6P1J

The structure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo2 serine module

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
B	0003824	molecular_function	catalytic activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue FMT A 1101

Chain	Residue
A	THR665
A	LYS669
A	LEU870
A	ARG874

---

site_id	AC2
Number of Residues	10
Details	binding site for residue FLC A 1102

Chain	Residue
A	ARG951
A	TYR955
A	ALA985
A	VAL987
A	CL1106
A	ARG667
A	ARG867
A	PRO868
A	GLU869
A	LEU870

---

site_id	AC3
Number of Residues	5
Details	binding site for residue ACT A 1103

Chain	Residue
A	ALA65
A	HIS71
A	PRO147
A	PHE148
A	HIS175

---

site_id	AC4
Number of Residues	1
Details	binding site for residue CL A 1105

Chain	Residue
A	ARG491

---

site_id	AC5
Number of Residues	1
Details	binding site for residue CL A 1106

Chain	Residue
A	FLC1102

---

site_id	AC6
Number of Residues	2
Details	binding site for residue CL A 1107

Chain	Residue
A	PHE705
A	LYS999

---

site_id	AC7
Number of Residues	3
Details	binding site for residue CL A 1108

Chain	Residue
A	THR338
A	LEU339
A	VAL376

---

site_id	AC8
Number of Residues	1
Details	binding site for residue CL A 1109

Chain	Residue
A	GLN242

---

site_id	AC9
Number of Residues	1
Details	binding site for residue GOL A 1110

Chain	Residue
A	HOH1210

---

site_id	AD1
Number of Residues	4
Details	binding site for residue GOL A 1111

Chain	Residue
A	THR292
A	LEU293
A	TYR294
A	TRP398

---

site_id	AD2
Number of Residues	1
Details	binding site for residue GOL A 1112

Chain	Residue
A	ALA840

---

site_id	AD3
Number of Residues	4
Details	binding site for residue GOL A 1113

Chain	Residue
A	TYR294
A	PRO319
A	VAL320
A	TRP398

---

site_id	AD4
Number of Residues	3
Details	binding site for residue GOL A 1114

Chain	Residue
A	GLY777
A	TYR801
A	ASP893

---

site_id	AD5
Number of Residues	3
Details	binding site for residue SO4 A 1115

Chain	Residue
A	ARG559
A	MET672
A	LEU865

---

site_id	AD6
Number of Residues	4
Details	binding site for residue SO4 A 1116

Chain	Residue
A	SER662
A	GLY663
A	SER664
A	HOH1201

---

site_id	AD7
Number of Residues	1
Details	binding site for residue FMT B 1101

Chain	Residue
B	ALA840

---

site_id	AD8
Number of Residues	3
Details	binding site for residue FMT B 1102

Chain	Residue
B	ALA487
B	GLU488
B	HOH1223

---

site_id	AD9
Number of Residues	1
Details	binding site for residue FMT B 1103

Chain	Residue
B	THR338

---

site_id	AE1
Number of Residues	5
Details	binding site for residue FMT B 1104

Chain	Residue
B	GLY663
B	SER664
B	THR665
B	LYS669
B	HOH1208

---

site_id	AE2
Number of Residues	9
Details	binding site for residue FLC B 1105

Chain	Residue
B	ARG667
B	ARG867
B	PRO868
B	GLU869
B	LEU870
B	ARG951
B	TYR955
B	ALA985
B	VAL987

---

site_id	AE3
Number of Residues	1
Details	binding site for residue CL B 1106

Chain	Residue
B	HIS175

---

site_id	AE4
Number of Residues	2
Details	binding site for residue CL B 1107

Chain	Residue
B	TRP240
B	PHE373

---

site_id	AE5
Number of Residues	2
Details	binding site for residue CL B 1109

Chain	Residue
B	ARG559
B	LEU865

---

site_id	AE6
Number of Residues	2
Details	binding site for residue CL B 1111

Chain	Residue
B	HOH1201
B	HOH1201

---

site_id	AE7
Number of Residues	3
Details	binding site for residue CL B 1113

Chain	Residue
B	ALA100
B	GLN216
B	ILE332

---

site_id	AE8
Number of Residues	2
Details	binding site for residue CL B 1114

Chain	Residue
B	ILE920
B	LEU922

---

site_id	AE9
Number of Residues	1
Details	binding site for residue CL B 1116

Chain	Residue
B	LEU484

---

site_id	AF1
Number of Residues	1
Details	binding site for residue CL B 1117

Chain	Residue
B	GLN242

---

Functional Information from PROSITE/UniProt

site_id	PS00455
Number of Residues	12
Details	AMP_BINDING Putative AMP-binding domain signature. VIYTSGSTGrPK

Chain	Residue	Details
A	VAL658-LYS669

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