processproteasomal protein catabolic process
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0042802molecular_functionidentical protein binding
C0043068biological_processpositive regulation of programmed cell death
C0051117molecular_functionATPase binding
D0004176molecular_functionATP-dependent peptidase activity
D0004252molecular_functionserine-type endopeptidase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006508biological_processproteolysis
D0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
D0008233molecular_functionpeptidase activity
D0008236molecular_functionserine-type peptidase activity
D0009266biological_processresponse to temperature stimulus
D0009314biological_processresponse to radiation
D0009368cellular_componentendopeptidase Clp complex
D0009376cellular_componentHslUV protease complex
D0009408biological_processresponse to heat
D0010498biological_processproteasomal protein catabolic process
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0042802molecular_functionidentical protein binding
D0043068biological_processpositive regulation of programmed cell death
D0051117molecular_functionATPase binding
E0004176molecular_functionATP-dependent peptidase activity
E0004252molecular_functionserine-type endopeptidase activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006508biological_processproteolysis
E0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
E0008233molecular_functionpeptidase activity
E0008236molecular_functionserine-type peptidase activity
E0009266biological_processresponse to temperature stimulus
E0009314biological_processresponse to radiation
E0009368cellular_componentendopeptidase Clp complex
E0009376cellular_componentHslUV protease complex
E0009408biological_processresponse to heat
E0010498biological_processproteasomal protein catabolic process
E0016020cellular_componentmembrane
E0016787molecular_functionhydrolase activity
E0042802molecular_functionidentical protein binding
E0043068biological_processpositive regulation of programmed cell death
E0051117molecular_functionATPase binding
F0004176molecular_functionATP-dependent peptidase activity
F0004252molecular_functionserine-type endopeptidase activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006508biological_processproteolysis
F0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
F0008233molecular_functionpeptidase activity
F0008236molecular_functionserine-type peptidase activity
F0009266biological_processresponse to temperature stimulus
F0009314biological_processresponse to radiation
F0009368cellular_componentendopeptidase Clp complex
F0009376cellular_componentHslUV protease complex
F0009408biological_processresponse to heat
F0010498biological_processproteasomal protein catabolic process
F0016020cellular_componentmembrane
F0016787molecular_functionhydrolase activity
F0042802molecular_functionidentical protein binding
F0043068biological_processpositive regulation of programmed cell death
F0051117molecular_functionATPase binding
G0004176molecular_functionATP-dependent peptidase activity
G0004252molecular_functionserine-type endopeptidase activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0006508biological_processproteolysis
G0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
G0008233molecular_functionpeptidase activity
G0008236molecular_functionserine-type peptidase activity
G0009266biological_processresponse to temperature stimulus
G0009314biological_processresponse to radiation
G0009368cellular_componentendopeptidase Clp complex
G0009376cellular_componentHslUV protease complex
G0009408biological_processresponse to heat
G0010498biological_processproteasomal protein catabolic process
G0016020cellular_componentmembrane
G0016787molecular_functionhydrolase activity
G0042802molecular_functionidentical protein binding
G0043068biological_processpositive regulation of programmed cell death
G0051117molecular_functionATPase binding
H0004176molecular_functionATP-dependent peptidase activity
H0004252molecular_functionserine-type endopeptidase activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006508biological_processproteolysis
H0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
H0008233molecular_functionpeptidase activity
H0008236molecular_functionserine-type peptidase activity
H0009266biological_processresponse to temperature stimulus
H0009314biological_processresponse to radiation
H0009368cellular_componentendopeptidase Clp complex
H0009376cellular_componentHslUV protease complex
H0009408biological_processresponse to heat
