6P6T

HCV NS3/4A protease domain of genotype 4a in complex with glecaprevir

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
A	0019087	biological_process	transformation of host cell by virus

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1201

Chain	Residue
A	CYS1097
A	CYS1099
A	CYS1145
A	HOH1317

---

site_id	AC2
Number of Residues	28
Details	binding site for residue O31 A 1202

Chain	Residue
A	VAL1078
A	ASP1081
A	HIS1110
A	ALA1111
A	ASP1112
A	ARG1123
A	PRO1129
A	ARG1130
A	PRO1131
A	ILE1132
A	LEU1135
A	LYS1136
A	GLY1137
A	SER1138
A	SER1139
A	PHE1154
A	ARG1155
A	ALA1156
A	ALA1157
A	ASP1168
A	HOH1338
A	HOH1353
A	HOH1399
A	GLN1041
A	PHE1043
A	TYR1056
A	HIS1057
A	GLY1058

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166

Chain	Residue	Details
A	HIS1057
A	ASP1081
A	SER1139

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01166

Chain	Residue	Details
A	CYS1097
A	CYS1099
A	CYS1145
A	HIS1149

---