6PJ2

Crystal structure of HCV NS3/4A D168A protease in complex with P4-P5-4 (AJ-65)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016020	cellular_component	membrane
A	0019062	biological_process	virion attachment to host cell
A	0019087	biological_process	transformation of host cell by virus
A	0033644	cellular_component	host cell membrane
A	0044423	cellular_component	virion component
A	0046718	biological_process	symbiont entry into host cell
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 9201

Chain	Residue
A	CYS1097
A	CYS1099
A	CYS1145
A	HIS1149

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site_id	AC2
Number of Residues	24
Details	binding site for residue OM7 A 9202

Chain	Residue
A	VAL1078
A	ASP1081
A	LEU1135
A	LYS1136
A	GLY1137
A	SER1138
A	SER1139
A	PHE1154
A	ARG1155
A	ALA1156
A	ALA1157
A	VAL1158
A	SER1159
A	EDO9203
A	SO49207
A	HOH9362
A	HOH9366
A	HOH9367
A	HOH9384
A	GLN1041
A	PHE1043
A	TYR1056
A	HIS1057
A	GLY1058

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 9203

Chain	Residue
A	SER1122
A	ARG1155
A	ALA1168
A	OM79202
A	HOH9359

---

site_id	AC4
Number of Residues	3
Details	binding site for residue EDO A 9204

Chain	Residue
A	THR1040
A	GLN1041
A	ARG1062

---

site_id	AC5
Number of Residues	7
Details	binding site for residue EDO A 9205

Chain	Residue
A	THR1072
A	CYS1099
A	GLY1100
A	SER1101
A	HIS1110
A	SER1133
A	TYR1134

---

site_id	AC6
Number of Residues	4
Details	binding site for residue EDO A 9206

Chain	Residue
A	ARG1119
A	THR1177
A	THR1178
A	MET1179

---

site_id	AC7
Number of Residues	5
Details	binding site for residue SO4 A 9207

Chain	Residue
A	TYR1006
A	GLN1008
A	TYR1056
A	OM79202
A	HOH9363

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