6P9C
OXA-48 carbapanemase, doripenem complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0008658 | molecular_function | penicillin binding |
A | 0008800 | molecular_function | beta-lactamase activity |
A | 0017001 | biological_process | antibiotic catabolic process |
B | 0008658 | molecular_function | penicillin binding |
B | 0008800 | molecular_function | beta-lactamase activity |
B | 0017001 | biological_process | antibiotic catabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 11 |
Details | binding site for residue 4J6 A 301 |
Chain | Residue |
A | ALA69 |
A | ARG250 |
A | HOH419 |
A | SER70 |
A | SER118 |
A | GLU132 |
A | LEU158 |
A | THR209 |
A | GLY210 |
A | TYR211 |
A | LEU247 |
site_id | AC2 |
Number of Residues | 9 |
Details | binding site for residue O6P A 302 |
Chain | Residue |
A | ASN48 |
A | LYS51 |
A | LEU228 |
A | ASP230 |
A | ASN231 |
A | TRP233 |
A | GLU261 |
A | LYS262 |
A | ILE263 |
site_id | AC3 |
Number of Residues | 2 |
Details | binding site for residue CL A 303 |
Chain | Residue |
A | LYS73 |
A | TRP157 |
site_id | AC4 |
Number of Residues | 2 |
Details | binding site for residue CL A 304 |
Chain | Residue |
A | ARG206 |
B | ARG206 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue CA A 305 |
Chain | Residue |
A | HIS34 |
A | GLU37 |
A | GLU256 |
A | CD307 |
site_id | AC6 |
Number of Residues | 1 |
Details | binding site for residue CA A 306 |
Chain | Residue |
A | ASP154 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue CD A 307 |
Chain | Residue |
A | GLU37 |
A | HIS38 |
A | GLU125 |
A | GLU256 |
A | CA305 |
site_id | AC8 |
Number of Residues | 12 |
Details | binding site for residue 4J6 B 301 |
Chain | Residue |
B | ALA69 |
B | SER70 |
B | SER118 |
B | LEU158 |
B | LYS208 |
B | THR209 |
B | GLY210 |
B | TYR211 |
B | SER244 |
B | LEU247 |
B | ARG250 |
B | HOH464 |
site_id | AC9 |
Number of Residues | 9 |
Details | binding site for residue O6P B 302 |
Chain | Residue |
B | ASN48 |
B | LYS51 |
B | LEU228 |
B | ASP230 |
B | ASN231 |
B | TRP233 |
B | GLU261 |
B | LYS262 |
B | ILE263 |
site_id | AD1 |
Number of Residues | 2 |
Details | binding site for residue CL B 303 |
Chain | Residue |
B | LYS73 |
B | TRP157 |
site_id | AD2 |
Number of Residues | 7 |
Details | binding site for residue CA B 305 |
Chain | Residue |
A | ASP143 |
A | GLU147 |
A | HOH413 |
B | ASP143 |
B | GLU147 |
B | HOH446 |
B | HOH452 |
site_id | AD3 |
Number of Residues | 7 |
Details | binding site for residue CD B 306 |
Chain | Residue |
A | GLU147 |
A | HOH486 |
B | ASP143 |
B | GLU147 |
B | HOH401 |
B | HOH404 |
B | HOH423 |
Functional Information from PROSITE/UniProt
site_id | PS00337 |
Number of Residues | 11 |
Details | BETA_LACTAMASE_D Beta-lactamase class-D active site. PaSTFKIPnSL |
Chain | Residue | Details |
A | PRO68-LEU78 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26731698","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31358584","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32150407","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V1O","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8RLA6","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P13661","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19477418","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3HBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |