6PE4

Yeast Vo motor in complex with 1 VopQ molecule

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
A	0000324	cellular_component	fungal-type vacuole
A	0000329	cellular_component	fungal-type vacuole membrane
A	0005515	molecular_function	protein binding
A	0005773	cellular_component	vacuole
A	0005774	cellular_component	vacuolar membrane
A	0006797	biological_process	polyphosphate metabolic process
A	0007035	biological_process	vacuolar acidification
A	0016020	cellular_component	membrane
A	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
A	0019865	molecular_function	immunoglobulin binding
A	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
A	0045121	cellular_component	membrane raft
A	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
A	0051117	molecular_function	ATPase binding
A	0065003	biological_process	protein-containing complex assembly
A	0071469	biological_process	cellular response to alkaline pH
A	0071474	biological_process	cellular hyperosmotic response
A	0080025	molecular_function	phosphatidylinositol-3,5-bisphosphate binding
A	1902600	biological_process	proton transmembrane transport
A	1903778	biological_process	protein localization to vacuolar membrane
D	0000139	cellular_component	Golgi membrane
D	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
D	0000329	cellular_component	fungal-type vacuole membrane
D	0005515	molecular_function	protein binding
D	0005773	cellular_component	vacuole
D	0005774	cellular_component	vacuolar membrane
D	0007034	biological_process	vacuolar transport
D	0007035	biological_process	vacuolar acidification
D	0016020	cellular_component	membrane
D	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
D	0033176	cellular_component	proton-transporting V-type ATPase complex
D	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	0048388	biological_process	endosomal lumen acidification
D	0061795	biological_process	Golgi lumen acidification
D	1902600	biological_process	proton transmembrane transport
E	0000032	biological_process	cell wall mannoprotein biosynthetic process
E	0000139	cellular_component	Golgi membrane
E	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
E	0000329	cellular_component	fungal-type vacuole membrane
E	0005773	cellular_component	vacuole
E	0005774	cellular_component	vacuolar membrane
E	0007035	biological_process	vacuolar acidification
E	0016020	cellular_component	membrane
E	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
E	0033176	cellular_component	proton-transporting V-type ATPase complex
E	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
E	0042625	molecular_function	ATPase-coupled ion transmembrane transporter activity
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	0048388	biological_process	endosomal lumen acidification
E	0055085	biological_process	transmembrane transport
E	0061795	biological_process	Golgi lumen acidification
E	0065003	biological_process	protein-containing complex assembly
E	1902600	biological_process	proton transmembrane transport
F	0000139	cellular_component	Golgi membrane
F	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
F	0000329	cellular_component	fungal-type vacuole membrane
F	0003674	molecular_function	molecular_function
F	0004521	molecular_function	RNA endonuclease activity
F	0005575	cellular_component	cellular_component
F	0005773	cellular_component	vacuole
F	0005774	cellular_component	vacuolar membrane
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0007035	biological_process	vacuolar acidification
F	0008150	biological_process	biological_process
F	0016020	cellular_component	membrane
F	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
F	0033176	cellular_component	proton-transporting V-type ATPase complex
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	0048388	biological_process	endosomal lumen acidification
F	0061795	biological_process	Golgi lumen acidification
F	0090304	biological_process	nucleic acid metabolic process
F	1902600	biological_process	proton transmembrane transport
G	0000139	cellular_component	Golgi membrane
G	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
G	0000329	cellular_component	fungal-type vacuole membrane
G	0005773	cellular_component	vacuole
G	0005774	cellular_component	vacuolar membrane
G	0007035	biological_process	vacuolar acidification
G	0008553	molecular_function	P-type proton-exporting transporter activity
G	0015078	molecular_function	proton transmembrane transporter activity
G	0016020	cellular_component	membrane
G	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
G	0033176	cellular_component	proton-transporting V-type ATPase complex
G	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
G	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
G	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
G	0048388	biological_process	endosomal lumen acidification
G	0061795	biological_process	Golgi lumen acidification
G	1902600	biological_process	proton transmembrane transport
H	0000139	cellular_component	Golgi membrane
H	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
H	0000324	cellular_component	fungal-type vacuole
H	0000329	cellular_component	fungal-type vacuole membrane
H	0005773	cellular_component	vacuole
H	0005774	cellular_component	vacuolar membrane
H	0007035	biological_process	vacuolar acidification
H	0015078	molecular_function	proton transmembrane transporter activity
H	0016020	cellular_component	membrane
H	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
H	0033176	cellular_component	proton-transporting V-type ATPase complex
H	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
H	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
H	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
H	0048388	biological_process	endosomal lumen acidification
H	0061795	biological_process	Golgi lumen acidification
H	0071944	cellular_component	cell periphery
H	1902600	biological_process	proton transmembrane transport
I	0000139	cellular_component	Golgi membrane
I	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
I	0000329	cellular_component	fungal-type vacuole membrane
I	0005773	cellular_component	vacuole
I	0005774	cellular_component	vacuolar membrane
I	0006623	biological_process	protein targeting to vacuole
I	0006878	biological_process	intracellular copper ion homeostasis
I	0006879	biological_process	intracellular iron ion homeostasis
I	0006897	biological_process	endocytosis
I	0007033	biological_process	vacuole organization
I	0007035	biological_process	vacuolar acidification
I	0015078	molecular_function	proton transmembrane transporter activity
I	0016020	cellular_component	membrane
I	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
I	0033176	cellular_component	proton-transporting V-type ATPase complex
I	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
I	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
I	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
I	0048388	biological_process	endosomal lumen acidification
I	0061795	biological_process	Golgi lumen acidification
I	1902600	biological_process	proton transmembrane transport
J	0000139	cellular_component	Golgi membrane
J	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
J	0000329	cellular_component	fungal-type vacuole membrane
J	0005773	cellular_component	vacuole
J	0005774	cellular_component	vacuolar membrane
J	0006623	biological_process	protein targeting to vacuole
J	0006878	biological_process	intracellular copper ion homeostasis
J	0006879	biological_process	intracellular iron ion homeostasis
J	0006897	biological_process	endocytosis
J	0007033	biological_process	vacuole organization
