Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6PG8

WDR5delta23 bound to (2-(3-phenylpropyl)-1H-imidazol-4-yl)methanol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000123	cellular_component	histone acetyltransferase complex
A	0001501	biological_process	skeletal system development
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0006094	biological_process	gluconeogenesis
A	0006325	biological_process	chromatin organization
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0035097	cellular_component	histone methyltransferase complex
A	0042393	molecular_function	histone binding
A	0042800	molecular_function	histone H3K4 methyltransferase activity
A	0044545	cellular_component	NSL complex
A	0044665	cellular_component	MLL1/2 complex
A	0044666	cellular_component	MLL3/4 complex
A	0045722	biological_process	positive regulation of gluconeogenesis
A	0045815	biological_process	transcription initiation-coupled chromatin remodeling
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045995	biological_process	regulation of embryonic development
A	0048188	cellular_component	Set1C/COMPASS complex
A	0051302	biological_process	regulation of cell division
A	0051726	biological_process	regulation of cell cycle
A	0071339	cellular_component	MLL1 complex
A	0072686	cellular_component	mitotic spindle
A	0140004	molecular_function	histone H3Q5ser reader activity
A	0140109	molecular_function	histone H3K4me1 reader activity
A	0140672	cellular_component	ATAC complex
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000123	cellular_component	histone acetyltransferase complex
B	0001501	biological_process	skeletal system development
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0006094	biological_process	gluconeogenesis
B	0006325	biological_process	chromatin organization
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0035097	cellular_component	histone methyltransferase complex
B	0042393	molecular_function	histone binding
B	0042800	molecular_function	histone H3K4 methyltransferase activity
B	0044545	cellular_component	NSL complex
B	0044665	cellular_component	MLL1/2 complex
B	0044666	cellular_component	MLL3/4 complex
B	0045722	biological_process	positive regulation of gluconeogenesis
B	0045815	biological_process	transcription initiation-coupled chromatin remodeling
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0045995	biological_process	regulation of embryonic development
B	0048188	cellular_component	Set1C/COMPASS complex
B	0051302	biological_process	regulation of cell division
B	0051726	biological_process	regulation of cell cycle
B	0071339	cellular_component	MLL1 complex
B	0072686	cellular_component	mitotic spindle
B	0140004	molecular_function	histone H3Q5ser reader activity
B	0140109	molecular_function	histone H3K4me1 reader activity
B	0140672	cellular_component	ATAC complex
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000123	cellular_component	histone acetyltransferase complex
C	0001501	biological_process	skeletal system development
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0006094	biological_process	gluconeogenesis
C	0006325	biological_process	chromatin organization
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0035097	cellular_component	histone methyltransferase complex
C	0042393	molecular_function	histone binding
C	0042800	molecular_function	histone H3K4 methyltransferase activity
C	0044545	cellular_component	NSL complex
C	0044665	cellular_component	MLL1/2 complex
C	0044666	cellular_component	MLL3/4 complex
C	0045722	biological_process	positive regulation of gluconeogenesis
C	0045815	biological_process	transcription initiation-coupled chromatin remodeling
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0045995	biological_process	regulation of embryonic development
C	0048188	cellular_component	Set1C/COMPASS complex
C	0051302	biological_process	regulation of cell division
C	0051726	biological_process	regulation of cell cycle
C	0071339	cellular_component	MLL1 complex
C	0072686	cellular_component	mitotic spindle
C	0140004	molecular_function	histone H3Q5ser reader activity
C	0140109	molecular_function	histone H3K4me1 reader activity
C	0140672	cellular_component	ATAC complex
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000123	cellular_component	histone acetyltransferase complex
D	0001501	biological_process	skeletal system development
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0006094	biological_process	gluconeogenesis
D	0006325	biological_process	chromatin organization
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0035097	cellular_component	histone methyltransferase complex
D	0042393	molecular_function	histone binding
D	0042800	molecular_function	histone H3K4 methyltransferase activity
D	0044545	cellular_component	NSL complex
D	0044665	cellular_component	MLL1/2 complex
D	0044666	cellular_component	MLL3/4 complex
D	0045722	biological_process	positive regulation of gluconeogenesis
D	0045815	biological_process	transcription initiation-coupled chromatin remodeling
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0045995	biological_process	regulation of embryonic development
D	0048188	cellular_component	Set1C/COMPASS complex
D	0051302	biological_process	regulation of cell division
D	0051726	biological_process	regulation of cell cycle
D	0071339	cellular_component	MLL1 complex
D	0072686	cellular_component	mitotic spindle
D	0140004	molecular_function	histone H3Q5ser reader activity
D	0140109	molecular_function	histone H3K4me1 reader activity
D	0140672	cellular_component	ATAC complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue OGY A 401

Chain	Residue
A	SER49
A	SER91
A	PHE133
A	SER175
A	ALA176
A	PHE219
A	CYS261
A	PHE263
A	HOH674

site_id	AC2
Number of Residues	1
Details	binding site for residue CL A 402

Chain	Residue
A	LYS221

site_id	AC3
Number of Residues	9
Details	binding site for residue OGY B 401

Chain	Residue
B	SER49
B	SER91
B	PHE133
B	SER175
B	ALA176
B	PHE219
B	CYS261
B	PHE263
B	HOH674

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 B 402

Chain	Residue
B	ARG181
B	ASN225
D	SER117

site_id	AC5
Number of Residues	9
Details	binding site for residue OGY C 401

Chain	Residue
C	SER49
C	SER91
C	PHE133
C	SER175
C	ALA176
C	PHE219
C	CYS261
C	PHE263
C	HOH610

site_id	AC6
Number of Residues	1
Details	binding site for residue CL C 402

Chain	Residue
C	THR124

site_id	AC7
Number of Residues	10
Details	binding site for residue OGY D 401

Chain	Residue
D	SER49
D	ALA65
D	SER91
D	PHE133
D	SER175
D	ALA176
D	PHE219
D	CYS261
D	PHE263
D	HOH629

site_id	AC8
Number of Residues	2
Details	binding site for residue CL D 402

Chain	Residue
D	ASN265
D	CYS309

site_id	AC9
Number of Residues	1
Details	binding site for residue CL D 403

Chain	Residue
D	THR124

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV

Chain	Residue	Details
A	LEU102-VAL116
A	ILE144-VAL158
A	ILE186-THR200
A	ILE274-LEU288

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	156
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	164
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	160
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	156
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	160
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	136
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	16
Details	Site: {"description":"Important for interaction with histone H3"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	9
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	82
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)