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6PO9

Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 7-(3-(Aminomethyl)-4-(pyridin-2-ylmethoxy)phenyl)-4-methylquinolin-2-amine

Functional Information from GO Data
ChainGOidnamespacecontents
A0004517molecular_functionnitric-oxide synthase activity
A0006809biological_processnitric oxide biosynthetic process
B0004517molecular_functionnitric-oxide synthase activity
B0006809biological_processnitric oxide biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue HEM A 801
ChainResidue
ATRP414
ATYR711
AH4B802
AOS7803
AHOH901
AHOH926
AHOH945
AARG419
ACYS420
APHE589
ASER590
ATRP592
AGLU597
ATRP683
APHE709

site_idAC2
Number of Residues16
Detailsbinding site for residue H4B A 802
ChainResidue
ASER339
AMET341
AARG601
AVAL682
ATRP683
AHEM801
AHOH915
AHOH945
AHOH1001
AHOH1040
AHOH1046
BTRP681
BPHE696
BHIS697
BGLN698
BGLU699

site_idAC3
Number of Residues13
Detailsbinding site for residue OS7 A 803
ChainResidue
AMET341
AHIS342
AVAL572
AASN574
APHE589
ATRP592
AGLU597
ATRP683
AHEM801
AHOH928
AHOH964
AHOH1060
BTRP311

site_idAC4
Number of Residues4
Detailsbinding site for residue GOL A 804
ChainResidue
AGLN369
AARG674
AHOH962
AHOH1079

site_idAC5
Number of Residues6
Detailsbinding site for residue GOL A 805
ChainResidue
ALYS411
ALEU429
AGLN430
AVAL431
AHOH956
AHOH985

site_idAC6
Number of Residues4
Detailsbinding site for residue ZN B 801
ChainResidue
ACYS331
ACYS336
BCYS331
BCYS336

site_idAC7
Number of Residues16
Detailsbinding site for residue HEM B 802
ChainResidue
BTRP414
BARG419
BCYS420
BSER462
BPHE589
BSER590
BTRP592
BGLU597
BPHE709
BTYR711
BH4B803
BOS7804
BHOH901
BHOH916
BHOH969
BHOH1030

site_idAC8
Number of Residues15
Detailsbinding site for residue H4B B 803
ChainResidue
ATRP681
APHE696
AHIS697
AGLN698
AGLU699
BSER339
BMET341
BARG601
BVAL682
BTRP683
BHEM802
BHOH940
BHOH969
BHOH991
BHOH1022

site_idAC9
Number of Residues13
Detailsbinding site for residue OS7 B 804
ChainResidue
BHEM802
BHOH969
BHOH975
ATRP311
BHIS342
BVAL572
BASN574
BPHE589
BTRP592
BTYR593
BGLU597
BTRP683
BTYR711

site_idAD1
Number of Residues3
Detailsbinding site for residue GOL B 805
ChainResidue
BGLN369
BARG674
BHOH973

Functional Information from PROSITE/UniProt
site_idPS60001
Number of Residues8
DetailsNOS Nitric oxide synthase (NOS) signature. RCVGRIqW
ChainResidueDetails
AARG419-TRP426

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsBINDING: BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N
ChainResidueDetails
ASER339
BSER339
BGLN483
BTRP592
BTYR593
BGLU597
BVAL682
BTRP683
BPHE696
BTYR711
AGLN483
ATRP592
ATYR593
AGLU597
AVAL682
ATRP683
APHE696
ATYR711

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: axial binding residue => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N
ChainResidueDetails
ACYS420
BCYS420

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PDB entries from 2024-07-24

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