J	0007035	biological_process	vacuolar acidification
J	0015078	molecular_function	proton transmembrane transporter activity
J	0016020	cellular_component	membrane
J	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
J	0033176	cellular_component	proton-transporting V-type ATPase complex
J	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
J	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
J	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
J	0048388	biological_process	endosomal lumen acidification
J	0061795	biological_process	Golgi lumen acidification
J	1902600	biological_process	proton transmembrane transport
K	0000139	cellular_component	Golgi membrane
K	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
K	0000329	cellular_component	fungal-type vacuole membrane
K	0005773	cellular_component	vacuole
K	0005774	cellular_component	vacuolar membrane
K	0006623	biological_process	protein targeting to vacuole
K	0006878	biological_process	intracellular copper ion homeostasis
K	0006879	biological_process	intracellular iron ion homeostasis
K	0006897	biological_process	endocytosis
K	0007033	biological_process	vacuole organization
K	0007035	biological_process	vacuolar acidification
K	0015078	molecular_function	proton transmembrane transporter activity
K	0016020	cellular_component	membrane
K	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
K	0033176	cellular_component	proton-transporting V-type ATPase complex
K	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
K	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
K	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
K	0048388	biological_process	endosomal lumen acidification
K	0061795	biological_process	Golgi lumen acidification
K	1902600	biological_process	proton transmembrane transport
L	0000139	cellular_component	Golgi membrane
L	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
L	0000329	cellular_component	fungal-type vacuole membrane
L	0005773	cellular_component	vacuole
L	0005774	cellular_component	vacuolar membrane
L	0006623	biological_process	protein targeting to vacuole
L	0006878	biological_process	intracellular copper ion homeostasis
L	0006879	biological_process	intracellular iron ion homeostasis
L	0006897	biological_process	endocytosis
L	0007033	biological_process	vacuole organization
L	0007035	biological_process	vacuolar acidification
L	0015078	molecular_function	proton transmembrane transporter activity
L	0016020	cellular_component	membrane
L	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
L	0033176	cellular_component	proton-transporting V-type ATPase complex
L	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
L	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
L	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
L	0048388	biological_process	endosomal lumen acidification
L	0061795	biological_process	Golgi lumen acidification
L	1902600	biological_process	proton transmembrane transport
M	0000139	cellular_component	Golgi membrane
M	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
M	0000329	cellular_component	fungal-type vacuole membrane
M	0005773	cellular_component	vacuole
M	0005774	cellular_component	vacuolar membrane
M	0006623	biological_process	protein targeting to vacuole
M	0006878	biological_process	intracellular copper ion homeostasis
M	0006879	biological_process	intracellular iron ion homeostasis
M	0006897	biological_process	endocytosis
M	0007033	biological_process	vacuole organization
M	0007035	biological_process	vacuolar acidification
M	0015078	molecular_function	proton transmembrane transporter activity
M	0016020	cellular_component	membrane
M	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
M	0033176	cellular_component	proton-transporting V-type ATPase complex
M	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
M	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
M	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
M	0048388	biological_process	endosomal lumen acidification
M	0061795	biological_process	Golgi lumen acidification
M	1902600	biological_process	proton transmembrane transport
N	0000139	cellular_component	Golgi membrane
N	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
N	0000329	cellular_component	fungal-type vacuole membrane
N	0005773	cellular_component	vacuole
N	0005774	cellular_component	vacuolar membrane
N	0006623	biological_process	protein targeting to vacuole
N	0006878	biological_process	intracellular copper ion homeostasis
N	0006879	biological_process	intracellular iron ion homeostasis
N	0006897	biological_process	endocytosis
N	0007033	biological_process	vacuole organization
N	0007035	biological_process	vacuolar acidification
N	0015078	molecular_function	proton transmembrane transporter activity
N	0016020	cellular_component	membrane
N	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
N	0033176	cellular_component	proton-transporting V-type ATPase complex
N	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
N	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
N	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
N	0048388	biological_process	endosomal lumen acidification
N	0061795	biological_process	Golgi lumen acidification
N	1902600	biological_process	proton transmembrane transport
O	0000139	cellular_component	Golgi membrane
O	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
O	0000329	cellular_component	fungal-type vacuole membrane
O	0005773	cellular_component	vacuole
O	0005774	cellular_component	vacuolar membrane
O	0006623	biological_process	protein targeting to vacuole
O	0006878	biological_process	intracellular copper ion homeostasis
O	0006879	biological_process	intracellular iron ion homeostasis
O	0006897	biological_process	endocytosis
O	0007033	biological_process	vacuole organization
O	0007035	biological_process	vacuolar acidification
O	0015078	molecular_function	proton transmembrane transporter activity
O	0016020	cellular_component	membrane
O	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
O	0033176	cellular_component	proton-transporting V-type ATPase complex
O	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
O	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
O	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
O	0048388	biological_process	endosomal lumen acidification
O	0061795	biological_process	Golgi lumen acidification
O	1902600	biological_process	proton transmembrane transport
P	0000139	cellular_component	Golgi membrane
P	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
P	0000329	cellular_component	fungal-type vacuole membrane
P	0005773	cellular_component	vacuole
P	0005774	cellular_component	vacuolar membrane
P	0006623	biological_process	protein targeting to vacuole
P	0006878	biological_process	intracellular copper ion homeostasis
P	0006879	biological_process	intracellular iron ion homeostasis
P	0006897	biological_process	endocytosis
P	0007033	biological_process	vacuole organization
P	0007035	biological_process	vacuolar acidification
P	0015078	molecular_function	proton transmembrane transporter activity
P	0016020	cellular_component	membrane
P	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
P	0033176	cellular_component	proton-transporting V-type ATPase complex
P	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
P	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
P	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
P	0048388	biological_process	endosomal lumen acidification
P	0061795	biological_process	Golgi lumen acidification
P	1902600	biological_process	proton transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	248
Details	TOPO_DOM: Vacuolar => ECO:0000255

