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6PKW

Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C2 symmetry (pseudo C4 symmetry)

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005262molecular_functioncalcium channel activity
A0005509molecular_functioncalcium ion binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0016020cellular_componentmembrane
A0019722biological_processcalcium-mediated signaling
A0046872molecular_functionmetal ion binding
A0047631molecular_functionADP-ribose diphosphatase activity
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051289biological_processprotein homotetramerization
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0072570molecular_functionADP-D-ribose binding
A0072571molecular_functionmono-ADP-D-ribose binding
A0099094molecular_functionligand-gated monoatomic cation channel activity
A0099604molecular_functionligand-gated calcium channel activity
B0005216molecular_functionmonoatomic ion channel activity
B0005262molecular_functioncalcium channel activity
B0005509molecular_functioncalcium ion binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0016020cellular_componentmembrane
B0019722biological_processcalcium-mediated signaling
B0046872molecular_functionmetal ion binding
B0047631molecular_functionADP-ribose diphosphatase activity
B0051209biological_processrelease of sequestered calcium ion into cytosol
B0051289biological_processprotein homotetramerization
B0055085biological_processtransmembrane transport
B0070588biological_processcalcium ion transmembrane transport
B0072570molecular_functionADP-D-ribose binding
B0072571molecular_functionmono-ADP-D-ribose binding
B0099094molecular_functionligand-gated monoatomic cation channel activity
B0099604molecular_functionligand-gated calcium channel activity
C0005216molecular_functionmonoatomic ion channel activity
C0005262molecular_functioncalcium channel activity
C0005509molecular_functioncalcium ion binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0016020cellular_componentmembrane
C0019722biological_processcalcium-mediated signaling
C0046872molecular_functionmetal ion binding
C0047631molecular_functionADP-ribose diphosphatase activity
C0051209biological_processrelease of sequestered calcium ion into cytosol
C0051289biological_processprotein homotetramerization
C0055085biological_processtransmembrane transport
C0070588biological_processcalcium ion transmembrane transport
C0072570molecular_functionADP-D-ribose binding
C0072571molecular_functionmono-ADP-D-ribose binding
C0099094molecular_functionligand-gated monoatomic cation channel activity
C0099604molecular_functionligand-gated calcium channel activity
D0005216molecular_functionmonoatomic ion channel activity
D0005262molecular_functioncalcium channel activity
D0005509molecular_functioncalcium ion binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0016020cellular_componentmembrane
D0019722biological_processcalcium-mediated signaling
D0046872molecular_functionmetal ion binding
D0047631molecular_functionADP-ribose diphosphatase activity
D0051209biological_processrelease of sequestered calcium ion into cytosol
D0051289biological_processprotein homotetramerization
D0055085biological_processtransmembrane transport
D0070588biological_processcalcium ion transmembrane transport
D0072570molecular_functionADP-D-ribose binding
D0072571molecular_functionmono-ADP-D-ribose binding
D0099094molecular_functionligand-gated monoatomic cation channel activity
D0099604molecular_functionligand-gated calcium channel activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues116
DetailsINTRAMEM: INTRAMEM => ECO:0000269|PubMed:30250252
ChainResidueDetails
ALYS730-TYR742
AARG1092-ILE1109
CLYS730-TYR742
CARG1092-ILE1109
BLYS730-TYR742
BARG1092-ILE1109
DLYS730-TYR742
DARG1092-ILE1109

site_idSWS_FT_FI2
Number of Residues1968
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
ATHR743-LYS812
BTHR743-LYS812
BTYR862-ASP880
BSER931-ARG945
BASN1064-SER1091
DTHR743-LYS812
DTYR862-ASP880
DSER931-ARG945
DASN1064-SER1091
ATYR862-ASP880
ASER931-ARG945
AASN1064-SER1091
CTHR743-LYS812
CTYR862-ASP880
CSER931-ARG945
CASN1064-SER1091

site_idSWS_FT_FI3
Number of Residues520
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:30250252
ChainResidueDetails
APHE813-ILE833
CILE910-PHE930
CMET946-LEU972
CLEU1039-PHE1063
BPHE813-ILE833
BTRP841-LEU861
BLEU881-LEU901
BILE910-PHE930
BMET946-LEU972
BLEU1039-PHE1063
DPHE813-ILE833
ATRP841-LEU861
DTRP841-LEU861
DLEU881-LEU901
DILE910-PHE930
DMET946-LEU972
DLEU1039-PHE1063
ALEU881-LEU901
AILE910-PHE930
AMET946-LEU972
ALEU1039-PHE1063
CPHE813-ILE833
CTRP841-LEU861
CLEU881-LEU901

site_idSWS_FT_FI4
Number of Residues208
DetailsTOPO_DOM: Extracellular => ECO:0000305
ChainResidueDetails
AASP834-SER840
BGLN902-TYR909
BILE973-TRP981
BPHE1007-TRP1038
DASP834-SER840
DGLN902-TYR909
DILE973-TRP981
DPHE1007-TRP1038
AGLN902-TYR909
AILE973-TRP981
APHE1007-TRP1038
CASP834-SER840
CGLN902-TYR909
CILE973-TRP981
CPHE1007-TRP1038
BASP834-SER840

site_idSWS_FT_FI5
Number of Residues96
DetailsINTRAMEM: Pore-forming => ECO:0000269|PubMed:30250252
ChainResidueDetails
AILE982-LEU1006
CILE982-LEU1006
BILE982-LEU1006
DILE982-LEU1006

site_idSWS_FT_FI6
Number of Residues32
DetailsBINDING: BINDING => ECO:0000305|PubMed:30250252
ChainResidueDetails
ATYR271
CARG278
CGLY309
CARG334
CGLU857
CGLN860
CASN883
CGLU1088
BTYR271
BARG278
BGLY309
AARG278
BARG334
BGLU857
BGLN860
BASN883
BGLU1088
DTYR271
DARG278
DGLY309
DARG334
DGLU857
AGLY309
DGLN860
DASN883
DGLU1088
AARG334
AGLU857
AGLN860
AASN883
AGLU1088
CTYR271

site_idSWS_FT_FI7
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
ChainResidueDetails
AASN1015
CASN1015
BASN1015
DASN1015

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PDB entries from 2024-05-01

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