6OTT
Structure of PurF in complex with ppApp
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0004044 | molecular_function | amidophosphoribosyltransferase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006164 | biological_process | purine nucleotide biosynthetic process |
A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
A | 0006541 | biological_process | glutamine metabolic process |
A | 0009113 | biological_process | purine nucleobase biosynthetic process |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0042802 | molecular_function | identical protein binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0097216 | molecular_function | guanosine tetraphosphate binding |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0004044 | molecular_function | amidophosphoribosyltransferase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006164 | biological_process | purine nucleotide biosynthetic process |
B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
B | 0006541 | biological_process | glutamine metabolic process |
B | 0009113 | biological_process | purine nucleobase biosynthetic process |
B | 0016757 | molecular_function | glycosyltransferase activity |
B | 0042802 | molecular_function | identical protein binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0097216 | molecular_function | guanosine tetraphosphate binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 2 |
Details | binding site for residue MG A 601 |
Chain | Residue |
A | N7Y602 |
A | N7Y602 |
site_id | AC2 |
Number of Residues | 15 |
Details | binding site for residue N7Y A 602 |
Chain | Residue |
A | HIS59 |
A | ARG62 |
A | ARG62 |
A | ALA82 |
A | SER83 |
A | GLU84 |
A | MG601 |
A | MG601 |
A | ARG45 |
A | ARG45 |
A | LYS46 |
A | ALA47 |
A | ASN48 |
A | ARG58 |
A | HIS59 |
site_id | AC3 |
Number of Residues | 2 |
Details | binding site for residue MG B 601 |
Chain | Residue |
B | N7Y602 |
B | N7Y602 |
site_id | AC4 |
Number of Residues | 15 |
Details | binding site for residue N7Y B 602 |
Chain | Residue |
B | ARG45 |
B | ARG45 |
B | LYS46 |
B | ALA47 |
B | ASN48 |
B | ARG58 |
B | HIS59 |
B | HIS59 |
B | ARG62 |
B | ARG62 |
B | ALA82 |
B | SER83 |
B | GLU84 |
B | MG601 |
B | MG601 |
Functional Information from PROSITE/UniProt
site_id | PS00103 |
Number of Residues | 13 |
Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLLVDDSIVRGtT |
Chain | Residue | Details |
A | VAL362-THR374 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_01931, ECO:0000269|PubMed:7037784 |
Chain | Residue | Details |
A | CYS1 | |
B | CYS1 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01931 |
Chain | Residue | Details |
A | THR304 | |
A | ASP366 | |
A | ASP367 | |
B | THR304 | |
B | ASP366 | |
B | ASP367 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 214 |
Chain | Residue | Details |
A | CYS1 | covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor |
A | GLY27 | activator, electrostatic stabiliser, hydrogen bond acceptor |
A | ASN101 | electrostatic stabiliser, hydrogen bond donor |
A | GLY102 | electrostatic stabiliser, hydrogen bond donor |
A | TYR258 | electrostatic stabiliser, hydrogen bond donor |
site_id | MCSA2 |
Number of Residues | 5 |
Details | M-CSA 214 |
Chain | Residue | Details |
B | CYS1 | covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor |
B | GLY27 | activator, electrostatic stabiliser, hydrogen bond acceptor |
B | ASN101 | electrostatic stabiliser, hydrogen bond donor |
B | GLY102 | electrostatic stabiliser, hydrogen bond donor |
B | TYR258 | electrostatic stabiliser, hydrogen bond donor |