6PIY
Crystal structure of HCV NS3/4A D168A protease in complex with P4-2 (NR02-61)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003724 | molecular_function | RNA helicase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019062 | biological_process | virion attachment to host cell |
| A | 0019087 | biological_process | symbiont-mediated transformation of host cell |
| A | 0033644 | cellular_component | host cell membrane |
| A | 0039502 | biological_process | symbiont-mediated suppression of host type I interferon-mediated signaling pathway |
| A | 0039545 | biological_process | symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity |
| A | 0043657 | cellular_component | host cell |
| A | 0046718 | biological_process | symbiont entry into host cell |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052031 | biological_process | symbiont-mediated perturbation of host defense response |
| A | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
| A | 0055036 | cellular_component | virion membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue OMS A 1201 |
| Chain | Residue |
| A | GLN1041 |
| A | GLY1137 |
| A | SER1138 |
| A | SER1139 |
| A | PHE1154 |
| A | ARG1155 |
| A | ALA1156 |
| A | ALA1157 |
| A | SO41207 |
| A | SO41208 |
| A | HOH1349 |
| A | PHE1043 |
| A | HOH1373 |
| A | HOH1384 |
| A | HOH1385 |
| A | HOH1386 |
| A | HOH1395 |
| A | TYR1056 |
| A | HIS1057 |
| A | VAL1078 |
| A | ASP1081 |
| A | ARG1123 |
| A | LEU1135 |
| A | LYS1136 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1202 |
| Chain | Residue |
| A | CYS1097 |
| A | CYS1099 |
| A | CYS1145 |
| A | HIS1149 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1203 |
| Chain | Residue |
| A | LYS989 |
| A | THR1040 |
| A | GLN1041 |
| A | ARG1062 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1204 |
| Chain | Residue |
| A | ASN1049 |
| A | GLY1050 |
| A | ASP1121 |
| A | SER1122 |
| A | ARG1123 |
| A | SO41208 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1205 |
| Chain | Residue |
| A | VAL1113 |
| A | PRO1115 |
| A | ARG1130 |
| A | HOH1379 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1206 |
| Chain | Residue |
| A | ARG1161 |
| A | HOH1310 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 1207 |
| Chain | Residue |
| A | TYR1006 |
| A | GLN1008 |
| A | TYR1056 |
| A | OMS1201 |
| A | HOH1306 |
| A | HOH1336 |
| A | HOH1346 |
| A | HOH1359 |
| A | HOH1405 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 1208 |
| Chain | Residue |
| A | SER1122 |
| A | ARG1123 |
| A | ARG1155 |
| A | ALA1168 |
| A | OMS1201 |
| A | EDO1204 |
| A | HOH1349 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 1209 |
| Chain | Residue |
| A | THR1072 |
| A | ARG1109 |
| A | HIS1110 |
| A | HOH1312 |
| A | HOH1358 |
| A | HOH1404 |
