6PNZ

The structure of the Aspartate Transcarbamoylase trimer from Staphylococcus aureus complexed with PALA at 2.27 Resolution.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004070	molecular_function	aspartate carbamoyltransferase activity
A	0005829	cellular_component	cytosol
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006520	biological_process	amino acid metabolic process
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0044205	biological_process	'de novo' UMP biosynthetic process
B	0004070	molecular_function	aspartate carbamoyltransferase activity
B	0005829	cellular_component	cytosol
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006520	biological_process	amino acid metabolic process
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0044205	biological_process	'de novo' UMP biosynthetic process
C	0004070	molecular_function	aspartate carbamoyltransferase activity
C	0005829	cellular_component	cytosol
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006520	biological_process	amino acid metabolic process
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
C	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue PAL A 301

Chain	Residue
A	SER48
A	PRO252
A	ALA253
A	HOH410
A	HOH440
B	SER75
B	LYS78
A	THR49
A	ARG50
A	THR51
A	ARG100
A	HIS127
A	ARG160
A	ARG210
A	GLN212

---

site_id	AC2
Number of Residues	15
Details	binding site for residue PAL B 301

Chain	Residue
B	SER48
B	THR49
B	ARG50
B	THR51
B	ARG100
B	HIS127
B	ARG160
B	ARG210
B	GLN212
B	ALA253
B	HOH410
B	HOH421
B	HOH422
C	SER75
C	LYS78

---

site_id	AC3
Number of Residues	14
Details	binding site for residue PAL C 301

Chain	Residue
A	SER75
A	LYS78
C	SER48
C	THR49
C	ARG50
C	THR51
C	ARG100
C	HIS127
C	ARG160
C	ARG210
C	GLN212
C	PRO252
C	ALA253
C	HOH404

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Functional Information from PROSITE/UniProt

site_id	PS00097
Number of Residues	8
Details	CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FfEnSTRT

Chain	Residue	Details
A	PHE44-THR51

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00001","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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