6PCB
Crystal structure of beta-ketoadipyl-CoA thiolase mutant (H356A) in complex with COA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0019619 | biological_process | 3,4-dihydroxybenzoate catabolic process |
| A | 0033812 | molecular_function | 3-oxoadipyl-CoA thiolase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0019619 | biological_process | 3,4-dihydroxybenzoate catabolic process |
| B | 0033812 | molecular_function | 3-oxoadipyl-CoA thiolase activity |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0019619 | biological_process | 3,4-dihydroxybenzoate catabolic process |
| C | 0033812 | molecular_function | 3-oxoadipyl-CoA thiolase activity |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| D | 0019619 | biological_process | 3,4-dihydroxybenzoate catabolic process |
| D | 0033812 | molecular_function | 3-oxoadipyl-CoA thiolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue COA A 1001 |
| Chain | Residue |
| A | CYS90 |
| A | PHE325 |
| A | ALA356 |
| A | LEU358 |
| A | HOH1105 |
| A | HOH1131 |
| A | HOH1178 |
| A | HOH1201 |
| A | HOH1244 |
| A | HOH1281 |
| A | HOH1297 |
| A | ILE145 |
| A | HOH1301 |
| A | HOH1327 |
| A | HOH1328 |
| A | ARG226 |
| A | THR229 |
| A | ALA249 |
| A | GLY250 |
| A | SER253 |
| A | GLY254 |
| A | ASN322 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 1002 |
| Chain | Residue |
| A | ARG187 |
| A | SER188 |
| A | LYS191 |
| A | GLU323 |
| A | VAL345 |
| A | ASN346 |
| A | GLY349 |
| A | HOH1106 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 1003 |
| Chain | Residue |
| A | ASN322 |
| A | ARG364 |
| A | LEU365 |
| A | HOH1228 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue GOL B 502 |
| Chain | Residue |
| B | ARG187 |
| B | SER188 |
| B | LYS191 |
| B | GLU323 |
| B | ASP340 |
| B | ASP341 |
| B | VAL345 |
| B | ASN346 |
| B | GLY349 |
| B | HOH610 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue CL B 503 |
| Chain | Residue |
| B | ARG65 |
| B | HOH745 |
| C | GLY146 |
| C | ARG148 |
| C | HOH882 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 502 |
| Chain | Residue |
| C | ARG187 |
| C | SER188 |
| C | LYS191 |
| C | GLU323 |
| C | VAL345 |
| C | ASN346 |
| C | GLY349 |
| C | HOH634 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue CL C 503 |
| Chain | Residue |
| C | MET120 |
| C | GLY254 |
| C | ALA356 |
| C | COA501 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 502 |
| Chain | Residue |
| D | PHE184 |
| D | ARG187 |
| D | SER188 |
| D | LYS191 |
| D | GLU323 |
| D | VAL345 |
| D | ASN346 |
| D | GLY349 |
| D | HOH645 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue CL D 503 |
| Chain | Residue |
| D | MET163 |
| D | HOH681 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue CL D 504 |
| Chain | Residue |
| A | GLY146 |
| A | ARG148 |
| D | ARG65 |
| D | HOH858 |
Functional Information from PROSITE/UniProt
