Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| A | 0015936 | biological_process | coenzyme A metabolic process |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue ADP A 501 |
| Chain | Residue |
| A | ASP167 |
| A | THR210 |
| A | VAL349 |
| A | GLY350 |
| A | HOH606 |
| A | HOH611 |
| A | HOH614 |
| A | HOH623 |
| A | HOH629 |
| A | HOH635 |
| A | HOH710 |
| A | VAL169 |
| A | HOH872 |
| A | LEU173 |
| A | VAL202 |
| A | ARG203 |
| A | ASP204 |
| A | ALA205 |
| A | MET206 |
| A | GLY207 |
| site_id | AC2 |
| Number of Residues | 33 |
| Details | binding site for residue COA A 502 |
| Chain | Residue |
| A | ARG32 |
| A | GLU73 |
| A | ASN74 |
| A | TYR88 |
| A | GLU104 |
| A | SER106 |
| A | ALA109 |
| A | ALA110 |
| A | SER112 |
| A | TYR113 |
| A | LYS116 |
| A | GLY388 |
| A | ALA389 |
| A | ALA392 |
| A | HOH607 |
| A | HOH642 |
| A | HOH644 |
| A | HOH660 |
| A | HOH672 |
| A | HOH690 |
| A | HOH703 |
| A | HOH705 |
| A | HOH734 |
| A | HOH747 |
| A | HOH775 |
| A | HOH779 |
| A | HOH807 |
| A | HOH808 |
| A | HOH829 |
| A | HOH830 |
| A | HOH854 |
| A | HOH871 |
| A | HOH875 |
Functional Information from PROSITE/UniProt
| site_id | PS00066 |
| Number of Residues | 15 |
| Details | HMG_COA_REDUCTASE_1 Hydroxymethylglutaryl-coenzyme A reductases signature 1. HlIVdVRDaMGaNtV |
| Chain | Residue | Details |
| A | HIS197-VAL211 | |
| site_id | PS00318 |
| Number of Residues | 8 |
| Details | HMG_COA_REDUCTASE_2 Hydroxymethylglutaryl-coenzyme A reductases signature 2. VGlVGGAT |
| Chain | Residue | Details |
| A | VAL346-THR353 | |
| site_id | PS01192 |
| Number of Residues | 14 |
| Details | HMG_COA_REDUCTASE_3 Hydroxymethylglutaryl-coenzyme A reductases signature 3. ALaTegIqRGHMaL |
| Chain | Residue | Details |
| A | ALA392-LEU405 | |