H0010498biological_processproteasomal protein catabolic process
H0016020cellular_componentmembrane
H0016787molecular_functionhydrolase activity
H0042802molecular_functionidentical protein binding
H0043068biological_processpositive regulation of programmed cell death
H0051117molecular_functionATPase binding
I0004176molecular_functionATP-dependent peptidase activity
I0004252molecular_functionserine-type endopeptidase activity
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0006508biological_processproteolysis
I0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
I0008233molecular_functionpeptidase activity
I0008236molecular_functionserine-type peptidase activity
I0009266biological_processresponse to temperature stimulus
I0009314biological_processresponse to radiation
I0009368cellular_componentendopeptidase Clp complex
I0009376cellular_componentHslUV protease complex
I0009408biological_processresponse to heat
I0010498biological_processproteasomal protein catabolic process
I0016020cellular_componentmembrane
I0016787molecular_functionhydrolase activity
I0042802molecular_functionidentical protein binding
I0043068biological_processpositive regulation of programmed cell death
I0051117molecular_functionATPase binding
J0004176molecular_functionATP-dependent peptidase activity
J0004252molecular_functionserine-type endopeptidase activity
J0005515molecular_functionprotein binding
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0006508biological_processproteolysis
J0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
J0008233molecular_functionpeptidase activity
J0008236molecular_functionserine-type peptidase activity
J0009266biological_processresponse to temperature stimulus
J0009314biological_processresponse to radiation
J0009368cellular_componentendopeptidase Clp complex
J0009376cellular_componentHslUV protease complex
J0009408biological_processresponse to heat
J0010498biological_processproteasomal protein catabolic process
J0016020cellular_componentmembrane
J0016787molecular_functionhydrolase activity
J0042802molecular_functionidentical protein binding
J0043068biological_processpositive regulation of programmed cell death
J0051117molecular_functionATPase binding
K0004176molecular_functionATP-dependent peptidase activity
K0004252molecular_functionserine-type endopeptidase activity
K0005515molecular_functionprotein binding
K0005737cellular_componentcytoplasm
K0005829cellular_componentcytosol
K0006508biological_processproteolysis
K0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
K0008233molecular_functionpeptidase activity
K0008236molecular_functionserine-type peptidase activity
K0009266biological_processresponse to temperature stimulus
K0009314biological_processresponse to radiation
K0009368cellular_componentendopeptidase Clp complex
K0009376cellular_componentHslUV protease complex
K0009408biological_processresponse to heat
K0010498biological_processproteasomal protein catabolic process
K0016020cellular_componentmembrane
K0016787molecular_functionhydrolase activity
K0042802molecular_functionidentical protein binding
K0043068biological_processpositive regulation of programmed cell death
K0051117molecular_functionATPase binding
L0004176molecular_functionATP-dependent peptidase activity
L0004252molecular_functionserine-type endopeptidase activity
L0005515molecular_functionprotein binding
L0005737cellular_componentcytoplasm
L0005829cellular_componentcytosol
L0006508biological_processproteolysis
L0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
L0008233molecular_functionpeptidase activity
L0008236molecular_functionserine-type peptidase activity
L0009266biological_processresponse to temperature stimulus
L0009314biological_processresponse to radiation
L0009368cellular_componentendopeptidase Clp complex
L0009376cellular_componentHslUV protease complex
L0009408biological_processresponse to heat
L0010498biological_processproteasomal protein catabolic process
L0016020cellular_componentmembrane
L0016787molecular_functionhydrolase activity
L0042802molecular_functionidentical protein binding
L0043068biological_processpositive regulation of programmed cell death
L0051117molecular_functionATPase binding
M0004176molecular_functionATP-dependent peptidase activity
M0004252molecular_functionserine-type endopeptidase activity
M0005515molecular_functionprotein binding
M0005737cellular_componentcytoplasm
M0005829cellular_componentcytosol
M0006508biological_processproteolysis
M0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
M0008233molecular_functionpeptidase activity
