6PIW

Crystal structure of HCV NS3/4A D168A protease in complex with P4-6 (NR03-67)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016020	cellular_component	membrane
A	0019062	biological_process	virion attachment to host cell
A	0019087	biological_process	transformation of host cell by virus
A	0033644	cellular_component	host cell membrane
A	0044423	cellular_component	virion component
A	0046718	biological_process	symbiont entry into host cell
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1201

Chain	Residue
A	CYS1097
A	CYS1099
A	CYS1145
A	HIS1149

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site_id	AC2
Number of Residues	23
Details	binding site for residue OLV A 1202

Chain	Residue
A	HIS1057
A	VAL1078
A	ASP1081
A	LEU1135
A	LYS1136
A	GLY1137
A	SER1138
A	SER1139
A	PHE1154
A	ARG1155
A	ALA1156
A	ALA1157
A	EDO1206
A	HOH1350
A	HOH1356
A	HOH1372
A	HOH1394
A	HOH1396
A	HIS982
A	GLN1041
A	THR1042
A	PHE1043
A	TYR1056

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 1203

Chain	Residue
A	ALA1087
A	SER1091
A	ARG1092
A	SER1093
A	ASP1121

---

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 1204

Chain	Residue
A	LYS989
A	THR1040
A	GLN1041
A	ARG1062

---

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 1205

Chain	Residue
A	GLN1008
A	TYR1056
A	HOH1334
A	HOH1343
A	HOH1378

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 1206

Chain	Residue
A	SER1122
A	ARG1123
A	ARG1155
A	ALA1168
A	OLV1202

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