6OZ5
Escherichia coli tRNA synthetase in complex with compound 3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004826 | molecular_function | phenylalanine-tRNA ligase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006432 | biological_process | phenylalanyl-tRNA aminoacylation |
| A | 0009328 | cellular_component | phenylalanine-tRNA ligase complex |
| A | 0043039 | biological_process | tRNA aminoacylation |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004826 | molecular_function | phenylalanine-tRNA ligase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006432 | biological_process | phenylalanyl-tRNA aminoacylation |
| B | 0009328 | cellular_component | phenylalanine-tRNA ligase complex |
| B | 0016020 | cellular_component | membrane |
| B | 0042802 | molecular_function | identical protein binding |
| C | 0000049 | molecular_function | tRNA binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| C | 0004826 | molecular_function | phenylalanine-tRNA ligase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006432 | biological_process | phenylalanyl-tRNA aminoacylation |
| C | 0009328 | cellular_component | phenylalanine-tRNA ligase complex |
| C | 0043039 | biological_process | tRNA aminoacylation |
| D | 0000049 | molecular_function | tRNA binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003723 | molecular_function | RNA binding |
| D | 0004826 | molecular_function | phenylalanine-tRNA ligase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006432 | biological_process | phenylalanyl-tRNA aminoacylation |
| D | 0009328 | cellular_component | phenylalanine-tRNA ligase complex |
| D | 0016020 | cellular_component | membrane |
| D | 0042802 | molecular_function | identical protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue VB3 A 401 |
| Chain | Residue |
| A | GLN169 |
| A | GLY296 |
| A | SER171 |
| A | GLN174 |
| A | GLU210 |
| A | PHE248 |
| A | PHE250 |
| A | GLY271 |
| A | CYS272 |
| A | PHE295 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | GLU252 |
| A | HOH508 |
| B | GLU463 |
| B | HOH912 |
| B | HOH917 |
| B | HOH919 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 801 |
| Chain | Residue |
| B | ARG568 |
| B | ASP616 |
| B | HOH905 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 802 |
| Chain | Residue |
| B | PRO401 |
| B | SER450 |
| B | ARG452 |
| B | PHE453 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue PEG B 803 |
| Chain | Residue |
| B | MET1 |
| B | ILE160 |
| B | VAL162 |
| B | ASP355 |
| B | HIS358 |
| B | ARG359 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 804 |
| Chain | Residue |
| B | HIS265 |
| B | MET313 |
| B | GLY315 |
| B | GLU334 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | binding site for residue VB3 C 401 |
| Chain | Residue |
| C | GLN169 |
| C | GLN174 |
| C | GLU210 |
| C | PHE248 |
| C | PHE250 |
| C | GLY271 |
| C | CYS272 |
| C | ALA294 |
| C | PHE295 |
| C | GLY296 |
| C | HOH505 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 402 |
| Chain | Residue |
| C | GLU252 |
| C | HOH519 |
| D | GLU463 |
| D | HOH924 |
| D | HOH943 |
| D | HOH953 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 801 |
| Chain | Residue |
| D | PHE122 |
| D | SER128 |
| D | GLU236 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 802 |
| Chain | Residue |
| D | PRO366 |
| D | PRO401 |
| D | SER450 |
| D | ARG452 |
| D | PHE453 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 803 |
| Chain | Residue |
| D | ILE304 |
| D | GLY314 |
| D | GLY315 |
| D | GLU334 |
| D | HOH901 |
| D | HOH908 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 804 |
| Chain | Residue |
| D | TRP7 |
| D | GLU10 |
| D | TRP11 |
| D | PRO190 |
| D | LYS237 |
| D | GLU259 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 805 |
| Chain | Residue |
| A | LYS327 |
| B | ASN503 |
| D | ARG497 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue PGE D 806 |
| Chain | Residue |
| D | MET1 |
| D | SER161 |
| D | VAL162 |
| D | HIS353 |
| D | ASP355 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 218 |
| Details | Domain: {"description":"tRNA-binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 150 |
| Details | Domain: {"description":"B5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 93 |
| Details | Domain: {"description":"FDX-ACB"} |
| Chain | Residue | Details |
