6PE9
Crystal Structure of CD40 complexed to FAB516
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| G | 0009897 | cellular_component | external side of plasma membrane |
| G | 0038023 | molecular_function | signaling receptor activity |
| G | 0042113 | biological_process | B cell activation |
| G | 0050776 | biological_process | regulation of immune response |
| I | 0009897 | cellular_component | external side of plasma membrane |
| I | 0038023 | molecular_function | signaling receptor activity |
| I | 0042113 | biological_process | B cell activation |
| I | 0050776 | biological_process | regulation of immune response |
| J | 0009897 | cellular_component | external side of plasma membrane |
| J | 0038023 | molecular_function | signaling receptor activity |
| J | 0042113 | biological_process | B cell activation |
| J | 0050776 | biological_process | regulation of immune response |
| U | 0009897 | cellular_component | external side of plasma membrane |
| U | 0038023 | molecular_function | signaling receptor activity |
| U | 0042113 | biological_process | B cell activation |
| U | 0050776 | biological_process | regulation of immune response |
| V | 0009897 | cellular_component | external side of plasma membrane |
| V | 0038023 | molecular_function | signaling receptor activity |
| V | 0042113 | biological_process | B cell activation |
| V | 0050776 | biological_process | regulation of immune response |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 301 |
| Chain | Residue |
| A | THR110 |
| A | THR111 |
| A | LYS204 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 H 301 |
| Chain | Residue |
| H | THR110 |
| H | THR111 |
| H | LYS204 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 H 302 |
| Chain | Residue |
| H | LEU181 |
| H | SER182 |
| L | SER182 |
| L | THR184 |
| H | LEU144 |
| H | VAL172 |
| H | SER180 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 I 201 |
| Chain | Residue |
| I | THR70 |
| I | TRP71 |
| U | THR70 |
| U | TRP71 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 L 401 |
| Chain | Residue |
| L | GLN43 |
| L | LYS45 |
| L | GLN48 |
| L | LYS51 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
| Chain | Residue | Details |
| A | TYR197-HIS203 | |
| B | TYR198-HIS204 |
| site_id | PS00652 |
| Number of Residues | 34 |
| Details | TNFR_NGFR_1 TNFR/NGFR family cysteine-rich region signature. Crekq..Ylinsq.....C..Csl.Cqpgqklvsd..Cteft..ETEC |
| Chain | Residue | Details |
| G | CYS26-CYS59 |
| site_id | PS01186 |
| Number of Residues | 14 |
| Details | EGF_2 EGF-like domain signature 2. CtCeeGWhctsea..C |
| Chain | Residue | Details |
| G | CYS103-CYS116 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 860 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| G | GLU21-ARG193 | |
| I | GLU21-ARG193 | |
| J | GLU21-ARG193 | |
| U | GLU21-ARG193 | |
| V | GLU21-ARG193 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| G | ASN153 | |
| V | ASN180 | |
| G | ASN180 | |
| I | ASN153 | |
| I | ASN180 | |
| J | ASN153 | |
| J | ASN180 | |
| U | ASN153 | |
| U | ASN180 | |
| V | ASN153 |
