Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6P59

Crystal structure of SIVrcm Vif-CBFbeta-ELOB-ELOC complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000209	biological_process	protein polyubiquitination
A	0003677	molecular_function	DNA binding
A	0003713	molecular_function	transcription coactivator activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006366	biological_process	transcription by RNA polymerase II
A	0016020	cellular_component	membrane
A	0016513	cellular_component	core-binding factor complex
A	0043371	biological_process	negative regulation of CD4-positive, alpha-beta T cell differentiation
A	0043378	biological_process	positive regulation of CD8-positive, alpha-beta T cell differentiation
A	0043565	molecular_function	sequence-specific DNA binding
A	0045893	biological_process	positive regulation of DNA-templated transcription
B	0019058	biological_process	viral life cycle
B	0020002	cellular_component	host cell plasma membrane
B	0030430	cellular_component	host cell cytoplasm
B	0044423	cellular_component	virion component
B	0046872	molecular_function	metal ion binding
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000209	biological_process	protein polyubiquitination
C	0003677	molecular_function	DNA binding
C	0003713	molecular_function	transcription coactivator activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006366	biological_process	transcription by RNA polymerase II
C	0016020	cellular_component	membrane
C	0016513	cellular_component	core-binding factor complex
C	0043371	biological_process	negative regulation of CD4-positive, alpha-beta T cell differentiation
C	0043378	biological_process	positive regulation of CD8-positive, alpha-beta T cell differentiation
C	0043565	molecular_function	sequence-specific DNA binding
C	0045893	biological_process	positive regulation of DNA-templated transcription
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000151	cellular_component	ubiquitin ligase complex
D	0001222	molecular_function	transcription corepressor binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006351	biological_process	DNA-templated transcription
D	0006367	biological_process	transcription initiation at RNA polymerase II promoter
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0016567	biological_process	protein ubiquitination
D	0030891	cellular_component	VCB complex
D	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
D	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0065003	biological_process	protein-containing complex assembly
D	0070449	cellular_component	elongin complex
D	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
D	0140958	biological_process	target-directed miRNA degradation
D	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
D	2000104	biological_process	negative regulation of DNA-templated DNA replication
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0000151	cellular_component	ubiquitin ligase complex
E	0001222	molecular_function	transcription corepressor binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006351	biological_process	DNA-templated transcription
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0006367	biological_process	transcription initiation at RNA polymerase II promoter
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0016567	biological_process	protein ubiquitination
E	0030674	molecular_function	protein-macromolecule adaptor activity
E	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
E	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0070449	cellular_component	elongin complex
E	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
E	0140958	biological_process	target-directed miRNA degradation
E	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
E	2000104	biological_process	negative regulation of DNA-templated DNA replication
F	0019058	biological_process	viral life cycle
F	0020002	cellular_component	host cell plasma membrane
F	0030430	cellular_component	host cell cytoplasm
F	0044423	cellular_component	virion component
F	0046872	molecular_function	metal ion binding
W	0000122	biological_process	negative regulation of transcription by RNA polymerase II
W	0000151	cellular_component	ubiquitin ligase complex
W	0001222	molecular_function	transcription corepressor binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0006351	biological_process	DNA-templated transcription
W	0006367	biological_process	transcription initiation at RNA polymerase II promoter
W	0006368	biological_process	transcription elongation by RNA polymerase II
W	0016567	biological_process	protein ubiquitination
W	0030891	cellular_component	VCB complex
W	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
W	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
W	0031625	molecular_function	ubiquitin protein ligase binding
W	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0065003	biological_process	protein-containing complex assembly
W	0070449	cellular_component	elongin complex
W	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
W	0140958	biological_process	target-directed miRNA degradation
W	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
W	2000104	biological_process	negative regulation of DNA-templated DNA replication
Z	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Z	0000151	cellular_component	ubiquitin ligase complex
Z	0001222	molecular_function	transcription corepressor binding
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005737	cellular_component	cytoplasm
Z	0005829	cellular_component	cytosol
Z	0006351	biological_process	DNA-templated transcription
Z	0006357	biological_process	regulation of transcription by RNA polymerase II
Z	0006367	biological_process	transcription initiation at RNA polymerase II promoter
Z	0006511	biological_process	ubiquitin-dependent protein catabolic process
Z	0016567	biological_process	protein ubiquitination
Z	0030674	molecular_function	protein-macromolecule adaptor activity
Z	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
Z	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
Z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Z	0070449	cellular_component	elongin complex
Z	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
Z	0140958	biological_process	target-directed miRNA degradation
Z	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
Z	2000104	biological_process	negative regulation of DNA-templated DNA replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN F 301

Chain	Residue
F	HIS115
F	CYS121
F	CYS139
F	HIS145

site_id	AC2
Number of Residues	4
Details	binding site for residue GOL F 302

Chain	Residue
F	ARG143
F	HIS208
F	PHE209
F	SER211

site_id	AC3
Number of Residues	1
Details	binding site for residue MES A 201

Chain	Residue
A	ARG52

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN B 301

Chain	Residue
B	HIS115
B	CYS121
B	CYS139
B	HIS145

site_id	AC5
Number of Residues	5
Details	binding site for residue GOL B 302

Chain	Residue
B	ARG143
B	HIS208
B	PHE209
B	SER211
B	TYR214

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	130
Details	Domain: {"description":"Ubiquitin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62869","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)