6OYA

Structure of the Rhodopsin-Transducin-Nanobody Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000035	molecular_function	acyl binding
A	0000166	molecular_function	nucleotide binding
A	0001664	molecular_function	G protein-coupled receptor binding
A	0001750	cellular_component	photoreceptor outer segment
A	0001917	cellular_component	photoreceptor inner segment
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005834	cellular_component	heterotrimeric G-protein complex
A	0007165	biological_process	signal transduction
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
A	0007601	biological_process	visual perception
A	0007602	biological_process	phototransduction
A	0007603	biological_process	phototransduction, visible light
A	0009416	biological_process	response to light stimulus
A	0016020	cellular_component	membrane
A	0019001	molecular_function	guanyl nucleotide binding
A	0019003	molecular_function	GDP binding
A	0019901	molecular_function	protein kinase binding
A	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
A	0042622	cellular_component	photoreceptor outer segment membrane
A	0042995	cellular_component	cell projection
A	0046872	molecular_function	metal ion binding
A	0050908	biological_process	detection of light stimulus involved in visual perception
A	0051344	biological_process	negative regulation of cyclic-nucleotide phosphodiesterase activity
A	0097381	cellular_component	photoreceptor disc membrane
A	0097648	cellular_component	G protein-coupled receptor complex
B	0001750	cellular_component	photoreceptor outer segment
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005834	cellular_component	heterotrimeric G-protein complex
B	0007165	biological_process	signal transduction
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
B	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
B	0008283	biological_process	cell population proliferation
B	0016020	cellular_component	membrane
B	0030159	molecular_function	signaling receptor complex adaptor activity
B	0044877	molecular_function	protein-containing complex binding
B	0045202	cellular_component	synapse
B	0050909	biological_process	sensory perception of taste
B	0051020	molecular_function	GTPase binding
B	0060041	biological_process	retina development in camera-type eye
B	0071380	biological_process	cellular response to prostaglandin E stimulus
B	0071870	biological_process	cellular response to catecholamine stimulus
B	0097381	cellular_component	photoreceptor disc membrane
G	0005834	cellular_component	heterotrimeric G-protein complex
G	0005886	cellular_component	plasma membrane
G	0007165	biological_process	signal transduction
G	0007186	biological_process	G protein-coupled receptor signaling pathway
G	0007602	biological_process	phototransduction
G	0008104	biological_process	intracellular protein localization
G	0016020	cellular_component	membrane
G	0031681	molecular_function	G-protein beta-subunit binding
G	0042462	biological_process	eye photoreceptor cell development
G	0097381	cellular_component	photoreceptor disc membrane
R	0000139	cellular_component	Golgi membrane
R	0000226	biological_process	microtubule cytoskeleton organization
R	0001750	cellular_component	photoreceptor outer segment
R	0001917	cellular_component	photoreceptor inner segment
R	0001965	molecular_function	G-protein alpha-subunit binding
R	0002046	molecular_function	opsin binding
R	0004930	molecular_function	G protein-coupled receptor activity
R	0005085	molecular_function	guanyl-nucleotide exchange factor activity
R	0005502	molecular_function	11-cis retinal binding
R	0005515	molecular_function	protein binding
R	0005794	cellular_component	Golgi apparatus
R	0005886	cellular_component	plasma membrane
R	0005911	cellular_component	cell-cell junction
R	0007165	biological_process	signal transduction
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0007601	biological_process	visual perception
R	0007602	biological_process	phototransduction
R	0007603	biological_process	phototransduction, visible light
R	0008020	molecular_function	G protein-coupled photoreceptor activity
R	0008270	molecular_function	zinc ion binding
R	0009416	biological_process	response to light stimulus
R	0009583	biological_process	detection of light stimulus
R	0009642	biological_process	response to light intensity
R	0009881	molecular_function	photoreceptor activity
R	0010467	biological_process	gene expression
R	0016020	cellular_component	membrane
R	0016038	biological_process	absorption of visible light
R	0016056	biological_process	G protein-coupled opsin signaling pathway
R	0019867	cellular_component	outer membrane
R	0042622	cellular_component	photoreceptor outer segment membrane
R	0042802	molecular_function	identical protein binding
R	0042995	cellular_component	cell projection
R	0043052	biological_process	thermotaxis
R	0045494	biological_process	photoreceptor cell maintenance
R	0046872	molecular_function	metal ion binding
R	0050953	biological_process	sensory perception of light stimulus
R	0050960	biological_process	detection of temperature stimulus involved in thermoception
R	0060041	biological_process	retina development in camera-type eye
R	0060342	cellular_component	photoreceptor inner segment membrane
R	0071482	biological_process	cellular response to light stimulus
R	0071800	biological_process	podosome assembly
R	0097225	cellular_component	sperm midpiece
R	0097381	cellular_component	photoreceptor disc membrane
R	0097648	cellular_component	G protein-coupled receptor complex
R	0120200	cellular_component	rod photoreceptor outer segment
R	1904389	biological_process	rod bipolar cell differentiation
R	1990763	molecular_function	arrestin family protein binding
R	1990913	cellular_component	sperm head plasma membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue RET R 401

Chain	Residue
R	ALA117
R	GLU122
R	TYR268
R	LYS296

---

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. IALwSLVVLAIERYVvV

Chain	Residue	Details
R	ILE123-VAL139

---

site_id	PS00238
Number of Residues	17
Details	OPSIN Visual pigments (opsins) retinal binding site. IPaFfAKTSAvyNPviY

Chain	Residue	Details
R	ILE290-TYR306

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSAsqDgKLIIWDS

Chain	Residue	Details
B	LEU70-SER84
B	ILE157-ILE171
B	LEU285-ALA299

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	13
Details	Region: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Region: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Region: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	Region: {"description":"Interaction with RHO","evidences":[{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389988","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9539726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	14
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7969474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8208289","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8259210","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FQJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GOT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TAD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TND","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V00","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8259210","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TND","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7969474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8208289","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8259210","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GOT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TAD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TND","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	48
Details	Repeat: {"description":"WD 1","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	45
Details	Repeat: {"description":"WD 2","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	40
Details	Repeat: {"description":"WD 3","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	41
Details	Repeat: {"description":"WD 4","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	43
Details	Repeat: {"description":"WD 5","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	41
Details	Repeat: {"description":"WD 6","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	30
Details	Repeat: {"description":"WD 7","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	Modified residue: {"description":"Phosphohistidine","evidences":[{"source":"PubMed","id":"12486123","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	87
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	56
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	2
Details	Motif: {"description":"'Ionic lock' involved in activated form stabilization","evidences":[{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HZX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	1
Details	Site: {"description":"Plays an important role in the conformation switch to the active conformation","evidences":[{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"6759163","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	1
Details	Modified residue: {"description":"N6-(retinylidene)lysine","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23303210","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6870827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6759163","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1F88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GZM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HPY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3C9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3OAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DYS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	1
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1512231","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3350146","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1L9H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HPY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DYS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	1
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1512231","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3350146","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1L9H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HPY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BEY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PXF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DYS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"468821","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6759163","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GZM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U19","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2G87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HPY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I35","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I37","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PED","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3C9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CAP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3OAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X1H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"468821","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6759163","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GZM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1L9H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U19","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2G87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HPY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I35","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I37","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J4Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PED","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X72","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3C9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CAP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3OAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4A4M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BEY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J4Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PXF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DYS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TE3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---