Chain	Residue	Details
I	MET1-TYR8
L	MET1-TYR8
L	CYS75-GLN90
L	ASN151-CYS160
M	MET1-TYR8
M	CYS75-GLN90
M	ASN151-CYS160
N	MET1-TYR8
N	CYS75-GLN90
N	ASN151-CYS160
O	MET1-TYR8
I	CYS75-GLN90
O	CYS75-GLN90
O	ASN151-CYS160
P	MET1-TYR8
P	CYS75-GLN90
P	ASN151-CYS160
I	ASN151-CYS160
J	MET1-TYR8
J	CYS75-GLN90
J	ASN151-CYS160
K	MET1-TYR8
K	CYS75-GLN90
K	ASN151-CYS160

---

site_id	SWS_FT_FI2
Number of Residues	704
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
I	ALA9-GLY31
K	ILE54-VAL74
K	LEU91-GLY112
K	LEU125-LEU150
L	ALA9-GLY31
L	ILE54-VAL74
L	LEU91-GLY112
L	LEU125-LEU150
M	ALA9-GLY31
M	ILE54-VAL74
M	LEU91-GLY112
I	ILE54-VAL74
M	LEU125-LEU150
N	ALA9-GLY31
N	ILE54-VAL74
N	LEU91-GLY112
N	LEU125-LEU150
O	ALA9-GLY31
O	ILE54-VAL74
O	LEU91-GLY112
O	LEU125-LEU150
P	ALA9-GLY31
I	LEU91-GLY112
P	ILE54-VAL74
P	LEU91-GLY112
P	LEU125-LEU150
I	LEU125-LEU150
J	ALA9-GLY31
J	ILE54-VAL74
J	LEU91-GLY112
J	LEU125-LEU150
K	ALA9-GLY31

---

site_id	SWS_FT_FI3
Number of Residues	256
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
I	THR32-ASN53
M	ASP113-ARG124
N	THR32-ASN53
N	ASP113-ARG124
O	THR32-ASN53
O	ASP113-ARG124
P	THR32-ASN53
P	ASP113-ARG124
I	ASP113-ARG124
J	THR32-ASN53
J	ASP113-ARG124
K	THR32-ASN53
K	ASP113-ARG124
L	THR32-ASN53
L	ASP113-ARG124
M	THR32-ASN53

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	SITE: Essential for proton translocation => ECO:0000269|PubMed:1825730

Chain	Residue	Details
I	GLU137
J	GLU137
K	GLU137
L	GLU137
M	GLU137
N	GLU137
O	GLU137
P	GLU137

---