6PCA
Crystal structure of beta-ketoadipyl-CoA thiolase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003988 | molecular_function | acetyl-CoA C-acyltransferase activity |
| A | 0006635 | biological_process | fatty acid beta-oxidation |
| A | 0010124 | biological_process | phenylacetate catabolic process |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0019619 | biological_process | 3,4-dihydroxybenzoate catabolic process |
| A | 0033812 | molecular_function | 3-oxoadipyl-CoA thiolase activity |
| B | 0003988 | molecular_function | acetyl-CoA C-acyltransferase activity |
| B | 0006635 | biological_process | fatty acid beta-oxidation |
| B | 0010124 | biological_process | phenylacetate catabolic process |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0019619 | biological_process | 3,4-dihydroxybenzoate catabolic process |
| B | 0033812 | molecular_function | 3-oxoadipyl-CoA thiolase activity |
| C | 0003988 | molecular_function | acetyl-CoA C-acyltransferase activity |
| C | 0006635 | biological_process | fatty acid beta-oxidation |
| C | 0010124 | biological_process | phenylacetate catabolic process |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0019619 | biological_process | 3,4-dihydroxybenzoate catabolic process |
| C | 0033812 | molecular_function | 3-oxoadipyl-CoA thiolase activity |
| D | 0003988 | molecular_function | acetyl-CoA C-acyltransferase activity |
| D | 0006635 | biological_process | fatty acid beta-oxidation |
| D | 0010124 | biological_process | phenylacetate catabolic process |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| D | 0019619 | biological_process | 3,4-dihydroxybenzoate catabolic process |
| D | 0033812 | molecular_function | 3-oxoadipyl-CoA thiolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 501 |
| Chain | Residue |
| A | ARG187 |
| A | SER188 |
| A | LYS191 |
| A | GLU323 |
| A | VAL345 |
| A | ASN346 |
| A | GLY349 |
| A | HOH624 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | THR143 |
| A | THR144 |
| A | ARG148 |
| A | LEU358 |
| A | CL505 |
| A | HOH643 |
| D | ARG65 |
| A | ASN58 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 503 |
| Chain | Residue |
| A | GLY128 |
| A | LYS129 |
| D | GLU62 |
| D | ARG122 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 504 |
| Chain | Residue |
| A | ARG65 |
| D | GLY146 |
| D | GOL502 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 505 |
| Chain | Residue |
| A | GLY146 |
| A | GOL502 |
| D | ARG65 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 501 |
| Chain | Residue |
| B | ARG187 |
| B | SER188 |
| B | LYS191 |
| B | GLU323 |
| B | VAL345 |
| B | ASN346 |
| B | GLY349 |
| B | HOH620 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 502 |
| Chain | Residue |
| B | ASN58 |
| B | THR143 |
| B | THR144 |
| B | GLY146 |
| B | ARG148 |
| B | CL503 |
| B | HOH705 |
| C | ARG65 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 503 |
| Chain | Residue |
| B | GLY146 |
| B | GOL502 |
| C | ARG65 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 504 |
| Chain | Residue |
| B | ARG65 |
| C | GLY146 |
| C | GOL502 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue CL B 505 |
| Chain | Residue |
| B | PHE200 |
| B | GLU320 |
| B | ASN348 |
| B | THR368 |
| B | GLN372 |
| site_id | AD2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL C 501 |
| Chain | Residue |
| C | PHE184 |
| C | ARG187 |
| C | SER188 |
| C | LYS191 |
| C | GLU323 |
| C | VAL345 |
| C | ASN346 |
| C | GLY349 |
| C | HOH614 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 502 |
| Chain | Residue |
| B | ARG65 |
| B | CL504 |
| C | ASN58 |
| C | THR143 |
| C | THR144 |
| C | ARG148 |
| C | HOH619 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue ACT C 503 |
| Chain | Residue |
| B | GLU62 |
| B | ARG122 |
| C | GLY128 |
| C | LYS129 |
| C | HOH731 |
| site_id | AD5 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 501 |
| Chain | Residue |
| D | PHE184 |
| D | ARG187 |
| D | SER188 |
| D | LYS191 |
| D | GLU323 |
| D | VAL345 |
| D | ASN346 |
| D | GLY349 |
| D | HOH640 |
| site_id | AD6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL D 502 |
| Chain | Residue |
| A | ARG65 |
| A | CL504 |
| D | ASN58 |
| D | THR143 |
| D | THR144 |
| D | ARG148 |
| D | HOH610 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue ACT D 503 |
| Chain | Residue |
| A | GLU62 |
| A | ARG122 |
| D | GLY128 |
| D | LYS129 |
| D | GLU131 |
Functional Information from PROSITE/UniProt
| site_id | PS00098 |
| Number of Residues | 19 |
| Details | THIOLASE_1 Thiolases acyl-enzyme intermediate signature. LNRlCASGMdAVgtafraI |
| Chain | Residue | Details |
| A | LEU86-ILE104 |
| site_id | PS00099 |
| Number of Residues | 14 |
| Details | THIOLASE_3 Thiolases active site. GLATMCVGvGqGlA |
| Chain | Residue | Details |
| A | GLY381-ALA394 |
| site_id | PS00737 |
| Number of Residues | 17 |
| Details | THIOLASE_2 Thiolases signature 2. NpnGGaIAlGHPlGmSG |
| Chain | Residue | Details |
| A | ASN346-GLY362 |
