Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6PNM

Human GSTO1-1 complexed with 2-chloro-N-(4-chloro-3-(morpholinosulfonyl)phenyl)acetamide

Functional Information from GO Data
ChainGOidnamespacecontents
A0004364molecular_functionglutathione transferase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006749biological_processglutathione metabolic process
A0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0014810biological_processpositive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
A0016491molecular_functionoxidoreductase activity
A0016740molecular_functiontransferase activity
A0019852biological_processL-ascorbic acid metabolic process
A0042178biological_processxenobiotic catabolic process
A0045174molecular_functionglutathione dehydrogenase (ascorbate) activity
A0050610molecular_functionmethylarsonate reductase activity
A0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
A0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
A0070062cellular_componentextracellular exosome
A0071243biological_processcellular response to arsenic-containing substance
A0098869biological_processcellular oxidant detoxification
Functional Information from PDB Data
site_idAC1
Number of Residues18
Detailsbinding site for residue XX0 A 1001
ChainResidue
AMET29
AILE131
AARG183
ATRP222
APHE225
ALEU226
ATYR229
ATLA1006
AHOH1152
AHOH1207
APHE31
ACYS32
APRO33
APHE34
ALEU56
AVAL72
AVAL127
AGLY128

site_idAC2
Number of Residues8
Detailsbinding site for residue SO4 A 1002
ChainResidue
AARG39
AHIS49
AVAL51
AHOH1120
AHOH1147
AHOH1182
AHOH1231
AHOH1278

site_idAC3
Number of Residues2
Detailsbinding site for residue SO4 A 1003
ChainResidue
ASER129
AARG132

site_idAC4
Number of Residues6
Detailsbinding site for residue SO4 A 1004
ChainResidue
AGLU21
AGLY22
ASER78
AGLN79
AHOH1153
AHOH1154

site_idAC5
Number of Residues8
Detailsbinding site for residue SO4 A 1005
ChainResidue
AARG30
ALYS136
AHOH1111
AHOH1120
AHOH1178
AHOH1182
AHOH1185
AHOH1260

site_idAC6
Number of Residues10
Detailsbinding site for residue TLA A 1006
ChainResidue
APHE34
ALEU71
AVAL72
APRO73
AGLU85
ASER86
AXX01001
AHOH1116
AHOH1117
AHOH1189

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:10783391
ChainResidueDetails
ACYS32

site_idSWS_FT_FI2
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:10783391, ECO:0000269|PubMed:21106529
ChainResidueDetails
ALYS59
AVAL72
AGLU85

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N-acetylserine => ECO:0007744|PubMed:19413330
ChainResidueDetails
ASER2

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS57
ALYS143
ALYS148
ALYS152

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER129

222415

PDB entries from 2024-07-10

PDB statisticsPDBj update infoContact PDBjnumon