6P4U

The structure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo1 serine module in complex with Mg and AMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue AMP A 3101

Chain	Residue
A	GLY2869
A	ASP2985
A	TYR2997
A	MG3102
A	HOH3201
A	HOH3221
A	HOH3224
A	HOH3241
A	HOH3251
A	GLU2870
A	ALA2871
A	ASN2891
A	LEU2892
A	TYR2893
A	GLY2894
A	PRO2895
A	THR2896

---

site_id	AC2
Number of Residues	7
Details	binding site for residue MG A 3102

Chain	Residue
A	GLY2894
A	VAL2900
A	ASP2901
A	AMP3101
A	HOH3201
A	HOH3224
A	HOH3251

---

site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 A 3103

Chain	Residue
A	ASP2649
A	ARG2651
A	LEU2747
A	ARG2954
A	SO43104
A	HOH3292

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 A 3104

Chain	Residue
A	TYR2956
A	GLY2958
A	SO43103
A	HOH3256

---

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 A 3105

Chain	Residue
A	ARG2632
A	GLN2633
A	ARG2636

---

site_id	AC6
Number of Residues	5
Details	binding site for residue SO4 A 3106

Chain	Residue
A	ALA2139
A	ARG2632
A	ARG2636
A	ALA2732
A	GLN2733

---

site_id	AC7
Number of Residues	5
Details	binding site for residue SO4 A 3107

Chain	Residue
A	ARG2550
A	GLU2580
A	ARG2583
A	HOH3217
A	HOH3291

---

site_id	AC8
Number of Residues	3
Details	binding site for residue SO4 A 3108

Chain	Residue
A	HIS2745
A	HIS2746
A	HOH3211

---

site_id	AC9
Number of Residues	4
Details	binding site for residue SO4 A 3109

Chain	Residue
A	SER2704
A	GLY2721
A	GLU2722
A	HOH3280

---

site_id	AD1
Number of Residues	2
Details	binding site for residue SO4 A 3110

Chain	Residue
A	GLN2778
A	SO43118

---

site_id	AD2
Number of Residues	4
Details	binding site for residue SO4 A 3111

Chain	Residue
A	GLU2854
A	GLY2855
A	VAL2856
A	GLN2857

---

site_id	AD3
Number of Residues	2
Details	binding site for residue SO4 A 3112

Chain	Residue
A	GLU2766
A	ARG2979

---

site_id	AD4
Number of Residues	3
Details	binding site for residue SO4 A 3113

Chain	Residue
A	SER2756
A	ARG3000
A	ASP3002

---

site_id	AD5
Number of Residues	3
Details	binding site for residue SO4 A 3114

Chain	Residue
A	GLY2322
A	GLU2323
A	ARG2324

---

site_id	AD6
Number of Residues	1
Details	binding site for residue SO4 A 3115

Chain	Residue
A	ARG2593

---

site_id	AD7
Number of Residues	2
Details	binding site for residue SO4 A 3116

Chain	Residue
A	PRO2684
A	ALA2685

---

site_id	AD8
Number of Residues	3
Details	binding site for residue SO4 A 3117

Chain	Residue
A	GLY2755
A	ARG2966
A	HOH3264

---

site_id	AD9
Number of Residues	3
Details	binding site for residue SO4 A 3118

Chain	Residue
A	ALA2809
A	VAL2810
A	SO43110

---

site_id	AE1
Number of Residues	2
Details	binding site for residue SO4 A 3119

Chain	Residue
A	TRP2315
A	ARG2324

---

site_id	AE2
Number of Residues	2
Details	binding site for residue CL A 3120

Chain	Residue
A	PRO2960
A	GLU2961

---

site_id	AE3
Number of Residues	3
Details	binding site for residue ACT A 3121

Chain	Residue
A	THR2598
A	GLU2603
A	VAL2742

---

site_id	AE4
Number of Residues	4
Details	binding site for residue GOL A 3122

Chain	Residue
A	GLY2934
A	HIS2946
A	PRO2976
A	LYS2982

---

site_id	AE5
Number of Residues	4
Details	binding site for residue GOL A 3123

Chain	Residue
A	ARG2658
A	LYS2792
A	PRO2794
A	GLN2820

---

site_id	AE6
Number of Residues	1
Details	binding site for residue FMT A 3124

Chain	Residue
A	VAL2843

---

Functional Information from PROSITE/UniProt

site_id	PS00455
Number of Residues	12
Details	AMP_BINDING Putative AMP-binding domain signature. VIYTSGSTGrPK

Chain	Residue	Details
A	VAL2750-LYS2761

---