6P4O
Complex of XPB helicase with Bax1 endonuclease from Sulfurisphaera tokodaii at 3.15 Angstroms resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004386 | molecular_function | helicase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006281 | biological_process | DNA repair |
| A | 0006974 | biological_process | DNA damage response |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0043138 | molecular_function | 3'-5' DNA helicase activity |
| A | 0120545 | molecular_function | nucleic acid conformation isomerase activity |
| A | 0140097 | molecular_function | catalytic activity, acting on DNA |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004518 | molecular_function | nuclease activity |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0006281 | biological_process | DNA repair |
| B | 0006974 | biological_process | DNA damage response |
| B | 0016787 | molecular_function | hydrolase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0004386 | molecular_function | helicase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006281 | biological_process | DNA repair |
| C | 0006974 | biological_process | DNA damage response |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0043138 | molecular_function | 3'-5' DNA helicase activity |
| C | 0120545 | molecular_function | nucleic acid conformation isomerase activity |
| C | 0140097 | molecular_function | catalytic activity, acting on DNA |
| D | 0003677 | molecular_function | DNA binding |
| D | 0004518 | molecular_function | nuclease activity |
| D | 0004519 | molecular_function | endonuclease activity |
| D | 0006281 | biological_process | DNA repair |
| D | 0006974 | biological_process | DNA damage response |
| D | 0016787 | molecular_function | hydrolase activity |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0003677 | molecular_function | DNA binding |
| E | 0004386 | molecular_function | helicase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0006281 | biological_process | DNA repair |
| E | 0006974 | biological_process | DNA damage response |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0016853 | molecular_function | isomerase activity |
| E | 0043138 | molecular_function | 3'-5' DNA helicase activity |
| E | 0120545 | molecular_function | nucleic acid conformation isomerase activity |
| E | 0140097 | molecular_function | catalytic activity, acting on DNA |
| F | 0003677 | molecular_function | DNA binding |
| F | 0004518 | molecular_function | nuclease activity |
| F | 0004519 | molecular_function | endonuclease activity |
| F | 0006281 | biological_process | DNA repair |
| F | 0006974 | biological_process | DNA damage response |
| F | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue GOL A 501 |
| Chain | Residue |
| A | GLU162 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 502 |
| Chain | Residue |
| A | GLU228 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 503 |
| Chain | Residue |
| A | GLN273 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 504 |
| Chain | Residue |
| A | GLU211 |
| A | HOH605 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 501 |
| Chain | Residue |
| B | ALA7 |
| B | PHE9 |
| B | LYS59 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue GOL E 501 |
| Chain | Residue |
| E | GLN189 |
| E | HOH602 |
| C | TRP22 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue CL F 501 |
| Chain | Residue |
| F | LYS59 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 432 |
| Details | Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 128 |
| Details | Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 159 |
| Details | Region: {"description":"DRD domain","evidences":[{"source":"PubMed","id":"32374860","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 21 |
| Details | Region: {"description":"Flexible hinge region","evidences":[{"source":"PubMed","id":"32374860","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 177 |
| Details | Region: {"description":"ThM region","evidences":[{"source":"PubMed","id":"32374860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32986831","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 9 |
| Details | Motif: {"description":"DEAH box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | Motif: {"description":"RED motif","evidences":[{"source":"PubMed","id":"32374860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32986831","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32986831","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32986831","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | Site: {"description":"Wedge residue","evidences":[{"source":"PubMed","id":"32986831","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 405 |
| Details | Region: {"description":"N-terminal domain (NTD)","evidences":[{"source":"PubMed","id":"32374860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32986831","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 276 |
| Details | Region: {"description":"Central domain (CRD)","evidences":[{"source":"PubMed","id":"32374860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32986831","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 312 |
| Details | Region: {"description":"Nuclease domain (NUS)","evidences":[{"source":"PubMed","id":"32374860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32986831","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"O29890","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 67 |
| Details | Region: {"description":"C-terminal domain (CTD)","evidences":[{"source":"PubMed","id":"32374860","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
