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6PGO

Crystal structure of human KRAS G12C covalently bound to a phthalazine inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0007165biological_processsignal transduction
A0016020cellular_componentmembrane
B0003924molecular_functionGTPase activity
B0005525molecular_functionGTP binding
B0007165biological_processsignal transduction
B0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue MG A 301
ChainResidue
ASER17
AGDP302
AHOH405
AHOH408
AHOH409
AHOH436

site_idAC2
Number of Residues27
Detailsbinding site for residue GDP A 302
ChainResidue
ALYS16
ASER17
AALA18
APHE28
AASP30
AASP30
AGLU31
AGLU31
ATYR32
AASN116
ALYS117
AASP119
ALEU120
ASER145
AALA146
ALYS147
AMG301
AOJ1303
AHOH408
AHOH416
AHOH421
AHOH426
AHOH436
AHOH456
AGLY13
AVAL14
AGLY15

site_idAC3
Number of Residues18
Detailsbinding site for residue OJ1 A 303
ChainResidue
AVAL9
AGLY10
ACYS12
ALYS16
APRO34
AALA59
AGLY60
AARG68
AMET72
ATYR96
AGLN99
AILE100
ATHR148
AARG149
AGDP302
AHOH406
AHOH419
AHOH436

site_idAC4
Number of Residues6
Detailsbinding site for residue MG B 301
ChainResidue
BSER17
BGDP302
BHOH438
BHOH439
BHOH444
BHOH468

site_idAC5
Number of Residues24
Detailsbinding site for residue GDP B 302
ChainResidue
BGLY13
BVAL14
BGLY15
BLYS16
BSER17
BALA18
BPHE28
BVAL29
BASP30
BGLU31
BASN116
BLYS117
BASP119
BLEU120
BSER145
BALA146
BLYS147
BMG301
BHOH437
BHOH438
BHOH439
BHOH444
BHOH446
BHOH450

site_idAC6
Number of Residues14
Detailsbinding site for Di-peptide OJ1 B 303 and CYS B 12
ChainResidue
ALYS5
ALEU6
AVAL7
AGLU37
AASP38
ASER39
AASP54
ALEU56
ATYR71
ATHR74
BALA11
BGLY13
BVAL14
BHOH447

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140
ChainResidueDetails
AGLY10
AVAL29
AALA59
AASN116
BGLY10
BVAL29
BALA59
BASN116

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N-acetylmethionine; in GTPase KRas; alternate => ECO:0000269|Ref.17
ChainResidueDetails
AMET1
BMET1

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N-acetylthreonine; in GTPase KRas, N-terminally processed => ECO:0000269|Ref.17
ChainResidueDetails
ATHR2
BTHR2

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:22711838
ChainResidueDetails
ALYS104
BLYS104

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486
ChainResidueDetails
ATHR35
BTHR35

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PDB entries from 2024-07-17

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