6PJ0

Crystal structure of HCV NS3/4A D168A protease in complex with P4-5 (NR01-97)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016020	cellular_component	membrane
A	0019062	biological_process	virion attachment to host cell
A	0019087	biological_process	transformation of host cell by virus
A	0033644	cellular_component	host cell membrane
A	0044423	cellular_component	virion component
A	0046718	biological_process	symbiont entry into host cell
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	binding site for residue OMV A 1301

Chain	Residue
A	GLN1041
A	LYS1136
A	GLY1137
A	SER1138
A	SER1139
A	PHE1154
A	ARG1155
A	ALA1156
A	ALA1157
A	ALA1168
A	SO41306
A	PHE1043
A	HOH1401
A	HOH1432
A	HOH1451
A	HOH1452
A	TYR1056
A	HIS1057
A	GLY1058
A	VAL1078
A	ASP1081
A	ARG1123
A	LEU1135

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1302

Chain	Residue
A	CYS1097
A	CYS1099
A	CYS1145
A	HIS1149

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site_id	AC3
Number of Residues	2
Details	binding site for residue EDO A 1303

Chain	Residue
A	SER1122
A	ARG1123

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site_id	AC4
Number of Residues	3
Details	binding site for residue EDO A 1304

Chain	Residue
A	THR1040
A	GLN1041
A	ARG1062

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site_id	AC5
Number of Residues	2
Details	binding site for residue EDO A 1305

Chain	Residue
A	GLU1176
A	HOH1498

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site_id	AC6
Number of Residues	5
Details	binding site for residue SO4 A 1306

Chain	Residue
A	TYR1006
A	GLN1008
A	TYR1056
A	OMV1301
A	HOH1410

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