6OXD

Structure of Mycobacterium tuberculosis methylmalonyl-CoA mutase with adenosyl cobalamin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004494	molecular_function	methylmalonyl-CoA mutase activity
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0016853	molecular_function	isomerase activity
A	0016866	molecular_function	intramolecular transferase activity
A	0019678	biological_process	propionate metabolic process, methylmalonyl pathway
A	0031419	molecular_function	cobalamin binding
A	0046872	molecular_function	metal ion binding
B	0003824	molecular_function	catalytic activity
B	0004494	molecular_function	methylmalonyl-CoA mutase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0016853	molecular_function	isomerase activity
B	0016866	molecular_function	intramolecular transferase activity
B	0019652	biological_process	lactate fermentation to propionate and acetate
B	0019678	biological_process	propionate metabolic process, methylmalonyl pathway
B	0031419	molecular_function	cobalamin binding
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	43
Details	binding site for residue B12 A 1000

Chain	Residue
A	TYR105
A	GLY349
A	TRP350
A	LEU352
A	GLU386
A	ALA387
A	ALA389
A	LEU390
A	GLN470
A	GLY628
A	HIS629
A	PHE133
A	ASP630
A	ARG631
A	GLY632
A	GLY672
A	SER674
A	LEU676
A	ALA678
A	GLY704
A	GLY705
A	PHE724
A	LEU135
A	PRO725
A	PRO726
A	THR728
A	5AD1001
A	NJS1002
A	HOH1213
A	HOH1219
A	HOH1228
A	HOH1233
A	HOH1317
A	HIS138
A	HOH1323
A	HOH1343
A	HOH1359
A	HOH1376
A	ALA155
A	VAL222
A	ARG223
A	THR225
A	GLU263

---

site_id	AC2
Number of Residues	5
Details	binding site for residue K A 1003

Chain	Residue
A	THR137
A	TYR141
A	ILE159
A	ASP160
A	HOH1175

---

site_id	AC3
Number of Residues	49
Details	binding site for residues 5AD A 1001 and NJS A 1002

Chain	Residue
A	TYR91
A	THR93
A	MET94
A	ASN97
A	GLN98
A	THR101
A	ARG103
A	TYR105
A	GLY107
A	ALA132
A	ALA155
A	SER180
A	THR182
A	THR211
A	GLN213
A	ARG223
A	ASN252
A	TYR259
A	HIS260
A	ARG299
A	SER301
A	PHE303
A	ARG342
A	THR343
A	HIS344
A	GLN346
A	GLN377
A	SER378
A	ASN382
A	GLU386
A	LEU390
A	PRO391
A	B121000
A	HOH1117
A	HOH1144
A	HOH1145
A	HOH1168
A	HOH1174
A	HOH1210
A	HOH1211
A	HOH1212
A	HOH1273
A	HOH1282
A	HOH1301
A	HOH1321
A	HOH1329
A	HOH1339
A	HOH1388
A	HOH1389

---

Functional Information from PROSITE/UniProt

site_id	PS00213
Number of Residues	12
Details	LIPOCALIN Lipocalin signature. DLE..QVRGRWRNA

Chain	Residue	Details
B	ASP11-ALA22

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site_id	PS00544
Number of Residues	26
Details	METMALONYL_COA_MUTASE Methylmalonyl-CoA mutase signature. RIARNTqlLLlEEshvgRvlDPaGGS

Chain	Residue	Details
B	ARG365-SER390
A	ARG397-SER422

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P11653

Chain	Residue	Details
A	TYR91
A	GLN213
A	VAL222
A	ARG223
A	HIS260
A	ARG299
A	SER301
A	GLY349
A	GLU386
A	ALA389
A	GLY628
A	MET94
A	ASP630
A	ARG631
A	SER674
A	LEU676
A	GLY705
A	THR728
A	THR101
A	ARG103
A	TYR105
A	SER130
A	PHE133
A	ALA155
A	THR211

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: axial binding residue => ECO:0000250|UniProtKB:P11653

Chain	Residue	Details
A	HIS629

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Transition state stabilizer => ECO:0000250|UniProtKB:P11653

Chain	Residue	Details
A	TYR105

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