6P1Y

Crystal structure of Mtb aspartate decarboxylase mutant M117I

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004068	molecular_function	aspartate 1-decarboxylase activity
A	0006523	biological_process	alanine biosynthetic process
B	0004068	molecular_function	aspartate 1-decarboxylase activity
B	0006523	biological_process	alanine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue NH4 A 101

Chain	Residue
A	LYS9
A	VAL23
A	HOH204
B	TLA201

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site_id	AC2
Number of Residues	11
Details	binding site for residue TLA B 201

Chain	Residue
B	TYR58
B	ASN72
B	GLY73
B	ALA74
B	ALA75
B	ILE86
A	LYS9
A	NH4101
B	PYR25
B	VAL47
B	ARG54

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Schiff-base intermediate with substrate; via pyruvic acid => ECO:0000255|HAMAP-Rule:MF_00446

Chain	Residue	Details
B	PYR25

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_00446

Chain	Residue	Details
B	TYR58

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00446

Chain	Residue	Details
B	THR57
B	GLY73

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Pyruvic acid (Ser) => ECO:0000255|HAMAP-Rule:MF_00446

Chain	Residue	Details
B	PYR25

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