Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6OZ5

Escherichia coli tRNA synthetase in complex with compound 3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004826	molecular_function	phenylalanine-tRNA ligase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006412	biological_process	translation
A	0006432	biological_process	phenylalanyl-tRNA aminoacylation
A	0009328	cellular_component	phenylalanine-tRNA ligase complex
A	0043039	biological_process	tRNA aminoacylation
A	0046872	molecular_function	metal ion binding
B	0000049	molecular_function	tRNA binding
B	0000287	molecular_function	magnesium ion binding
B	0003723	molecular_function	RNA binding
B	0004812	molecular_function	aminoacyl-tRNA ligase activity
B	0004826	molecular_function	phenylalanine-tRNA ligase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006412	biological_process	translation
B	0006432	biological_process	phenylalanyl-tRNA aminoacylation
B	0009328	cellular_component	phenylalanine-tRNA ligase complex
B	0016020	cellular_component	membrane
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
C	0000049	molecular_function	tRNA binding
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0004812	molecular_function	aminoacyl-tRNA ligase activity
C	0004826	molecular_function	phenylalanine-tRNA ligase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006412	biological_process	translation
C	0006432	biological_process	phenylalanyl-tRNA aminoacylation
C	0009328	cellular_component	phenylalanine-tRNA ligase complex
C	0043039	biological_process	tRNA aminoacylation
C	0046872	molecular_function	metal ion binding
D	0000049	molecular_function	tRNA binding
D	0000287	molecular_function	magnesium ion binding
D	0003723	molecular_function	RNA binding
D	0004812	molecular_function	aminoacyl-tRNA ligase activity
D	0004826	molecular_function	phenylalanine-tRNA ligase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006412	biological_process	translation
D	0006432	biological_process	phenylalanyl-tRNA aminoacylation
D	0009328	cellular_component	phenylalanine-tRNA ligase complex
D	0016020	cellular_component	membrane
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue VB3 A 401

Chain	Residue
A	GLN169
A	GLY296
A	SER171
A	GLN174
A	GLU210
A	PHE248
A	PHE250
A	GLY271
A	CYS272
A	PHE295

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 402

Chain	Residue
A	GLU252
A	HOH508
B	GLU463
B	HOH912
B	HOH917
B	HOH919

site_id	AC3
Number of Residues	3
Details	binding site for residue EDO B 801

Chain	Residue
B	ARG568
B	ASP616
B	HOH905

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO B 802

Chain	Residue
B	PRO401
B	SER450
B	ARG452
B	PHE453

site_id	AC5
Number of Residues	6
Details	binding site for residue PEG B 803

Chain	Residue
B	MET1
B	ILE160
B	VAL162
B	ASP355
B	HIS358
B	ARG359

site_id	AC6
Number of Residues	4
Details	binding site for residue EDO B 804

Chain	Residue
B	HIS265
B	MET313
B	GLY315
B	GLU334

site_id	AC7
Number of Residues	11
Details	binding site for residue VB3 C 401

Chain	Residue
C	GLN169
C	GLN174
C	GLU210
C	PHE248
C	PHE250
C	GLY271
C	CYS272
C	ALA294
C	PHE295
C	GLY296
C	HOH505

site_id	AC8
Number of Residues	6
Details	binding site for residue MG C 402

Chain	Residue
C	GLU252
C	HOH519
D	GLU463
D	HOH924
D	HOH943
D	HOH953

site_id	AC9
Number of Residues	3
Details	binding site for residue EDO D 801

Chain	Residue
D	PHE122
D	SER128
D	GLU236

site_id	AD1
Number of Residues	5
Details	binding site for residue EDO D 802

Chain	Residue
D	PRO366
D	PRO401
D	SER450
D	ARG452
D	PHE453

site_id	AD2
Number of Residues	6
Details	binding site for residue EDO D 803

Chain	Residue
D	ILE304
D	GLY314
D	GLY315
D	GLU334
D	HOH901
D	HOH908

site_id	AD3
Number of Residues	6
Details	binding site for residue EDO D 804

Chain	Residue
D	TRP7
D	GLU10
D	TRP11
D	PRO190
D	LYS237
D	GLU259

site_id	AD4
Number of Residues	3
Details	binding site for residue EDO D 805

Chain	Residue
A	LYS327
B	ASN503
D	ARG497

site_id	AD5
Number of Residues	5
Details	binding site for residue PGE D 806

Chain	Residue
D	MET1
D	SER161
D	VAL162
D	HIS353
D	ASP355

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
B	ASP454
B	ASP460
B	GLU463
B	GLU464
D	GLU463
D	GLU464
D	ASP454
D	ASP460

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)