M0008236molecular_functionserine-type peptidase activity
M0009266biological_processresponse to temperature stimulus
M0009314biological_processresponse to radiation
M0009368cellular_componentendopeptidase Clp complex
M0009376cellular_componentHslUV protease complex
M0009408biological_processresponse to heat
M0010498biological_processproteasomal protein catabolic process
M0016020cellular_componentmembrane
M0016787molecular_functionhydrolase activity
M0042802molecular_functionidentical protein binding
M0043068biological_processpositive regulation of programmed cell death
M0051117molecular_functionATPase binding
N0004176molecular_functionATP-dependent peptidase activity
N0004252molecular_functionserine-type endopeptidase activity
N0005515molecular_functionprotein binding
N0005737cellular_componentcytoplasm
N0005829cellular_componentcytosol
N0006508biological_processproteolysis
N0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
N0008233molecular_functionpeptidase activity
N0008236molecular_functionserine-type peptidase activity
N0009266biological_processresponse to temperature stimulus
N0009314biological_processresponse to radiation
N0009368cellular_componentendopeptidase Clp complex
N0009376cellular_componentHslUV protease complex
N0009408biological_processresponse to heat
N0010498biological_processproteasomal protein catabolic process
N0016020cellular_componentmembrane
N0016787molecular_functionhydrolase activity
N0042802molecular_functionidentical protein binding
N0043068biological_processpositive regulation of programmed cell death
N0051117molecular_functionATPase binding
O0005524molecular_functionATP binding
O0006457biological_processprotein folding
O0016887molecular_functionATP hydrolysis activity
O0051082molecular_functionunfolded protein binding
O0140662molecular_functionATP-dependent protein folding chaperone
P0005524molecular_functionATP binding
P0006457biological_processprotein folding
P0016887molecular_functionATP hydrolysis activity
P0051082molecular_functionunfolded protein binding
P0140662molecular_functionATP-dependent protein folding chaperone
Q0005524molecular_functionATP binding
Q0006457biological_processprotein folding
Q0016887molecular_functionATP hydrolysis activity
Q0051082molecular_functionunfolded protein binding
Q0140662molecular_functionATP-dependent protein folding chaperone
R0005524molecular_functionATP binding
R0006457biological_processprotein folding
R0016887molecular_functionATP hydrolysis activity
R0051082molecular_functionunfolded protein binding
R0140662molecular_functionATP-dependent protein folding chaperone
S0005524molecular_functionATP binding
S0006457biological_processprotein folding
S0016887molecular_functionATP hydrolysis activity
S0051082molecular_functionunfolded protein binding
S0140662molecular_functionATP-dependent protein folding chaperone
T0005524molecular_functionATP binding
T0006457biological_processprotein folding
T0016887molecular_functionATP hydrolysis activity
T0051082molecular_functionunfolded protein binding
T0140662molecular_functionATP-dependent protein folding chaperone
U0005524molecular_functionATP binding
U0006457biological_processprotein folding
U0016887molecular_functionATP hydrolysis activity
U0051082molecular_functionunfolded protein binding
U0140662molecular_functionATP-dependent protein folding chaperone
V0005524molecular_functionATP binding
V0006457biological_processprotein folding
V0016887molecular_functionATP hydrolysis activity
V0051082molecular_functionunfolded protein binding
V0140662molecular_functionATP-dependent protein folding chaperone
X0005524molecular_functionATP binding
X0006457biological_processprotein folding
X0016887molecular_functionATP hydrolysis activity
X0051082molecular_functionunfolded protein binding
X0140662molecular_functionATP-dependent protein folding chaperone
Y0005524molecular_functionATP binding
Y0006457biological_processprotein folding
Y0016887molecular_functionATP hydrolysis activity
Y0051082molecular_functionunfolded protein binding
Y0140662molecular_functionATP-dependent protein folding chaperone
Z0005524molecular_functionATP binding
Z0006457biological_processprotein folding
Z0016887molecular_functionATP hydrolysis activity
Z0051082molecular_functionunfolded protein binding
Z0140662molecular_functionATP-dependent protein folding chaperone
Functional Information from PROSITE/UniProt
site_idPS00381
Number of Residues12
DetailsCLP_PROTEASE_SER Endopeptidase Clp serine active site. TicMGqAASMGA
ChainResidueDetails
ATHR89-ALA100

