6PGI
Asymmetric functions of a binuclear metal cluster within the transport pathway of the ZIP transition metal transporters
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005385 | molecular_function | zinc ion transmembrane transporter activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006829 | biological_process | zinc ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0030001 | biological_process | metal ion transport |
| A | 0046873 | molecular_function | metal ion transmembrane transporter activity |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0071577 | biological_process | zinc ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue CD A 401 |
| Chain | Residue |
| A | LEU224 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CD A 402 |
| Chain | Residue |
| A | MET99 |
| A | HIS177 |
| A | GLU181 |
| A | GLN207 |
| A | GLU211 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 201 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"28875161","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"28875161","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"28875161","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"M7 metal binding site","evidences":[{"source":"PubMed","id":"28875161","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TSA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"M1 metal binding site","evidences":[{"source":"PubMed","id":"28875161","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31914589","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35857505","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TSB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PGI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Z6M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"M6 metal binding site","evidences":[{"source":"PubMed","id":"28875161","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TSA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"M5 metal binding site","evidences":[{"source":"PubMed","id":"28875161","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TSA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | Binding site: {"description":"M2 metal binding site","evidences":[{"source":"PubMed","id":"28875161","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TSA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TSB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | Binding site: {"description":"M1 metal binding site","evidences":[{"source":"PubMed","id":"28875161","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TSA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"M3 metal binding site","evidences":[{"source":"PubMed","id":"28875161","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TSA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
