6PAS

Inactive State of Manduca sexta soluble guanylate cyclase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004383	molecular_function	guanylate cyclase activity
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0006182	biological_process	cGMP biosynthetic process
A	0008074	cellular_component	guanylate cyclase complex, soluble
A	0009190	biological_process	cyclic nucleotide biosynthetic process
A	0009975	molecular_function	cyclase activity
A	0016829	molecular_function	lyase activity
A	0016849	molecular_function	phosphorus-oxygen lyase activity
A	0019934	biological_process	cGMP-mediated signaling
A	0020037	molecular_function	heme binding
A	0035556	biological_process	intracellular signal transduction
A	0070482	biological_process	response to oxygen levels
B	0004383	molecular_function	guanylate cyclase activity
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0006182	biological_process	cGMP biosynthetic process
B	0009190	biological_process	cyclic nucleotide biosynthetic process
B	0009975	molecular_function	cyclase activity
B	0016829	molecular_function	lyase activity
B	0016849	molecular_function	phosphorus-oxygen lyase activity
B	0020037	molecular_function	heme binding
B	0035556	biological_process	intracellular signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue HEM B 701

Chain	Residue
B	MET1
B	TYR2
B	ARG116
B	SER117
B	PRO118

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Functional Information from PROSITE/UniProt

site_id	PS00452
Number of Residues	24
Details	GUANYLATE_CYCLASE_1 Guanylate cyclase signature. GVV.GktmlkYcLFGHNVTlankfE

Chain	Residue	Details
A	GLY586-GLU609
B	GLY522-GLU545

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