6P6R

HCV NS3/4A protease domain of genotype 1a3a chimera in complex with glecaprevir

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
A	0019087	biological_process	transformation of host cell by virus

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue EDO A 1201

Chain	Residue
A	LYS989
A	THR1040
A	GLN1041
A	ARG1062
A	HOH1310
A	HOH1315

---

site_id	AC2
Number of Residues	5
Details	binding site for residue EDO A 1202

Chain	Residue
A	HOH1331
A	HOH1340
A	THR1072
A	GLN1073
A	ARG1109

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 1203

Chain	Residue
A	CYS1097
A	CYS1099
A	CYS1145
A	HIS1149

---

site_id	AC4
Number of Residues	9
Details	binding site for residue SO4 A 1204

Chain	Residue
A	TYR1006
A	GLN1008
A	TYR1056
A	HOH1316
A	HOH1352
A	HOH1418
A	HOH1420
A	HOH1430
A	HOH1444

---

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 A 1205

Chain	Residue
A	SER1001
A	GLU1032
A	ARG1092

---

site_id	AC6
Number of Residues	22
Details	binding site for residue O31 A 1206

Chain	Residue
A	HIS982
A	GLN1041
A	THR1042
A	PHE1043
A	HIS1057
A	ASP1081
A	LEU1132
A	LEU1135
A	LYS1136
A	GLY1137
A	SER1138
A	SER1139
A	PHE1154
A	ARG1155
A	ALA1156
A	ALA1157
A	HOH1356
A	HOH1409
A	HOH1411
A	HOH1415
A	HOH1432
A	HOH1446

---

site_id	AC7
Number of Residues	3
Details	binding site for residue CL A 1207

Chain	Residue
A	ARG1155
A	SER1174
A	HOH1421

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166

Chain	Residue	Details
A	HIS1057
A	ASP1081
A	SER1139

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01166

Chain	Residue	Details
A	CYS1097
A	CYS1099
A	CYS1145
A	HIS1149

---