site_idPS00382
Number of Residues14
DetailsCLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RfclPnsrVMIHQP
ChainResidueDetails
AARG111-PRO124

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsActive site: {"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues28
DetailsActive site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idMCSA1
Number of Residues5
DetailsM-CSA 912
ChainResidueDetails
AGLY68electrostatic stabiliser
ASER97covalent catalysis, proton shuttle (general acid/base)
AMET98electrostatic stabiliser
AHIS122proton shuttle (general acid/base)
AASP171electrostatic stabiliser, modifies pKa

site_idMCSA10
Number of Residues5
DetailsM-CSA 912
ChainResidueDetails
JGLY68electrostatic stabiliser
JSER97covalent catalysis, proton shuttle (general acid/base)
JMET98electrostatic stabiliser
JHIS122proton shuttle (general acid/base)
JASP171electrostatic stabiliser, modifies pKa

site_idMCSA11
Number of Residues5
DetailsM-CSA 912
ChainResidueDetails
KGLY68electrostatic stabiliser
KSER97covalent catalysis, proton shuttle (general acid/base)
KMET98electrostatic stabiliser
KHIS122proton shuttle (general acid/base)
KASP171electrostatic stabiliser, modifies pKa

site_idMCSA12
Number of Residues5
DetailsM-CSA 912
ChainResidueDetails
LGLY68electrostatic stabiliser
LSER97covalent catalysis, proton shuttle (general acid/base)
LMET98electrostatic stabiliser
LHIS122proton shuttle (general acid/base)
LASP171electrostatic stabiliser, modifies pKa

site_idMCSA13
Number of Residues5
DetailsM-CSA 912
ChainResidueDetails
MGLY68electrostatic stabiliser
MSER97covalent catalysis, proton shuttle (general acid/base)
MMET98electrostatic stabiliser
MHIS122proton shuttle (general acid/base)
MASP171electrostatic stabiliser, modifies pKa

site_idMCSA14
Number of Residues5
DetailsM-CSA 912
ChainResidueDetails
NGLY68electrostatic stabiliser
NSER97covalent catalysis, proton shuttle (general acid/base)
NMET98electrostatic stabiliser
NHIS122proton shuttle (general acid/base)
NASP171electrostatic stabiliser, modifies pKa

site_idMCSA2
Number of Residues5
DetailsM-CSA 912
ChainResidueDetails
BGLY68electrostatic stabiliser
BSER97covalent catalysis, proton shuttle (general acid/base)
BMET98electrostatic stabiliser
BHIS122proton shuttle (general acid/base)
BASP171electrostatic stabiliser, modifies pKa

site_idMCSA3
Number of Residues5
DetailsM-CSA 912
ChainResidueDetails
CGLY68electrostatic stabiliser
CSER97covalent catalysis, proton shuttle (general acid/base)
CMET98electrostatic stabiliser
CHIS122proton shuttle (general acid/base)
CASP171electrostatic stabiliser, modifies pKa

site_idMCSA4
Number of Residues5
DetailsM-CSA 912
ChainResidueDetails
DGLY68electrostatic stabiliser
DSER97covalent catalysis, proton shuttle (general acid/base)
DMET98electrostatic stabiliser
DHIS122proton shuttle (general acid/base)
DASP171electrostatic stabiliser, modifies pKa

site_idMCSA5
Number of Residues5
DetailsM-CSA 912
ChainResidueDetails
EGLY68electrostatic stabiliser
ESER97covalent catalysis, proton shuttle (general acid/base)
EMET98electrostatic stabiliser
EHIS122proton shuttle (general acid/base)
EASP171electrostatic stabiliser, modifies pKa

site_idMCSA6
Number of Residues5
DetailsM-CSA 912
ChainResidueDetails
FGLY68electrostatic stabiliser
FSER97covalent catalysis, proton shuttle (general acid/base)
FMET98electrostatic stabiliser
FHIS122proton shuttle (general acid/base)
FASP171electrostatic stabiliser, modifies pKa

site_idMCSA7
Number of Residues5
DetailsM-CSA 912
ChainResidueDetails
GGLY68electrostatic stabiliser
GSER97covalent catalysis, proton shuttle (general acid/base)
GMET98electrostatic stabiliser
GHIS122proton shuttle (general acid/base)
GASP171electrostatic stabiliser, modifies pKa

site_idMCSA8
Number of Residues5
DetailsM-CSA 912
ChainResidueDetails
HGLY68electrostatic stabiliser
HSER97covalent catalysis, proton shuttle (general acid/base)
HMET98electrostatic stabiliser
HHIS122proton shuttle (general acid/base)
HASP171electrostatic stabiliser, modifies pKa

site_idMCSA9
Number of Residues5
DetailsM-CSA 912
ChainResidueDetails
IGLY68electrostatic stabiliser
ISER97covalent catalysis, proton shuttle (general acid/base)
IMET98electrostatic stabiliser
IHIS122proton shuttle (general acid/base)
IASP171electrostatic stabiliser, modifies pKa

239492

PDB entries from 2025-07-30

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