6P3C
E. coli fumarase mutant - T187A
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004333 | molecular_function | fumarate hydratase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006099 | biological_process | tricarboxylic acid cycle |
A | 0006106 | biological_process | fumarate metabolic process |
A | 0006108 | biological_process | malate metabolic process |
A | 0006979 | biological_process | response to oxidative stress |
A | 0016829 | molecular_function | lyase activity |
A | 0042802 | molecular_function | identical protein binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0004333 | molecular_function | fumarate hydratase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006099 | biological_process | tricarboxylic acid cycle |
B | 0006106 | biological_process | fumarate metabolic process |
B | 0006108 | biological_process | malate metabolic process |
B | 0006979 | biological_process | response to oxidative stress |
B | 0016829 | molecular_function | lyase activity |
B | 0042802 | molecular_function | identical protein binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | binding site for residue FLC A 501 |
Chain | Residue |
A | MET124 |
A | ARG126 |
A | HIS129 |
A | PRO130 |
A | ASN131 |
A | ASP132 |
A | HOH605 |
A | HOH610 |
site_id | AC2 |
Number of Residues | 8 |
Details | binding site for residue FLC B 501 |
Chain | Residue |
B | ARG126 |
B | HIS129 |
B | PRO130 |
B | ASN131 |
B | ASP132 |
B | HOH604 |
B | HOH610 |
B | MET124 |
Functional Information from PROSITE/UniProt
site_id | PS00163 |
Number of Residues | 10 |
Details | FUMARATE_LYASES Fumarate lyases signature. GSsiMpGKvN |
Chain | Residue | Details |
A | GLY317-ASN326 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00743","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"9098893","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00743","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00743","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12021453","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"8909293","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9098893","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1FUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FUP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FUQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KQ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FUS","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"8909293","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9098893","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FUP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FUQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FUR","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | Binding site: {"description":"in site B","evidences":[{"source":"PubMed","id":"12021453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8909293","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9098893","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FUP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FUQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KQ7","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00743","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12021453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8909293","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9098893","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FUP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FUQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KQ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FUS","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI7 |
Number of Residues | 8 |
Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00743","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | Site: {"description":"Important for catalytic activity","evidences":[{"source":"HAMAP-Rule","id":"MF_00743","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8909293","evidenceCode":"ECO:0000305"}]} |
Chain | Residue | Details |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 569 |
Chain | Residue | Details |
A | HIS188 | electrostatic stabiliser, proton acceptor |
A | SER318 | proton donor |
A | LYS324 | electrostatic stabiliser |
A | GLU331 | increase basicity |
site_id | MCSA2 |
Number of Residues | 4 |
Details | M-CSA 569 |
Chain | Residue | Details |
B | HIS188 | electrostatic stabiliser, proton acceptor |
B | SER318 | proton donor |
B | LYS324 | electrostatic stabiliser |
B | GLU331 | increase basicity |